ACL_RS01990

Uniprot: A9NF89
Description: glycine cleavage system protein T
EC number: 2.1.2.10
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3). {ECO:0000256|RuleBase:RU003981, ECO:0000256|SAAS:SAAS00312915}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000256|RuleBase:RU003981}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): gcvT
Gene names (synonym):
Mass: 40,245
Subunit structure [CC]: SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H. {ECO:0000256|RuleBase:RU003981}.
Gene ontology (GO): aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483]; glycine catabolic process [GO:0006546]
Gene ontology IDs: GO:0004047; GO:0006546; GO:0008483
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the GcvT family. {ECO:0000256|RuleBase:RU003980, ECO:0000256|SAAS:SAAS00567672}.
Protein families: GcvT family
Coiled coil:
Domain [FT]: DOMAIN 9 252 GCV_T. {ECO:0000259|Pfam:PF01571}.; DOMAIN 259 347 GCV_T_C. {ECO:0000259|Pfam:PF08669}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NF89
MEROPS:
EnsemblBacteria KO: ABX81019
UniPathway: K00605
CDD:
Gene3D:
HAMAP: 2.40.30.110;3.30.1360.120
InterPro:
PANTHER: IPR006223;IPR028896;IPR013977;IPR006222;IPR029043;IPR027266
PIRSF:
PRINTS: PIRSF006487
PROSITE:
Pfam:
ProDom: PF01571;PF08669
SMART:
SUPFAM:
TIGRFAMs: SSF101790

417586-418663(-)

>nucleotide sequence
CTATATTTTATTATTTTTATTTATAAATTTTTTATTTCTAACAACCGCTTTAACAAATTT
GTTTCTAATTTTTATATCTATGATTGTACCTAATTTAGCATGTTTTGCATCAATTAATGC
AAACCCTAATGCTATATTCGTAGAAGGCGATAAGTAACCTGTAGTTACATGTCCAATAAG
TTGATTGCCTACATAGATTTCATAACCAGATCTAGCAATATTCTTTTCTAATAACTCAAA
TCCGACATTTTTTCTTAGTGGATTTTCTTTATACGCTAATAATGCAGATTTACCAATGAA
ATCATCCTTTTTAAAATCAACAGCAAACCCTAATCCGGCTTCTATAGGATTTATCGTTTC
ATTCATTTCGTTACCATATAAGGGCATACCAGCTTCAAAGCGTAGCGTGTCTCTAGCACC
TAAACCAATGGGTTTTACACCTAACTTATATAAGTCATCCCAAATTAAAGAAGCATAGCC
ATCATAAGTATATATTTCAAAGCCATCTTCACCTGTATAACCAGATCTGGAAATGAGTAA
GGGACCATGTTCATTATGTGTAAACATAAAGTCTGATGAATGTTTTGGTAAATCTTGAAA
TAATTTACTCAAGAATTTAAAACTGTTTGGACCTTGAACTGCAATACAGTTAAACTTATC
ACTGATATTTCTTAAGTGTATATCAAATGTATGTTTTATTGAAGAAAGATGATTGAAATC
TTTTTCAATATTAGAAGCATTGACTACAAGTAGGATTTGATCAGAACTAAATGGATAAAC
CATTAAGTCATCAATGATACCTCCATCGTTTTGAAGGAGTAATCCATATTGGTTTTGAGG
TCTTAACTCGGTAGTTGAAGATAACACATAATTTGTATAAGCTAGCGCATCTTTACCTTC
AATTAAGATTTGACCCATATGAGATACATCGAACATACCAACATCATTTCTAACCTGATG
GTGTTCTAAGGCGATTGAAGTGTAATATAGTGGCATATGAAATCCACCAAAATCTATTAA
GTTTGCACCTAAATCGACGTGTTTTTGATATAAACTCGTTGTTTTTAATTTATCCAT

>protein sequence
MDKLKTTSLYQKHVDLGANLIDFGGFHMPLYYTSIALEHHQVRNDVGMFDVSHMGQILIE
GKDALAYTNYVLSSTTELRPQNQYGLLLQNDGGIIDDLMVYPFSSDQILLVVNASNIEKD
FNHLSSIKHTFDIHLRNISDKFNCIAVQGPNSFKFLSKLFQDLPKHSSDFMFTHNEHGPL
LISRSGYTGEDGFEIYTYDGYASLIWDDLYKLGVKPIGLGARDTLRFEAGMPLYGNEMNE
TINPIEAGLGFAVDFKKDDFIGKSALLAYKENPLRKNVGFELLEKNIARSGYEIYVGNQL
IGHVTTGYLSPSTNIALGFALIDAKHAKLGTIIDIKIRNKFVKAVVRNKKFINKNNKI