ACL_RS01215
| Uniprot: A9NEU3
Description: PolC-type DNA polymerase III EC number: 2.7.7.7 Annotation score: 2 out of 5 Miscellaneous [CC]: Protein existence: Inferred from homology Catalytic activity: CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). {ECO:0000256|HAMAP-Rule:MF_00356, ECO:0000256|SAAS:SAAS00057091}. Cofactor: Enzyme regulation: Function [CC]: FUNCTION: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. {ECO:0000256|HAMAP-Rule:MF_00356, ECO:0000256|SAAS:SAAS00229340}. Pathway: Active site: Binding site: Calcium binding: DNA binding: Metal binding: Nucleotide binding: Site: Gene names (primary): polC Gene names (synonym): Mass: 172,514 Subunit structure [CC]: Gene ontology (GO): cytoplasm [GO:0005737]; 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA-dependent DNA replication [GO:0006261] Gene ontology IDs: GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 Chain: Signal peptide: Domain [CC]: Sequence similarities: SIMILARITY: Belongs to the DNA polymerase type-C family. PolC subfamily. {ECO:0000256|HAMAP-Rule:MF_00356, ECO:0000256|SAAS:SAAS00556408}.; SIMILARITY: Contains exonuclease domain. {ECO:0000256|SAAS:SAAS00242420}. Protein families: DNA polymerase type-C family, PolC subfamily Coiled coil: Domain [FT]: DOMAIN 324 391 POLIIIAc. {ECO:0000259|SMART:SM00481}.; DOMAIN 411 597 Exonuclease. {ECO:0000259|SMART:SM00479}. Motif: Region: EMBL: CP000896 ProteinModelPortal: A9NEU3 MEROPS: EnsemblBacteria KO: ABX80873 UniPathway: K03763 CDD: Gene3D: HAMAP: 2.40.50.140;3.30.420.10 InterPro: MF_00356 PANTHER: IPR011708;IPR029460;IPR006054;IPR013520;IPR012340;IPR004013;IPR003141;IPR006308;IPR012337 PIRSF: PRINTS: PROSITE: Pfam: ProDom: PF07733;PF14579;PF02811;PF00929 SMART: SUPFAM: SM00479;SM00481 TIGRFAMs: SSF53098 |
|
|
242424-246939(+) >nucleotide sequence ACTGCATATTTAAATTCAGTTACTGTAAAGGTACGAGAAAAAACCTTAATATTTGATATA ACATTTGATGAATTGATGTTACCAAGTGAAATGAGTTTATTTACCAATCAACTACAAACA TTGTTTTTAAAAAAGGATGTTGTTTCACGTGTAGACTACCAGTTCACATTTAAACAAGCA GATTTATCAGCACACTATAAAACTTATTATGAAGCTTTAATTCATAAAGCTTCTGAAATT TTTCAACCCGTACTTATTTTTAAAAATTACACAGTTGAATATGAAAATAACATCTATACA ATTTTAATTGAAAAAGATAGTAGAGGGTTAAAAAAATATCTACCAGAATTAAAGAAATAC TTTAAAAAACATGGTTTAGATGTTGATTTTACACTGAAGGTTAATGAGGATTTAATCCCG GTTGCTGAACAAGTAAGACAAACCATTGAATCTCAAAAAGAGAGTATGGAGCGTCTAGTT AAAACAGCTGATGCTGTCATTTTAGATAAAAAGACAACATTTAATAGAAAATCTAGTCCA TCTGCTGTAGCTATTAGTGAAATACCTAAGAGTGCCTATGAACTTGATAAATACCAAAAT GAAAAAGGCGATGTAAACTTTTTAATTGAAGGTGAAGTGTTTAAAACTGAGGTTAGAGAA CTTAAGAATACAAACCTTTTAACGATGTCTATTTTTGACAAGGATGATGCAATTACAGTC AAAAGATTTGTAAGAGCACCTAAAGATGTTGCTTTAGCCAAAGAAGTTAAAGTTGGAGAT