ACL_RS00295

Uniprot: A9NEC0
Description: thymidine kinase
EC number: 2.7.1.21
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-phosphate. {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU000544}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site: ACT_SITE 90 90 Proton acceptor. {ECO:0000256|HAMAP-Rule:MF_00124}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 15 22 ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.; NP_BIND 89 92 ATP. {ECO:0000256|HAMAP-Rule:MF_00124}.
Site:
Gene names (primary): tdk
Gene names (synonym):
Mass: 22,162
Subunit structure [CC]: SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00124}.
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; thymidine kinase activity [GO:0004797]; DNA biosynthetic process [GO:0071897]
Gene ontology IDs: GO:0004797; GO:0005524; GO:0005737; GO:0071897
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the thymidine kinase family. {ECO:0000256|HAMAP-Rule:MF_00124, ECO:0000256|RuleBase:RU004165}.
Protein families: Thymidine kinase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEC0
MEROPS:
EnsemblBacteria KO: ABX80700
UniPathway: K00857
CDD:
Gene3D:
HAMAP:
InterPro: MF_00124
PANTHER: IPR027417;IPR001267
PIRSF: PTHR11441
PRINTS: PIRSF035805
PROSITE:
Pfam:
ProDom: PF00265
SMART:
SUPFAM:
TIGRFAMs: SSF52540

66333-66927(+)

>nucleotide sequence
ATGTATCATACATACCGTAATGGTTTCATTGAAGTAGTTTGCGGACCGATGTTTGCAGGT
AAAACTGAAGAACTTATAAGACGTGCAAAACGACTTAAATATGCTAAGCAAAACTATTTA
GTGTTTAAACCAGTCATTGATAATAGATATAGCAGTAAAGCAGAGATTGTATCGCACAGT
TTATTAACGGAAAATGCCATATTAATAGAAAAGTCTAAAGACATTCTTGAACATATGAAT
GATTCTATTGAAGCTGTAATCATTGATGAAGCACAATTCTTTGATCAAGATATTGTTGAA
ATTGCTGATAGACTCGCAGACAGTGGTGTGCGTGTAATTATCGGTGGTTTAGATAGAGAT
TTTAAGGGGGAACCCTTTGGTCCAATGCCACAACTTTTAGCGATTGCAGAGTTTGTTGTA
AAACTCACCGCAATATGTCCTAAAACTGGTACACCAGCAACGCGTACACAACGCATCATT
AATGGTAAGCCAGCACGTATGGATGATCCACTGATTGTTGTAGGCGCATCTGACTCTTAT
GAGCCAAGATCTAGACATGCCCACGAAGTACCAGGAAAATATGATAAAAAATAG

>protein sequence
MYHTYRNGFIEVVCGPMFAGKTEELIRRAKRLKYAKQNYLVFKPVIDNRYSSKAEIVSHS
LLTENAILIEKSKDILEHMNDSIEAVIIDEAQFFDQDIVEIADRLADSGVRVIIGGLDRD
FKGEPFGPMPQLLAIAEFVVKLTAICPKTGTPATRTQRIINGKPARMDDPLIVVGASDSY
EPRSRHAHEVPGKYDKK