ACL_RS01050

Uniprot: A9NEQ9
Description: large-conductance mechanosensitive channel
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. {ECO:0000256|HAMAP-Rule:MF_00115, ECO:0000256|SAAS:SAAS00349878}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): mscL
Gene names (synonym):
Mass: 20,141
Subunit structure [CC]: SUBUNIT: Homopentamer. {ECO:0000256|HAMAP-Rule:MF_00115, ECO:0000256|SAAS:SAAS00023917}.
Gene ontology (GO): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ion channel activity [GO:0005216]
Gene ontology IDs: GO:0005216; GO:0005886; GO:0016021
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the MscL family. {ECO:0000256|HAMAP-Rule:MF_00115, ECO:0000256|SAAS:SAAS00544201}.
Protein families: MscL family
Coiled coil: COILED 127 150 {ECO:0000256|SAM:Coils}.
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEQ9
MEROPS:
EnsemblBacteria KO: ABX80839
UniPathway: K03282
CDD:
Gene3D:
HAMAP:
InterPro: MF_00115
PANTHER: IPR019823;IPR001185
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01327
ProDom: PF01741
SMART:
SUPFAM:
TIGRFAMs: SSF81330

205743-206280(+)

>nucleotide sequence
ATGGGTAAACAAATCAAAATATCCAAGGAACAACGTAAAAAAGGTTTCTTAAATGGATTT
AAGAATTTTATCATGCGTGGAAACGTTATTGATATGGCAGTGGGTGTAATTGTTGGTGGA
GCTTTCGGTAAGATTGTTACAAGTCTTGTCAATGACATTATATTACCTCCAATTGGTGTT
TTATTAGGCGGTGTGGAGTTTAGAGACTTACAAGCACTGATTCATCAAAAACCAGTTTTA
GATGATAATGGTGCACAAGTCGTGATTGATGGTATTGCACAATTTAATAATGTATATATT
CGTTATGGGAATTTAATTCAAATCATTTTAGAATTCTTAATTATTGCATTTTCTATTTAT
CTCGTTTTATATATCTTTATAAAACGTAAGGAACAAGAAGAGAAATTTATTGCTGAAGAA
AAAGCAAGACTAGAAAAATTAGAAGCTGAAAAAAATCCTCCAAAACCAGCACCAAAACCA
GAAGACATTCAATTGCTAATCGAAATTAGGGATTTACTAAAGAAAAATGAAAAGTAA

>protein sequence
MGKQIKISKEQRKKGFLNGFKNFIMRGNVIDMAVGVIVGGAFGKIVTSLVNDIILPPIGV
LLGGVEFRDLQALIHQKPVLDDNGAQVVIDGIAQFNNVYIRYGNLIQIILEFLIIAFSIY
LVLYIFIKRKEQEEKFIAEEKARLEKLEAEKNPPKPAPKPEDIQLLIEIRDLLKKNEK