ACL_RS02300

Uniprot: A9NFE9
Description: acetyl-CoA carboxylase carboxyltransferase subunit alpha
EC number: 6.4.1.2
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO:0000256|HAMAP-Rule:MF_00823, ECO:0000256|SAAS:SAAS00057344}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. {ECO:0000256|HAMAP-Rule:MF_00823, ECO:0000256|SAAS:SAAS00177034}.
Pathway: PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. {ECO:0000256|HAMAP-Rule:MF_00823, ECO:0000256|SAAS:SAAS00057363}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): accA
Gene names (synonym):
Mass: 30,618
Subunit structure [CC]: SUBUNIT: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). {ECO:0000256|HAMAP-Rule:MF_00823, ECO:0000256|SAAS:SAAS00176983}.
Gene ontology (GO): acetyl-CoA carboxylase complex [GO:0009317]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]
Gene ontology IDs: GO:0003989; GO:0005524; GO:0006633; GO:0009317; GO:2001295
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the AccA family. {ECO:0000256|HAMAP-Rule:MF_00823, ECO:0000256|SAAS:SAAS00558839}.
Protein families: AccA family
Coiled coil:
Domain [FT]: DOMAIN 1 252 COA_CT_CTER. {ECO:0000259|PROSITE:PS50989}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFE9
MEROPS:
EnsemblBacteria KO: ABX81079
UniPathway: K01962
CDD:
Gene3D:
HAMAP: 3.90.226.10
InterPro: MF_00823
PANTHER: IPR001095;IPR029045;IPR011763
PIRSF:
PRINTS:
PROSITE: PR01069
Pfam: PS50989
ProDom: PF03255
SMART:
SUPFAM:
TIGRFAMs: SSF52096

485774-486608(+)

>nucleotide sequence
ATGACAGATATGGATAAAGTTTGGCAAAGAGTTAAGTTGGCACGTAGTGCTGATAGGCCA
ACATCAAAGTCACTTATTAAAGCAATCTTCCCTGATTTCATTGAACTACATGGTGATCGT
CTTTACGGCGATGATGAAGCTATTGTAGGTGGACTGGCGACCTTTAATGATATACCAGTT
ACGGTGATTGCTGAAGAAAAGGGTACTGATACACAAAATAGATTAAAACATAATTTTGGT
ATGCCACATCCTGAAGGTTATCGTAAGGCATTAAGATTGATGAAACAAGCCGAGAAGTTT
AAACGTCCTATTATTACAATTATTGATACACCAGGTGCTTATCCGGGACTTGGCGCAGAA
GAACGTGGCCAAGCAGGTGCGATTGCATTAAATTTAAAAGAACTGATGGTGTTAAAAACA
CCTATTATTGTTATTGTATTAGGTGAAGGTGGTTCTGGTGGTGCACTTGCTATAGGTGTA
GGCGATCACATTATGATGTTTGAAAATGCGATATATTCTATATTATCACCTGAAGGATTT
GCTTCAATTTTATTTAAAGATAGTACACGTGCTAATGAGGCTGCTCATTTAATGAAACTT
ACAGCAGAAGATTTAAAATCATTTGGTATTATTGATGAAATCATCTTAGAGGGTAAGGGA
TTAAATACAGACCCTGAAGTCGGTTATACCAATTTAAAGAAACAAATAAGTAAACAACTA
ACAAAATTAATGAAAACACCTGTAGAAAAACTTCTTGTTAATAGATATGACAAGTTCAAA
AAAATGGGTGAATACGAAGAAAGTGTGATCAAAAATGAAGAACTTGCCGATTAA

>protein sequence
MTDMDKVWQRVKLARSADRPTSKSLIKAIFPDFIELHGDRLYGDDEAIVGGLATFNDIPV
TVIAEEKGTDTQNRLKHNFGMPHPEGYRKALRLMKQAEKFKRPIITIIDTPGAYPGLGAE
ERGQAGAIALNLKELMVLKTPIIVIVLGEGGSGGALAIGVGDHIMMFENAIYSILSPEGF
ASILFKDSTRANEAAHLMKLTAEDLKSFGIIDEIILEGKGLNTDPEVGYTNLKKQISKQL
TKLMKTPVEKLLVNRYDKFKKMGEYEESVIKNEELAD