ATTATCCAAGTATCTGGTCGTGCAGAATATGACACTTTCCAAAAAGAAGTCACAATCATG GCAACAGCCTTTTATCAAATCGAGCGACCTAAAAAGTTTGAACGTATCGATAAAGCAAAA GAAAAGCGTGTCGAGTTTCATATCCATACCAAAGCATCACCTATGGATGCAGTCACCTCA ATTACCGATTATGTAGAAACCCTAGAAAGTTGGGGACATAAAGCTTTTGCGATTACTGAT AGAAATGGTTTATATGCTTATCCTGAACTACATAAAGCAATTAAAGGTAAAAAGATTAAA CCAATATATGGTGTTCAACTAGATTATGTTGACGATGAAGCTTTTTGGGTTGCTAAAGAC TATCATGAAGATATTTTACTTAAAGAAGCAGTCTACACGGTTTTTGATATTGAAACCACA GGTTTTTCATTTACAAGAGATAAAATCATAGAAATTGCTGCATATAAAGTCAGAGGTGGA TTTATTGCAGAACGTTTTGAAGTCTTAATTAATCCTGAAGAGCAGTTAAGTGAAACTACA AAACGTATTACAAATATTACAGATGAAATGGTTGAAAACGAAAAAACCATTGAAGAAGTA TTACCGACCTTCTTAGAATTTATTAAGGGCACTGTATTAGTTGCTCATAATGCATCCTTT GATATCGGCTTTATCTATGAAAAATCTAGATTACTTGGTCTACAACATGAACCGTTTGCA GTTATAGATACTTTAAATATTGCAAGATACTTTTATAACAACACGAATAAAGAAAAGAAC CATGCAAGATTCTATGTCAATGATGCTGGCAATATTCCCGATCTAAAAAGATTTAACTTA AAAGCTTTAACGAAGTTCTTTAAAGTCAATCTAGAAGCACATCACCGTGCTATCTATGAT GCCTATGCAACTGCAGAAGTGTTTTTAAACATGCTACAAGATTTCTATAAAGAAGAAATA TATAGTTATTTTGAATTACAAGCATCCCTTGATATGAATGAAGTATGGCGTCATCCAATT CCCAAATACGCCACTGTTCTAGCTCAAACTCAAGAAGGTTATAAAAACTTATTCAAATTG GTATCTGATGCCTTAACTACACACTTTGACGGTGGCCCAAGATTATTAAAATCTGCCTTT CTAAAATATAGAGAAGGTTTATTAATTGGTAGTGGAACCGAACATAGTGAAGTATTTGAA GCTGCACTTAATTTAAATGATGAACAATTAAAAGAAGCAATCTCATTTTATGACTATATT GAGGTACAACCACTTAATGCATACCTGCATCTAGAAAAAGAAATCGGTGCACTCGGTAGA GAAGTCATTCAAGCAGCAATTAAAAAGATTATTACCTATGCAAAAGAGCAAAATAAAATA GTGATCGCATCTTCTAATGCCCACTATTTAAATCCAGAGGATAAAAAATATAGAGAAATA TACATTCAAACAAAATCTGTTGGTGGTGGACTACACCCACTTGCAAACTATGAAACTTCA CCAGACCAACATCTTCTAACAACCACTGAAATGTTGGATGCATTCTCATTTTTAGATCAA CAAACAGCTTATGAGATAGTAGTTACGAATACGAACAAGTTAAGTGATATGTTTGAGAAT GTACGAGCTTTTCCTAAAGAACTGTACTCTATTAAAGATCACGCATTTAAAGATACATTA GGTATTCCTTCAATTAAAGAACATGTTGAAGAAATGGTTATGAATGAAGCTAAAAGATTA TATGGTGATCCAATACATCCATATGTATTAGGTAGAGTTCAAAGAGAATTAACCAATATT ATTGATAACCAATTTGCACCCATTTACTTTATTTCTCATTTATTAGTTAAAAAATCATTA GATGATGGCTACTTAGTAGGTTCTAGAGGATCTGTTGGATCTTCACTTGTAGCAACCTTA ATGAATATTACAGAAGTCAACCCTTTAAGACCGCATTTCCGTTGTAAGAAGGGTGAATAT GCAGTTTTTAAATTAACCGATGAAGAAATCTATGAACAAGGTGTAGATGCTAGAGATGAA CCGTTCATCGAAGTATTAAAACATGTCAAATCAGGTTATGACCTACCAGATATGAAGTGT CCTATTTGTGGGGAACTCATGCATAAAGATGGTCATGATATTCCGTTTGAAACCTTCTTA GGTTTTGATGGGGATAAAATTCCTGATATCGACTTAAACTTTAGTGGAGATTATCAATCT AAAGCACATGATTATGTTAGAGAACTATTAGGTGAAGAATATACCTTTAGAGCAGGAACC ATTCAAACAGTTGCTGAACGTAACGCATTTGGTTATGTTAAAGGTTATTTAGAATACCTA GGTAAAGATGCAAGAAGTGCATATATTGAGCGTCTAGCTAAAGGTATTGAAGGTGTGAAA CGTTCAACTGGTCAGCACCCTGGTGGGATTGTTGTTGTACCAAAGGATAAATCTATTTAT GATGTCACACCAATTCAATATCCAGCAGATGATGTCAATAGTGCATGGAAGACAACACAT TTTGATTACCATGCCTTTGAAGATAACTTACTAAAACTAGATATTCTAGGTCACGATGAT