ACL_RS01520

Uniprot: A9NEZ6
Description: guanylate kinase
EC number: 2.7.4.8
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + GMP = ADP + GDP. {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00036666}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Essential for recycling GMP and indirectly, cGMP. {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00036649}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 14 21 ATP. {ECO:0000256|HAMAP-Rule:MF_00328}.
Site:
Gene names (primary): gmk
Gene names (synonym):
Mass: 23,689
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]
Gene ontology IDs: GO:0004385; GO:0005524; GO:0005737
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000256|HAMAP-Rule:MF_00328, ECO:0000256|SAAS:SAAS00548802}.; SIMILARITY: Contains 1 guanylate kinase-like domain. {ECO:0000256|HAMAP-Rule:MF_00328}.
Protein families: Guanylate kinase family
Coiled coil:
Domain [FT]: DOMAIN 7 186 Guanylate kinase-like. {ECO:0000259|PROSITE:PS50052}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEZ6
MEROPS:
EnsemblBacteria KO: ABX80926
UniPathway: K00942
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_00328
PANTHER: IPR008145;IPR008144;IPR017665;IPR020590;IPR027417
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00856;PS50052
ProDom: PF00625
SMART:
SUPFAM: SM00072
TIGRFAMs: SSF52540

313991-314609(+)

>nucleotide sequence
ATGAAACTAAATGATCGTGGATTACTCATCGTCATATCCGGACCATCTGGAGTTGGAAAA
GGTACAGTGCGTAAAGCGCTTTTTGACATGAAGAACCATAACCTAGAATATTCTGTATCA
GTTACAACAAGAGCACCTAGAGTCGGCGAAGTTGATGGCAAAGACTATTATTTTGTAAAT
CGTGCAGCCTTCGAAGAAATGATTCGCCAAGACAGATTTTTAGAGTATGCAGAGTTTGTG
GGTAGCTATTATGGCACACCAAAAGACAAAGTTGAAGAAATGCTTGATAAAGGTAAAGAA
GTTGTATTAGAAATTGAAGTGGATGGTGCACTTCAAGTACGTGAACGTATGAAAGATGCT
GTCTTTATATTTTTAGTGCCACCAAGCAAAAAAGCCTTATATGAGCGTTTAAGCAGACGT
GGAACGGATACACCTGAAATTGTAAATAAGAGATTTCAAAAAGCTGAAAGTGAATTTAAA
TTAGCATATAAATATGATTATATCGTAGTAAATGATGATGTAAATAATGCTGCAGATCGT
ATTATGGCGATCATTCGTGCAGAACATGCACGTACTCAAAGAACTATTCAAAAATATCAA
CAGTTAATGGAGGAATAA

>protein sequence
MKLNDRGLLIVISGPSGVGKGTVRKALFDMKNHNLEYSVSVTTRAPRVGEVDGKDYYFVN
RAAFEEMIRQDRFLEYAEFVGSYYGTPKDKVEEMLDKGKEVVLEIEVDGALQVRERMKDA
VFIFLVPPSKKALYERLSRRGTDTPEIVNKRFQKAESEFKLAYKYDYIVVNDDVNNAADR
IMAIIRAEHARTQRTIQKYQQLMEE