ACL_RS02320

Uniprot: A9NFF3
Description: beta-ketoacyl-[acyl-carrier-protein] synthase II
EC number: 2.3.1.179
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. {ECO:0000256|PIRNR:PIRNR000447}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. {ECO:0000256|PIRNR:PIRNR000447}.
Pathway: PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|PIRNR:PIRNR000447}.
Active site: ACT_SITE 163 163 {ECO:0000256|PIRSR:PIRSR000447-1}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): fabB
Gene names (synonym):
Mass: 44,074
Subunit structure [CC]:
Gene ontology (GO): beta-ketoacyl-acyl-carrier-protein synthase II activity [GO:0033817]; fatty acid biosynthetic process [GO:0006633]
Gene ontology IDs: GO:0006633; GO:0033817
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family. {ECO:0000256|PIRNR:PIRNR000447}.
Protein families: Beta-ketoacyl-ACP synthases family
Coiled coil:
Domain [FT]: DOMAIN 5 401 PKS_KS. {ECO:0000259|SMART:SM00825}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFF3
MEROPS:
EnsemblBacteria KO: ABX81083
UniPathway: K09458
CDD:
Gene3D:
HAMAP: 3.40.47.10
InterPro:
PANTHER: IPR017568;IPR018201;IPR014031;IPR014030;IPR020841;IPR016039
PIRSF:
PRINTS: PIRSF000447
PROSITE:
Pfam: PS00606
ProDom: PF00109;PF02801
SMART:
SUPFAM: SM00825
TIGRFAMs: SSF53901

489211-490450(+)

>nucleotide sequence
ATGAAAAGAAGAGTCGTTATTACAGGGATGGGTACAATTAACCCTGTTGGTAATAGTGTA
GATGAATCATTTGATGCCATTATTGATGGTAAGAATGGATTAGGTCCAATTACTTATTTT
GATACTGAAAAGGTAAAAATAAGTATTGCTGGTGAATTAAAAAACATTAATTTTGAAGAT
TACCTAGATAAAAAAGAAATTAAACGTAGTGATAAAGTCATGATTTTAGGTACGATTGCA
GCCATGCAAGCATACGAGGATAGCGGACTAAAAGACACTGATTATGACCCATATAGATTT
GGTACGTTTGTAACATCTGGAATTGGTGGACTAGATACTATGGAAAAAGATATTTCTATA
AAAGCACTACGTGGTGCTGATAGAATTTCACCTTTTTTCATACCAAATTCTATTGTAAAT
ATGGTAGGTGGTATGATATCTATTAAGTTCCAAGTAAAGGGTCCAAATATACCGATTGTT
ACAGCATGTTCAGCTGCAACAAATGCAATAGGTGAAGCATTCAGAAATATCCGTGATGGA
TATTTAGATTTAGCTTTCGCAGGTGGTGCAGAGGCAAGTATAAATGAAACTGGTATCGGT
GGATTTGCAGCTTTAAAAGCACTTTCAACTGAAACAGATCCTAATAAAGCAAGTCGTCCT
TTCGATAAAGAAAGAAGTGGCTTTGTAATGGGAGAAGGTTCAGGGGTTCTTATTTTAGAA
TCTTTAGAAAGTGCCCAAAAACGTGGTGCTAAAATCTATGCTGAAATCGTTGGTTATGGT
TCAACATCAGATGCATTCCATATGACTGCACCAGATAATGCTGCTGATGGATTAACTAAG
GCTATTGAGTTAACACTTGAAGATGCTAAAGTATCACCAACTGACGTTGGATATATCAAT
GCACACGGTACATCCACATTACTAAATGATAAAATTGAAACACTAGGTATTAAACGTGCT
TTTAAAGAACATGCATACGATTTGAATGTATCTTCTACAAAAGGTGCAACAGGCCATATG
TTAGGTGCAACCGGTGCAGTAGAAAGTATCTTTTGTATCAAAGCACTACAAACAGGTTTA
ATTCCACCAACAATCAACTACAGTAATGTAGATCCTGAATGTGACTTAAACTATACAGTA
AACAAAGCCGTAAAACGTGATATCAATTATGCTATGAATATCAACGTAGGTTTTGGTGGC
CAAAATGCAGTTGTGTTATATAAGAAATATGGAGAATAA

>protein sequence
MKRRVVITGMGTINPVGNSVDESFDAIIDGKNGLGPITYFDTEKVKISIAGELKNINFED
YLDKKEIKRSDKVMILGTIAAMQAYEDSGLKDTDYDPYRFGTFVTSGIGGLDTMEKDISI
KALRGADRISPFFIPNSIVNMVGGMISIKFQVKGPNIPIVTACSAATNAIGEAFRNIRDG
YLDLAFAGGAEASINETGIGGFAALKALSTETDPNKASRPFDKERSGFVMGEGSGVLILE
SLESAQKRGAKIYAEIVGYGSTSDAFHMTAPDNAADGLTKAIELTLEDAKVSPTDVGYIN
AHGTSTLLNDKIETLGIKRAFKEHAYDLNVSSTKGATGHMLGATGAVESIFCIKALQTGL
IPPTINYSNVDPECDLNYTVNKAVKRDINYAMNINVGFGGQNAVVLYKKYGE