CCAACCATGATCAAATTCTTAATGGACTATGTTAAAGAGCATCCAGAGGATTTCCCTTTT GATAATGCACAAGACATTCCACTGGATGATCCAAATGTCTACCGTTTATTCCAAGATACC TCGGTGATTGGATTAAAAGATAAAGATGATGTTTATGGTGATATTGCAAGTTATGCAATT CCAGAATTTGGTACACCATTTACAAGACAAATGTTACAACAAACAAGACCTTCAACATTT GCAGGTTTGGTTAAAATATCTGGTCTATCACACGGTACAGACGTGTGGTTAAAAAACTCA CAAGAACTTGTATTAGGTTCAACCCAATTTGGGAAAATTTCATTCGATGACATTATTGGT TGTCGAGACGATATTATGGTGGAGTTATCTGACCGTGGTATGAAAGAAGCTAAAGCATTT GAAATTATGGAGTTTGTCAGAAAGGGTAAACCTTCATCAAACCCTAAAAAATGGGCTGAA TATGAAAATGAGATGAAAGCAAGTAAGATACCTGATTGGTATATATGGAGTGCATCTCAA ATTAAGTATATGTTCCCTAAAGCGCATGCGACTGCATATGTGATTATGGCAATGCGTATT GCATGGTTTAAGGTCTATAGTCCATTGTTATTCTATTCAAGTTTCTTTAGTAAACGTGCT GTGCAATTTGAGCATGACATTATGGTTGCAGGTACAAATGCAATTAGAAACAGAATTAAT ACTTTAAGAAATGACAATAACATTACTGCAAAAGACCAGGATGTGATTGTGACACTTTTA GTCGCACTTGAAATGACTAAGCGTGGATTTAAGTTTTTACCGGTCAACATTAAAAAATCA CACGCTAAAGAGTTTGTGATGGAAAAAAATGGATTACGTATGCCTTTTTCAAGTATTGAT GGCCTTGGGTTACAAGCTGCAATCAATATTGTTGAAAATAGAGAAGAAAAACCTTATAAT TCAAAAGAAGATGCAAGAGTACGTGGAAAGTTAAACAAGACAGTATTTGAAAGATTAGAT TTAGCTGGCGCATTTGATGACTTAGCAGATGTAAGTAGTGAACTTGATCATGGGTTATTT GCTCATAAATACTAA >protein sequence LFLKKDVVSRVDYQFTFKQADLSAHYKTYYEALIHKASEIFQPVLIFKNYTVEYENNIYT ILIEKDSRGLKKYLPELKKYFKKHGLDVDFTLKVNEDLIPVAEQVRQTIESQKESMERLV KTADAVILDKKTTFNRKSSPSAVAISEIPKSAYELDKYQNEKGDVNFLIEGEVFKTEVRE LKNTNLLTMSIFDKDDAITVKRFVRAPKDVALAKEVKVGDIIQVSGRAEYDTFQKEVTIM ATAFYQIERPKKFERIDKAKEKRVEFHIHTKASPMDAVTSITDYVETLESWGHKAFAITD RNGLYAYPELHKAIKGKKIKPIYGVQLDYVDDEAFWVAKDYHEDILLKEAVYTVFDIETT GFSFTRDKIIEIAAYKVRGGFIAERFEVLINPEEQLSETTKRITNITDEMVENEKTIEEV LPTFLEFIKGTVLVAHNASFDIGFIYEKSRLLGLQHEPFAVIDTLNIARYFYNNTNKEKN HARFYVNDAGNIPDLKRFNLKALTKFFKVNLEAHHRAIYDAYATAEVFLNMLQDFYKEEI YSYFELQASLDMNEVWRHPIPKYATVLAQTQEGYKNLFKLVSDALTTHFDGGPRLLKSAF LKYREGLLIGSGTEHSEVFEAALNLNDEQLKEAISFYDYIEVQPLNAYLHLEKEIGALGR EVIQAAIKKIITYAKEQNKIVIASSNAHYLNPEDKKYREIYIQTKSVGGGLHPLANYETS PDQHLLTTTEMLDAFSFLDQQTAYEIVVTNTNKLSDMFENVRAFPKELYSIKDHAFKDTL GIPSIKEHVEEMVMNEAKRLYGDPIHPYVLGRVQRELTNIIDNQFAPIYFISHLLVKKSL DDGYLVGSRGSVGSSLVATLMNITEVNPLRPHFRCKKGEYAVFKLTDEEIYEQGVDARDE PFIEVLKHVKSGYDLPDMKCPICGELMHKDGHDIPFETFLGFDGDKIPDIDLNFSGDYQS KAHDYVRELLGEEYTFRAGTIQTVAERNAFGYVKGYLEYLGKDARSAYIERLAKGIEGVK RSTGQHPGGIVVVPKDKSIYDVTPIQYPADDVNSAWKTTHFDYHAFEDNLLKLDILGHDD PTMIKFLMDYVKEHPEDFPFDNAQDIPLDDPNVYRLFQDTSVIGLKDKDDVYGDIASYAI PEFGTPFTRQMLQQTRPSTFAGLVKISGLSHGTDVWLKNSQELVLGSTQFGKISFDDIIG CRDDIMVELSDRGMKEAKAFEIMEFVRKGKPSSNPKKWAEYENEMKASKIPDWYIWSASQ IKYMFPKAHATAYVIMAMRIAWFKVYSPLLFYSSFFSKRAVQFEHDIMVAGTNAIRNRIN TLRNDNNITAKDQDVIVTLLVALEMTKRGFKFLPVNIKKSHAKEFVMEKNGLRMPFSSID GLGLQAAINIVENREEKPYNSKEDARVRGKLNKTVFERLDLAGAFDDLADVSSELDHGLF AHKY |
© Fisunov Lab of Proteomics, 2016.