ACL_RS02295

Uniprot: A9NFE8
Description: acetyl-CoA carboxylase subunit beta
EC number: 6.4.1.2
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO:0000255|HAMAP-Rule:MF_01395}.
Cofactor: COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_01395}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01395}
Enzyme regulation:
Function [CC]: FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. {ECO:0000255|HAMAP-Rule:MF_01395}.
Pathway: PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01395}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding: METAL 39 39 Zinc. {ECO:0000255|HAMAP-Rule:MF_01395}.; METAL 42 42 Zinc. {ECO:0000255|HAMAP-Rule:MF_01395}.; METAL 58 58 Zinc. {ECO:0000255|HAMAP-Rule:MF_01395}.; METAL 61 61 Zinc. {ECO:0000255|HAMAP-Rule:MF_01395}.
Nucleotide binding:
Site:
Gene names (primary): accD
Gene names (synonym):
Mass: 32,333
Subunit structure [CC]: SUBUNIT: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). {ECO:0000255|HAMAP-Rule:MF_01395}.
Gene ontology (GO): acetyl-CoA carboxylase complex [GO:0009317]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; zinc ion binding [GO:0008270]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]
Gene ontology IDs: GO:0003989; GO:0005524; GO:0006633; GO:0008270; GO:0009317; GO:2001295
Chain: CHAIN 1 292 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta. /FTId=PRO_0000389653.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the AccD/PCCB family. {ECO:0000255|HAMAP-Rule:MF_01395}.
Protein families: AccD/PCCB family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFE8
MEROPS:
EnsemblBacteria KO: ABX81078
UniPathway: K01963
CDD:
Gene3D:
HAMAP: 3.90.226.10
InterPro: MF_01395
PANTHER: IPR000438;IPR000022;IPR029045;IPR011762
PIRSF:
PRINTS:
PROSITE: PR01070
Pfam: PS50980
ProDom: PF01039
SMART:
SUPFAM:
TIGRFAMs: SSF52096

484950-485778(+)

>nucleotide sequence
ATTATTAAAAAAAGACCTATAGAAACTAGGCCAGTAGATATTCCTGATGGTGTATTTAGT
CAGTGTGAACAATGTAACTCTGCAATCTATAATAAGGATTTAGAACATAACTATGAAGTA
TGTCCTTATTGTAGTTACCATTTTAAAATTAATGCGGTAAAGCGTTTAAAGTATACACTT
GATGAGGATACTTTTAAACCTTTATTTGAGAACATAACATCCAAAAATCCTCTAGGCATG
CCTGAATATGAAGAAAAGTTAGATAAAGGTATGAGAATGGCAAAAATGAATGAAGCATTT
TTAGCAGGAACTGGGAAAATAGATGGTCAAAACTTGGCTATCGGTGTTCTTGATTCATAT
TTTATGATGGGTTCAATGGGTTCAGTTGTAGGGGAGCGTATCACTAGATTAATTGAACAT
GCTGCTAAGCACAATCTACCGCTTGTTATATTTAGTGCATCCGGTGGAGCACGTATGCAA
GAAGGTATTTTAAGTTTAATGCAAATGGCTAAAACATCTGGTGCTTTAAATTTGCTTGAT
GAAAAAGGCTTAGTATACATTTCTGTAATGACGAATCCAACAACCGGTGGTGTTGCTGCA
TCCTTTGCAAGTTTAGGGGATATCAATATTGCTGAAAAATCCAGTTTAATTGGTTTCGCA
GGTGCTAGAGTTATTAAACAAACAATTGGTCAAGATTTACCAGCTGGTTTTCAAACCGAT
GCTTTTCAACTTCAAAAAGGACAAGTGGACTTGGTTGTTTTAAGATCTCAATTGAAAAAG
ACTTTATCAACATTACTTAAACTACATGCTAAGAAGGTGACATCATGA

>protein sequence
IIKKRPIETRPVDIPDGVFSQCEQCNSAIYNKDLEHNYEVCPYCSYHFKINAVKRLKYTL
DEDTFKPLFENITSKNPLGMPEYEEKLDKGMRMAKMNEAFLAGTGKIDGQNLAIGVLDSY
FMMGSMGSVVGERITRLIEHAAKHNLPLVIFSASGGARMQEGILSLMQMAKTSGALNLLD
EKGLVYISVMTNPTTGGVAASFASLGDINIAEKSSLIGFAGARVIKQTIGQDLPAGFQTD
AFQLQKGQVDLVVLRSQLKKTLSTLLKLHAKKVTSW