ACL_RS00870

Uniprot: A9NEM3
Description: bifunctional acetaldehyde-CoA/alcohol dehydrogenase
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 95,109
Subunit structure [CC]:
Gene ontology (GO): acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; alcohol dehydrogenase (NAD) activity [GO:0004022]; metal ion binding [GO:0046872]; alcohol metabolic process [GO:0006066]; carbon utilization [GO:0015976]
Gene ontology IDs: GO:0004022; GO:0006066; GO:0008774; GO:0015976; GO:0046872
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. {ECO:0000256|PIRNR:PIRNR000111}.; SIMILARITY: In the N-terminal section; belongs to the aldehyde dehydrogenase family. {ECO:0000256|PIRNR:PIRNR000111}.
Protein families: Iron-containing alcohol dehydrogenase family; Aldehyde dehydrogenase family
Coiled coil:
Domain [FT]: DOMAIN 10 270 Aldedh. {ECO:0000259|Pfam:PF00171}.; DOMAIN 456 847 Fe-ADH. {ECO:0000259|Pfam:PF00465}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEM3
MEROPS:
EnsemblBacteria KO: ABX80803
UniPathway: K04072
CDD:
Gene3D:
HAMAP: 3.40.309.10;3.40.605.10
InterPro:
PANTHER: IPR001670;IPR018211;IPR016161;IPR016163;IPR016162;IPR015590;IPR012079
PIRSF:
PRINTS: PIRSF000111
PROSITE:
Pfam: PS00913
ProDom: PF00171;PF00465
SMART:
SUPFAM:
TIGRFAMs: SSF53720

165155-167744(+)

>nucleotide sequence
ATGGAAAAAGACACACTTATCTTAAACGAGGTAGATCTTTTAGTCACGTCTGCTTTAGAA
GCACTTGACGAATACATGGAGTTTACCCAAGAGAAGATTGATGAGATTGTAGCCAAAGTT
TCTGTTGAAGCAATTGATGCACATGGCCGTTTAGCCAAGCTTGCTGTAGAGGAAACTAAA
CGAGGGGTATTTGAAGATAAAGCAACCAAGAATTTATTTTCAGTAGAATATGTCATCAAT
CATATGAGACACCTAAAAACTGTAGGGATTATCTCGGAAAATACAGTAACGGGTATTACA
GAGGTAGCTGATCCTGTTGGGGTAATTTGCGCTATTACACCAGTAACGAATCCAACATCG
ACGACAATATTTAAGTCATTGATTGCACTTAAAACTAGAAATCCAATCGTCTTTGCGTTT
CATCCAAATGCGCAAAATTCATCAAAGGAAGCGGCTAGAATTATTAAAGAAGCAGCGATT
AAATCAGGTGCTCCAAAAAATTGTATTTCATGGATTGAACATCCAAGTTTAGATAATACA
AATAAACTTATGAACCACCCGGGGATTGCAACTATTTTAGCAACTGGTGGTAATGCAATG
GTTAAGGCAGCTTACTCATGTGGTAAACCAGCTCTTGGTGTCGGTGCAGGTAACGTACCA
GCATACATTGAAAAAACTGCAAACATTAAAACCGCAATCAATGATATTGTTATGTCTAAG
TCATTTGATAATGGTATGGTATGTGCATCTGAACAAGCAGCTATTATTGATAAAGAAATC
TATAAAGAAGCTTTGGCGGAATTTAAAAAGTTACATACTTTTTTATGTAACAAAGAACAA
AAACAAATGCTGGAAACATTTATGTTCCCAGATGGTGTCAAGCTTAATCCTTATGTTGTA
GGTAAGAGTGCACATCACATTGCAGAACTTGCAGGTTTCGAAGTTCCTTTAAATACCAAC
ATTTTACTAGTAGAATGTAAAAGTGTTGGTAAAGAAGAACCACTTACAAGAGAAAAACTC
TCGCCAGTATTAGCAATTCTTAAATCAAATGATGAAGTACATGGTGTAGCACTTGCAAAA
AGTATGGTAGAACTTGATGGTTTAGGACACTCTGCAGTGATTCACACACAAAATGATGAA
CTTAAAAAAACCTTTGGTTTAGCACTTAAAGCGATACGTATTATAGTGAATTCACCAGCG
ACTTTTGGTGGCATAGGTAATGTATATAACAGGTTTATACCATCACTTACCTTAGGGTGT
GGTTCTTATGGTAAAAACTCTGTTTCTGATAATGTCAGTGCCATCCACTTACTTAATATC
AAACGTATCGGTGAAAGGAAAAATAATATGCAATGGTTTAAGGTTCCATCTAAAATTTAC
TTTGAAAAAGATTCTATTGAATACTTAAGACAAATGAGAGATGTTAACAAGGTTGTCATC
ATCACAGATAGAGTGATGGTTGACTTAGGTTATGTTAAAAAAGTAACTGATCAACTAAGT
TTAAGACGTAATCATGTTGTATATCAACTATTTACCGATGTTGAAGCTGATCCATCCATT
GAAACAGTTCATAAAGGTTATGAACTGATGAAATCCTTCCAACCAGATACGATTATAGCT
ATTGGTGGTGGTTCACCAATGGATGCTGCAAAAGCTATGTGGTTATTCTATGAAAACCCT
GAAGTAGATTTTAACGACTTAAAACAAAAATTCATGGATATTAGAAAACGTGCATTTAGA
TATCCTGATTTAGGTAGAAAATCTAAATTAGTATGTATTCCAACAACCTCAGGTACTGGT
AGTGAAGTGACTCCGTTTGCAGTTATCACTGATAATAAAGAGTCTAAAAAATATCCATTA
GCAGATTATTCATTAACACCAACTGTAGCTATTATTGACCCTGCACTTACACTTACTCAA
CCAAAATCTGTTACAGCAGATACTGGAATGGACGTGTTAACACATGCAGTAGAAGCTTAC
GTTTCAGTACTTGCTAATGACTATACAGACTCACTTGCAATTCAAGCAGTTAAAATGGTA
TTTAAATACTTAAAACGTGCATTTGATAATGGATTGGACTTTGAAGCAAGAGAAAAGATG
CATAATGCATCTACCATGGCAGGTATGGCATTTGGTAATGCATTCTTGGGTATATCTCAC
TCTATGGCTCATAAAGTAGGTGGAAGATATCATATACCTCATGGTAGAATTAATGCAATC
TTATTACCACATGTCGTTTTATATAATGGTACAGTTCCAGCTAAGTTATCTACTTGGCCA
AAATACACATATTATGTAGCAGATGAAAAATACATGGAACTAGCTAGAGCAATCGGATTA
GATCCTAAATCTAAAGAAGAAGGCGTTAAGATGTTTGCTAAGGCATGTCATGATTTAGCA
GTATCATTAGGTATTAATATGAGTTTTGCTAGTCAAAAAGTAGAAGAAAAAGATTTCTTA
GAACACAGTGAAACTTTAGCTTATCTAGCTTATGAGGATCAATGTTCAACAGCTAACCCT
AGACTACCTTTAGTAGCGGATATGAAGGTGATCCTAGAAAATGCATATTACGGCAAACTA
GATATATAG

