ACL_RS00630

Uniprot: A9NEH3
Description: thymidylate kinase
EC number: 2.7.4.9
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP. {ECO:0000255|HAMAP-Rule:MF_00165}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. {ECO:0000255|HAMAP-Rule:MF_00165}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 7 14 ATP. {ECO:0000255|HAMAP-Rule:MF_00165}.
Site:
Gene names (primary): tmk
Gene names (synonym):
Mass: 23,148
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; thymidylate kinase activity [GO:0004798]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]
Gene ontology IDs: GO:0004798; GO:0005524; GO:0006233; GO:0006235
Chain: CHAIN 1 201 Thymidylate kinase. /FTId=PRO_1000076956.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000255|HAMAP-Rule:MF_00165}.
Protein families: Thymidylate kinase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEH3
MEROPS:
EnsemblBacteria KO: ABX80753
UniPathway: K00943
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_00165
PANTHER: IPR027417;IPR018095;IPR018094
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01331
ProDom:
SMART:
SUPFAM:
TIGRFAMs: SSF52540

108886-109492(+)

>nucleotide sequence
ATGTTTATTACATTTGAAGGCGGAGAAGGTAGCGGTAAAACGACCTTAATCGAAAAACTA
AAACACACATTACTAGAGAAAAAATACGATGTACTAACCACGCGTGAACCTGGTGGATCT
AAGGTTGCTGAAAAAATTCGTTCTGTATTACTGGATAATAAAAACACAGAAATCACTGCA
CATACAGAAGCTCTTTTATTTGCAGCAAGTAGAGCACAACATTTAGATGAAGTCATCATT
CCTAATTTAGATAAAGTCATACTTTGTGACCGATATATCGATTCATCCTATGCGTATCAA
GCGTTTGGTAGAAACCTAGGTATGGAGTTTGTTCAAAGTATTAATAGTTATGCATTAAAA
TACTTACCTGACTTAACATTTTATATCGACTTAGATCCTAAAACAGGTATTGATAGAGTA
AAGAAAAACAGATTACATAAAACAGATAGATTAGACATGGAAGTTCAAACATTTCATCAA
AAGGTACGTGAAGGTTATATTCGCATTTCAGAAATGTTTAAAGAACGTATCGTCGTGATT
GATGGTAATCAATCGATTGATGCAATCTATCAAATTATAATGGATAACATATTAAAACGC
CTATGA

>protein sequence
MFITFEGGEGSGKTTLIEKLKHTLLEKKYDVLTTREPGGSKVAEKIRSVLLDNKNTEITA
HTEALLFAASRAQHLDEVIIPNLDKVILCDRYIDSSYAYQAFGRNLGMEFVQSINSYALK
YLPDLTFYIDLDPKTGIDRVKKNRLHKTDRLDMEVQTFHQKVREGYIRISEMFKERIVVI
DGNQSIDAIYQIIMDNILKRLW