ACL_RS01530

Uniprot: A9NEZ8
Description: excinuclease ABC subunit C
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00511299}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): uvrC
Gene names (synonym):
Mass: 67,692
Subunit structure [CC]: SUBUNIT: Interacts with UvrB in an incision complex. {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00511290}.
Gene ontology (GO): cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; nucleotide-excision repair [GO:0006289]; SOS response [GO:0009432]
Gene ontology IDs: GO:0003677; GO:0005737; GO:0006289; GO:0009380; GO:0009381; GO:0009432
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00571147}.; SIMILARITY: Contains 1 GIY-YIG domain. {ECO:0000256|HAMAP-Rule:MF_00203}.; SIMILARITY: Contains 1 UVR domain. {ECO:0000256|HAMAP-Rule:MF_00203}.
Protein families: UvrC family
Coiled coil: COILED 187 214 {ECO:0000256|SAM:Coils}.
Domain [FT]: DOMAIN 10 87 GIY-YIG. {ECO:0000259|PROSITE:PS50164}.; DOMAIN 191 226 UVR. {ECO:0000259|PROSITE:PS50151}.; DOMAIN 242 457 UVRC. {ECO:0000259|PROSITE:PS50165}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NEZ8
MEROPS:
EnsemblBacteria KO: ABX80928
UniPathway: K03703
CDD:
Gene3D:
HAMAP: 3.40.1440.10;4.10.860.10
InterPro: MF_00203
PANTHER: IPR027299;IPR000305;IPR010994;IPR001943;IPR004791;IPR001162
PIRSF:
PRINTS:
PROSITE:
Pfam: PS50164;PS50151;PS50165
ProDom: PF01541;PF02151;PF08459
SMART:
SUPFAM: SM00465
TIGRFAMs: SSF46600;SSF47781;SSF82771

314976-316665(+)

>nucleotide sequence
ATGATGCTTGATCAATCAGGAGAAGTCATTTATGTTGGTAAAGCTAAAAATTTAAAAAAT
AGAGTAAGTTCATACTTTAGAGGCGCACACAATGCTAAAACAGAGAAACTAATTTCAGAG
ATTAGTGATTTTAACTATATCGTCACAAACTCTGAACAAGAATCTCTTATTTTAGAATAC
AATTTAATCAAAAAATATGCACCACTTTATAATATTCGCTTAATTGATGATAAAAGTTAC
CCGTATCTTGAAATCACAAACGAAAAAGATCCAATGCTTGTCGTATCAAGATATATTGAA
GTTGATAAGACTAAAACTTTATTTGGACCTTATCCGAACTCAAAATCAGCAAGAGAAACA
CTAAAACTACTACAACGCCTATATCCATTAAGACGCTGTAATCCAGTAGATAGTAAACCG
TGTTTATATTATCATATGGGTTTATGTTTAGGTCCTTGTGCACATGAAAAGGTAGACTAT
AAACCAAATATTGAACGTATTACTAGGTTTTTAAAGGGTGACACTAAAGAAGTTTTAAAT
GAACTTGAAGAACGCATGAAACAAGCATCAGAAGATTTAGAGTTTGAACGCGCAGTAGAA
TACCGTGATATGATTTTAGCTGTAAAAGATACAACTGAAAAACAGATCATGACGCTAAAT
GATTATAAAGATAGAGACTTTATAAGTTTTGCATATAACGAAGATGATATGGCTATCCAA
ATATTGATGATGCGTCAAGGACGTATATTAGATACACATAAAAATGTGATATCTTATATG
ACTGATCCTTATGAAACGTTTTTAACTTATATTAAAAACTATTATGATAAGTTTTTATTA
CCTGATGAATTGGTGTTTGATCAACAAATCCCTTTTAAAGAACTACAAATGTACTTTAAA
AATAAAGTTGTTGTACCTAAAATAGGAGATAAGAAAAAACTGGTTGATTTAGCACATAAG
AATGCATTAGAAGATTTAACGCATTACTATAAACTATACCGAGCAAAAGAAGAAAAATTA
GGTGAACAAATAGAAGCGTTAGAACAAATATTTGATAAAAAAATATCATATATTGAAGTG
TTTGATAATGCTCACCTATTTGGAACTGCACCTATTTCTGGTATGATAGTTTGGAAAGAT
TATCATTTTGAACGCAAGATGTATCGTAAGTTTCACTTAAAAACTACAACCAATGATGAC
TACCAAGCCATGAAGGAAGTACTTTACCGCAGATATCAAAGACTTTTAGTTGAAAAACAA
AAACTACCAGATTTAATTTGTGTGGATGGTGGTAAAGGACAGGTTTCTGCCGCTTATGAA
GTGATTCAATTATTTAATTTAGATATACCTATTTTAGGTTTGAAAAAAGATAAGTATCAC
ATGCTAGAGGGCTATGTTATCCAAAATGAGGTCACTATTTTGGATAAAAAATCACCACTC
TATCAATTTTTAGGACAACTCTCAGAAGAAGTCCATAGATTTACAATCACTTTCCATCAA
AAGACTAAAAATAGGAAAGACTATACATCGGTTTTAGATAACATACCTGGACTTGGTCCA
ACACGTAAGAAAAAATTACTCGCAAGTTTTAAATCTATTGATGACATTAAAAATGCATCG
ACGGAAGATTTAAGAAGTATTGGATTACCTGATAAGGTAATCAAAAGCATTAAGGAAGGT
ATTTCATGA

>protein sequence
MMLDQSGEVIYVGKAKNLKNRVSSYFRGAHNAKTEKLISEISDFNYIVTNSEQESLILEY
NLIKKYAPLYNIRLIDDKSYPYLEITNEKDPMLVVSRYIEVDKTKTLFGPYPNSKSARET
LKLLQRLYPLRRCNPVDSKPCLYYHMGLCLGPCAHEKVDYKPNIERITRFLKGDTKEVLN
ELEERMKQASEDLEFERAVEYRDMILAVKDTTEKQIMTLNDYKDRDFISFAYNEDDMAIQ
ILMMRQGRILDTHKNVISYMTDPYETFLTYIKNYYDKFLLPDELVFDQQIPFKELQMYFK
NKVVVPKIGDKKKLVDLAHKNALEDLTHYYKLYRAKEEKLGEQIEALEQIFDKKISYIEV
FDNAHLFGTAPISGMIVWKDYHFERKMYRKFHLKTTTNDDYQAMKEVLYRRYQRLLVEKQ
KLPDLICVDGGKGQVSAAYEVIQLFNLDIPILGLKKDKYHMLEGYVIQNEVTILDKKSPL
YQFLGQLSEEVHRFTITFHQKTKNRKDYTSVLDNIPGLGPTRKKKLLASFKSIDDIKNAS
TEDLRSIGLPDKVIKSIKEGISW