ACL_RS01295

Uniprot: A9NEV8
Description: anhydro-N-acetylmuramic acid kinase
EC number: 2.7.1.170
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + 1,6-anhydro-N-acetyl-beta-muramate + H(2)O = ADP + N-acetylmuramate 6-phosphate. {ECO:0000256|HAMAP-Rule:MF_01270, ECO:0000256|SAAS:SAAS00085899}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. {ECO:0000256|HAMAP-Rule:MF_01270, ECO:0000256|SAAS:SAAS00085896}.
Pathway: PATHWAY: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. {ECO:0000256|HAMAP-Rule:MF_01270, ECO:0000256|SAAS:SAAS00085891}.; PATHWAY: Cell wall biogenesis; peptidoglycan recycling. {ECO:0000256|HAMAP-Rule:MF_01270, ECO:0000256|SAAS:SAAS00085898}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 13 20 ATP. {ECO:0000256|HAMAP-Rule:MF_01270}.
Site:
Gene names (primary): anmK
Gene names (synonym):
Mass: 41,922
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar metabolic process [GO:0006040]; carbohydrate metabolic process [GO:0005975]; peptidoglycan turnover [GO:0009254]
Gene ontology IDs: GO:0005524; GO:0005975; GO:0006040; GO:0009254; GO:0016301; GO:0016773; GO:0097175
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the anhydro-N-acetylmuramic acid kinase family. {ECO:0000256|HAMAP-Rule:MF_01270, ECO:0000256|SAAS:SAAS00570385}.
Protein families: Anhydro-N-acetylmuramic acid kinase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEV8
MEROPS:
EnsemblBacteria KO: ABX80888
UniPathway: K09001
CDD:
Gene3D:
HAMAP:
InterPro: MF_01270
PANTHER: IPR005338
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF03702
SMART:
SUPFAM:
TIGRFAMs:

262365-263484(+)

>nucleotide sequence
ATGAGTGGTACATCATTAGATGGTATAGATGTTGCAATAGCAACAATTTCAGGTACTGGT
CTTAATACAAAAATTGAACTCATCGTAGCAGAAACTTTTCCTTATCCCAAGGATATCTTA
GAGAAAGTGAAACTGGCTATTGATAATGAACTAAGGGTAAGAGACGTATCGAGTCTCAAT
TTTGAACTTGGTAGACTTTATGCAGACTGTGTGATTAAGTTATGTAAAGACAACAAGCTA
AGTCCTTCAAGTTTGAGTTTTATCGCATCGCATGGACAAACTGTCTACCACCAAGGTGCT
ACACAAGATGGAAGTAATCCAAACACACTTCAATTAGGTAGTGGATCTGTGATTGCAGGG
TTAACCCAAACAACTGTCGTCTCTGACTTTAGAGTAGCAGATATGATTGCAGGTGGCCAA
GGGGCACCCCTTGTTCCTTTTGTAGATTATATTTTACTATCAAATAAAGATAAAACACGT
ATCATTCAAAATATTGGAGGTATCTCTAATATTACAGTATTACCAAAGACTCAACATGAA
AAAGATGTATACGCCTTTGATACAGGTCCAGGTAATATGATGATTAATTATGCGATGGAA
TATTTCTTTAATAAACCTTATGATGCATTCGGCGAGACTGCTAAAAAAGGAAACCTTATT
AAGGCATTATATGATGAAATACTTCAACACCCATTCTTAAAACTACAACCACCTAAATCA
TGTGGTAGAGAAGAATTTGGTGTGAGTTTCACAAAAGAGTTAATAAAAAGATATCATAAT
CATACAAGAGAAGACATCTTACATACACTCACCGTAGCGACAGCAGACACGATGGTTAAA
GCTATAGAACAATTTGTTTTAAATAAACACGAAGTAGATGAACTGATTATTTCCGGTGGT
GGTGTTCATAACACCTTTATGATGGATCAATTAAAGAAAAAACTACACCCAATACACGTC
TTATCCACAGATGATATTGGTTTGTCAAGTGATTTTAAAGAGGCTCTAGCATTTATTGTT
TTAGCCAATCAAACAATGTATCAAGAACCGTCCAATCTACCTACAGCAACTGGTGCAAAA
AAAGCTGTCGTACTTGGTAATGTTTCTTACTACAGATAA

>protein sequence
MSGTSLDGIDVAIATISGTGLNTKIELIVAETFPYPKDILEKVKLAIDNELRVRDVSSLN
FELGRLYADCVIKLCKDNKLSPSSLSFIASHGQTVYHQGATQDGSNPNTLQLGSGSVIAG
LTQTTVVSDFRVADMIAGGQGAPLVPFVDYILLSNKDKTRIIQNIGGISNITVLPKTQHE
KDVYAFDTGPGNMMINYAMEYFFNKPYDAFGETAKKGNLIKALYDEILQHPFLKLQPPKS
CGREEFGVSFTKELIKRYHNHTREDILHTLTVATADTMVKAIEQFVLNKHEVDELIISGG
GVHNTFMMDQLKKKLHPIHVLSTDDIGLSSDFKEALAFIVLANQTMYQEPSNLPTATGAK
KAVVLGNVSYYR