>protein sequence
MEKDTLILNEVDLLVTSALEALDEYMEFTQEKIDEIVAKVSVEAIDAHGRLAKLAVEETK
RGVFEDKATKNLFSVEYVINHMRHLKTVGIISENTVTGITEVADPVGVICAITPVTNPTS
TTIFKSLIALKTRNPIVFAFHPNAQNSSKEAARIIKEAAIKSGAPKNCISWIEHPSLDNT
NKLMNHPGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYIEKTANIKTAINDIVMSK
SFDNGMVCASEQAAIIDKEIYKEALAEFKKLHTFLCNKEQKQMLETFMFPDGVKLNPYVV
GKSAHHIAELAGFEVPLNTNILLVECKSVGKEEPLTREKLSPVLAILKSNDEVHGVALAK
SMVELDGLGHSAVIHTQNDELKKTFGLALKAIRIIVNSPATFGGIGNVYNRFIPSLTLGC
GSYGKNSVSDNVSAIHLLNIKRIGERKNNMQWFKVPSKIYFEKDSIEYLRQMRDVNKVVI
ITDRVMVDLGYVKKVTDQLSLRRNHVVYQLFTDVEADPSIETVHKGYELMKSFQPDTIIA
IGGGSPMDAAKAMWLFYENPEVDFNDLKQKFMDIRKRAFRYPDLGRKSKLVCIPTTSGTG
SEVTPFAVITDNKESKKYPLADYSLTPTVAIIDPALTLTQPKSVTADTGMDVLTHAVEAY
VSVLANDYTDSLAIQAVKMVFKYLKRAFDNGLDFEAREKMHNASTMAGMAFGNAFLGISH
SMAHKVGGRYHIPHGRINAILLPHVVLYNGTVPAKLSTWPKYTYYVADEKYMELARAIGL
DPKSKEEGVKMFAKACHDLAVSLGINMSFASQKVEEKDFLEHSETLAYLAYEDQCSTANP
RLPLVADMKVILENAYYGKLDI