ACL_RS00130

Uniprot: A9NE88
Description: cardiolipin synthase
EC number: 2.7.8.-
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol. {ECO:0000256|SAAS:SAAS00006159}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. {ECO:0000256|SAAS:SAAS00006089}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): cls
Gene names (synonym):
Mass: 58,928
Subunit structure [CC]:
Gene ontology (GO): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cardiolipin synthase activity [GO:0008808]; cardiolipin biosynthetic process [GO:0032049]
Gene ontology IDs: GO:0005886; GO:0008808; GO:0016021; GO:0032049
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. {ECO:0000256|SAAS:SAAS00538679}.; SIMILARITY: Contains PLD phosphodiesterase domains. {ECO:0000256|SAAS:SAAS00345906}.
Protein families: Phospholipase D family, Cardiolipin synthase subfamily
Coiled coil:
Domain [FT]: DOMAIN 237 264 PLD phosphodiesterase. {ECO:0000259|PROSITE:PS50035}.; DOMAIN 415 442 PLD phosphodiesterase. {ECO:0000259|PROSITE:PS50035}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NE88
MEROPS:
EnsemblBacteria KO: ABX80668
UniPathway: K06131
CDD:
Gene3D:
HAMAP:
InterPro:
PANTHER: IPR022924;IPR027379;IPR025202;IPR001736
PIRSF:
PRINTS:
PROSITE:
Pfam: PS50035
ProDom: PF13091;PF13396
SMART:
SUPFAM: SM00155
TIGRFAMs:

29332-30841(+)

>nucleotide sequence
ATGAGAAGGTTTATAAATTTACTAACGAATAGACTTACAATCATTGGACTAATTTTGTTA
CTTCAAATTGGTATTTTATGGTGGTTTGTCTATGAGTTTGCAGCAACCTGGTATTACCTT
CATCTTGTATCTATGATACTTGGTGTGATATTAAGTTTATATATTATTACAACCGATGAA
AATCCGATGTTTAAATTGATGTGGGTGGTATTTATGATTGTGCTACCTGTGTTTGGTGTA
CTCTTTTACTTATACGCCAAAACAGAAAGACTATCTATCTCTTCTTCATCAACCATGAGG
CGGATGCAAAAGGTAAGAGAAAATGAGATGCGAAAAATTAAATCCGTTTTTGACCCTAAG
TACTTAAAACAACAAAAATACCTAACCAATTTAAATTTCCCATCTTTTAAAAACACATCT
TCCATTTTTTTAGGTAGTGGTGAAGAAAAACAAACTGAACTTTTAAGAGAACTTAAAAAA
GCAAAACACTTCATCTTCATGGAATACTTTATTATCACGATTTCTAAGATGTGGGATGAA
ATATTACAGGTTCTTATAGAAAAACAAAAACAAGGTGTGGAAATCAGAATCATGTATGAT
GATTTTGGTTCTGCAACCAAACTTCCATTTTATTATCATAAAAAGTTAACTAAAATGGGA
ATTAAAGTTGTTCGTTTTAACCCGATGAAACTACACGTGAACTTTGCTATGAATTTTAGA
GATCATAGAAAAATTGTAGTTATAGATAATAGAGTAGCCTTTACTGGTGGATTTAATATA
GGAGATGAATATACAAATAAGAAAAAAGTATTTGGTCACTGGAATGATGCTGGTATCATG
ATTGAAGGTGAAGCTGTTTGGAGTATGACAATGCTCTTTTTAGAAAACTGGTCGTTTTCT
AAAAAAGATGATACAACTGATTTTTCAAAATATAACATCAAATATCCACCAATTATAAAT
GATGCAATCTATATTCCGTTTGGAGATATCCCGGTAGATAATAATCTAACAGCTAAAAAT
ATATATCTACACTTAATTAATGATGCACAGCAGACAATTTATATTACTGCACCGTACTTA
ATTTTAGATAATGAAATCGCAACCGCACTTAAACTAGCCGCTCAAAGTGGTGTCGATGTA
CACATCATTATGCCAAGTATACCGGATAAGAGATTTGTATATATGGTGTCAAAATCATAT
GCGGAAGAACTTGTTCATAGCGGAGTTAAAATTTATAGATATAAACCAGGGTTTATCCAC
TCTAAGATGATTATTTGTGATAAAGAAGCAGCGATGATTGGATCAAGTAATTTAGACTTT
AGAAGCTTATACATGCACTTAGAAAACAACTTATGGTTGAATGATATAAAAACTATTTCT
AATATGGTTAATTATTATGAATACACACTCAAAGAAAGTGAACGTATTACAATCAAAGAC
TTCACTAAGAGAAATATTATCTATAGAGTAGTACAGGCAGTATTAAAGGGTTTCTCGCCA
TTATTATAA

>protein sequence
MRRFINLLTNRLTIIGLILLLQIGILWWFVYEFAATWYYLHLVSMILGVILSLYIITTDE
NPMFKLMWVVFMIVLPVFGVLFYLYAKTERLSISSSSTMRRMQKVRENEMRKIKSVFDPK
YLKQQKYLTNLNFPSFKNTSSIFLGSGEEKQTELLRELKKAKHFIFMEYFIITISKMWDE
ILQVLIEKQKQGVEIRIMYDDFGSATKLPFYYHKKLTKMGIKVVRFNPMKLHVNFAMNFR
DHRKIVVIDNRVAFTGGFNIGDEYTNKKKVFGHWNDAGIMIEGEAVWSMTMLFLENWSFS
KKDDTTDFSKYNIKYPPIINDAIYIPFGDIPVDNNLTAKNIYLHLINDAQQTIYITAPYL
ILDNEIATALKLAAQSGVDVHIIMPSIPDKRFVYMVSKSYAEELVHSGVKIYRYKPGFIH
SKMIICDKEAAMIGSSNLDFRSLYMHLENNLWLNDIKTISNMVNYYEYTLKESERITIKD
FTKRNIIYRVVQAVLKGFSPLL