ACL_RS01985

Uniprot: A9NF88
Description: glycine cleavage system protein H
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor: COFACTOR: Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence={ECO:0000256|HAMAP-Rule:MF_00272}; ; Note=Binds 1 lipoyl cofactor covalently. {ECO:0000256|HAMAP-Rule:MF_00272}
Enzyme regulation:
Function [CC]: FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. {ECO:0000256|HAMAP-Rule:MF_00272, ECO:0000256|SAAS:SAAS00356427}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): gcvH
Gene names (synonym):
Mass: 13,417
Subunit structure [CC]: SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H. {ECO:0000256|HAMAP-Rule:MF_00272, ECO:0000256|SAAS:SAAS00223711}.
Gene ontology (GO): glycine cleavage complex [GO:0005960]; glycine decarboxylation via glycine cleavage system [GO:0019464]
Gene ontology IDs: GO:0005960; GO:0019464
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the GcvH family. {ECO:0000256|HAMAP-Rule:MF_00272, ECO:0000256|SAAS:SAAS00548871}.; SIMILARITY: Contains 1 lipoyl-binding domain. {ECO:0000256|HAMAP-Rule:MF_00272, ECO:0000256|RuleBase:RU000447}.
Protein families: GcvH family
Coiled coil:
Domain [FT]: DOMAIN 21 102 Lipoyl-binding. {ECO:0000259|PROSITE:PS50968}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NF88
MEROPS:
EnsemblBacteria KO: ABX81018
UniPathway: K02437
CDD:
Gene3D:
HAMAP:
InterPro: MF_00272
PANTHER: IPR003016;IPR000089;IPR002930;IPR017453;IPR011053
PIRSF: PTHR11715
PRINTS:
PROSITE:
Pfam: PS50968;PS00189
ProDom: PF01597
SMART:
SUPFAM:
TIGRFAMs: SSF51230

417199-417568(-)

>nucleotide sequence
CTAGAGTGTAGCTTCGTAATCTGTTACATTTAATAATGAATTTGATTCTTCAGGATTTGA
AAGTTCAATTTCTACAATAAAGTTTCCGAATGGATCTTCATTAATAAGTTGAGGTTCTTG
GTCTAGGGCAGTATTTACTGCAAGTACTTTACCAGATAAAGGCATATATAAATCAGATGC
ACTTTTTACAGATTCTACAGCTGCAAAAACATCACCTTTTTTAAATGATTGACCTACTGA
TGGTAAATCAAAGAAAACAATATCACCTAAGTGCATTGCAGCATAAGAAGAAATACCTAC
TTTAGCCTTATTACCCTCGATAAATACCCATTCGTGTGTGTCTAAATATAATACGTCGTT
TTTGTTCAT

>protein sequence
MNKNDVLYLDTHEWVFIEGNKAKVGISSYAAMHLGDIVFFDLPSVGQSFKKGDVFAAVES
VKSASDLYMPLSGKVLAVNTALDQEPQLINEDPFGNFIVEIELSNPEESNSLLNVTDYEA
TL