ACL_RS00455

Uniprot: A9NED8
Description: 50S ribosomal protein L22
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). {ECO:0000255|HAMAP-Rule:MF_01331}.; FUNCTION: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01331}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rplV
Gene names (synonym):
Mass: 12,317
Subunit structure [CC]: SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_01331}.
Gene ontology (GO): large ribosomal subunit [GO:0015934]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]
Gene ontology IDs: GO:0003735; GO:0006412; GO:0015934; GO:0019843
Chain: CHAIN 1 111 50S ribosomal protein L22. /FTId=PRO_1000086544.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ribosomal protein L22P family. {ECO:0000255|HAMAP-Rule:MF_01331}.
Protein families: Ribosomal protein L22P family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NED8
MEROPS:
EnsemblBacteria KO: ABX80718
UniPathway: K02890
CDD:
Gene3D: cd00336
HAMAP: 3.90.470.10
InterPro: MF_01331_B
PANTHER: IPR001063;IPR018260;IPR005727
PIRSF: PTHR13501
PRINTS:
PROSITE:
Pfam: PS00464
ProDom: PF00237
SMART:
SUPFAM:
TIGRFAMs: SSF54843

87001-87337(+)

>nucleotide sequence
ATGGAAGCTAAAGCAATTGGAAAAACCATTAGAATCGCTCCTAGGAAAGTACGTCTTGTC
GTCGATTTAATTCGTGGTAAGAATGTTAAGGAAGCACAAGCTATTCTAATGTTTACACCT
CGTGGTGCATCACCAGTTATTGCTAAAGTCTTAGACTCAGCAATCGCGAATGCAACACAC
AACTTAAATTTAAACCCAGAAAACTTATTTGTTAAAGAAGTATGGGCTAACGAATCAATT
ACTATGAAAAGAATGTTACCACGCGCTAAAGGTAGTGGGCATTTAATCAGAAAACGTACA
TCACACATTACAGTGGTTGTCGCAGAAAGGGAGTAA

>protein sequence
MEAKAIGKTIRIAPRKVRLVVDLIRGKNVKEAQAILMFTPRGASPVIAKVLDSAIANATH
NLNLNPENLFVKEVWANESITMKRMLPRAKGSGHLIRKRTSHITVVVAERE