ACL_RS01860

Uniprot: A9NF64
Description: undecaprenyl-diphosphatase
EC number: 3.6.1.27
Annotation score: 3 out of 5
Miscellaneous [CC]: MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Ditrans,octacis-undecaprenyl diphosphate + H(2)O = ditrans,octacis-undecaprenyl phosphate + phosphate. {ECO:0000255|HAMAP-Rule:MF_01006}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin. {ECO:0000255|HAMAP-Rule:MF_01006}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): uppP
Gene names (synonym):
Mass: 30,897
Subunit structure [CC]:
Gene ontology (GO): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; undecaprenyl-diphosphatase activity [GO:0050380]; cell wall organization [GO:0071555]; dephosphorylation [GO:0016311]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677]
Gene ontology IDs: GO:0005886; GO:0008360; GO:0009252; GO:0016021; GO:0016311; GO:0046677; GO:0050380; GO:0071555
Chain: CHAIN 1 277 Undecaprenyl-diphosphatase. /FTId=PRO_1000083973.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the UppP family. {ECO:0000255|HAMAP-Rule:MF_01006}.
Protein families: UppP family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: ABX80994
UniPathway: K06153
CDD:
Gene3D:
HAMAP:
InterPro: MF_01006
PANTHER: IPR003824
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF02673
SMART:
SUPFAM:
TIGRFAMs:

391581-392415(-)

>nucleotide sequence
TTAAATAATATATAAAGTAATTGAAACTAGACCAACTGTTAAAGCATATAGAGAAAACCA
AATTAAATTTTTAACAGTGACATATTTGTGCATGATCTTTATAGTTAATAACGAGAAGAT
AAAACTAAATATAAAAGCAAGACTAAATCCTGGGATATCACTCATTGTTCCAGGATTTTT
TATTGCATCATATAATCCTAGACCTGAAACAGGTATACTAATAAGTAAATAACATAGAAA
TGAAAAACGCATAACTTTTTTGATTTCAATTTTTTGACTCAAACCACCCACTAAGGTAAT
ACCTGATCTACTAATACCTGGGAATACTGCAAACATTTGAATTAAACCAATCACACCGGC
ATTTTTAAATGTAATATCATTTGAAAACTTTTTGTTTCTTAAAAGGAAAACTAAGAATAA
TAAGAGTGATGTTATGATAAGAGAAATACCTATGCTTAATAAATTTGTAGGTAGATAGTC
TTTAATGAGTAATCCTGCAATCCCAATAGGCACAATGGCGATAATAAGTTTAACTGCATA
ACTAATGTTTTCTTGAACTATTATTTCTTTTCTTTTTTCTTTATTGAAAACAAAATTAAA
CGAATCGACTACTAACTCTTTAACATCTTTGAAATAATAGATTAGCAAAGCTAGAAATGA
GCCCATATTGGTTATCATTAAAAATAATGTAAGTGTAGCATTTATATCTTCTCCACCTAA
AAATAAATTAGAAAATAATACTAAGTGGCCAGAGCTGGACACTGGAAATATTTCAGTGAC
CCCTTGAATAATACCTAAAATTATATATTTAATTAACTCTATAATGTAATCCAT

>protein sequence
MDYIIELIKYIILGIIQGVTEIFPVSSSGHLVLFSNLFLGGEDINATLTLFLMITNMGSF
LALLIYYFKDVKELVVDSFNFVFNKEKRKEIIVQENISYAVKLIIAIVPIGIAGLLIKDY
LPTNLLSIGISLIITSLLLFLVFLLRNKKFSNDITFKNAGVIGLIQMFAVFPGISRSGIT
LVGGLSQKIEIKKVMRFSFLCYLLISIPVSGLGLYDAIKNPGTMSDIPGFSLAFIFSFIF
SLLTIKIMHKYVTVKNLIWFSLYALTVGLVSITLYII