ACL_RS02380

Uniprot: A9NFG5
Description: exodeoxyribonuclease VII large subunit
EC number: 3.1.11.6
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. {ECO:0000255|HAMAP-Rule:MF_00378}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): xseA
Gene names (synonym):
Mass: 50,804
Subunit structure [CC]: SUBUNIT: Heterooligomer composed of large and small subunits. {ECO:0000255|HAMAP-Rule:MF_00378}.
Gene ontology (GO): cytoplasm [GO:0005737]; exodeoxyribonuclease VII complex [GO:0009318]; exodeoxyribonuclease VII activity [GO:0008855]; nucleic acid binding [GO:0003676]; DNA catabolic process [GO:0006308]
Gene ontology IDs: GO:0003676; GO:0005737; GO:0006308; GO:0008855; GO:0009318
Chain: CHAIN 1 446 Exodeoxyribonuclease 7 large subunit. /FTId=PRO_1000200654.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-Rule:MF_00378}.
Protein families: XseA family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: ABX81095
UniPathway: K03601
CDD:
Gene3D:
HAMAP:
InterPro: MF_00378
PANTHER: IPR003753;IPR020579;IPR025824
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF02601;PF13742
SMART:
SUPFAM:
TIGRFAMs:

499663-501004(+)

>nucleotide sequence
ATGAACGAACAAAAGTATTTAAGCGTTTCGGCACTAACTGAATATATTAAAGTCAAATTA
GAAAATGATAACCATCTTAAACGCGTATTTTTAAAAGGTGAAATTTCAAATTTTACGCAT
CATGGTTCAGGACATCTGTATTTTTCATTAAAAGATGAAGATGCAGCAATCTCTGCAATG
ATGTTTAAAACGTATGCATCTACATTAAGTTTTAAACCTAAAGCAGGGGATAAAGTATTA
GTAGAAGGTTATATTTCTTTATATAAAGCACGTGGTACGTATAGTATCTCGATTTTTTCT
ATGACACTCGATGGTATTGGTGAGCTCTTCTTAAAATATGAACAAAATAGAAAGATGTTT
CAAGAATTAGGCTATTTTGATGAATCACTAAAAAAACCTATTCCTAAGTTTCCTAAGATT
ATTGCAGTCATTACATCTGAAACTGGTGCAGTGATTCAAGATATAAAAACAACCATTTCA
AGACGTTACTTACTCGCGAAAATTGAACTCTATCCTATTTTAGTTCAAGGTGAAGGTTCT
AAAGACGATATTGTTAAAACACTAGCAAGAGTCAACAGAGAAAGTCAAGCAGATGTCATT
ATCTTAGGACGCGGTGGTGGGTCGATTGAAGACTTATGGAGTTTTAATGAGGCTGAAGTC
GTTGTTGCAATTCATCAGTCTAAAATACCTGTTATTACAGCAATAGGACATGAAACAGAT
ACAACCCTATCTGATTATGTTTCAGACTTACGTGCACCAACACCAACAGCTGCAGCAGAA
CTTGCTACACCGAATATGGCGGACTTAATTAAAGAAATAAAAGACAAAGTTCAATTAAGT
CAGTACTATATGAATGAGCGTATAAAAAACTATACTGCATTAATACTTAATTTAGATGAA
AGACTTGAACTAGCCAGTCCTAAATCCAAGTTAGAGTTAGAACATAAACAAATTGATAAC
TTAACATCTAAATTAACGTACTTTTATAAGTCAAAACTAACAGATAACTTAAATCAGGTC
AGACTTTTAAGTCAAAGACTTACGTCGCCTGATGAAAAAATAGAACGTTATAAAGAACGT
ATAGAAACATTAACATCCAGAATAAACCTTTTATATAAGAAGCAAGTAGACTTGAAAACT
TACGAATATCAATCAAGTCTAAAGCAACTACAAGGACTAGATCCATTACGTATTATGCAA
AGAGGTTTCTCATTAACAACCAAAAATCAAAAAGTGATTACAAGTATAGAACAAATCAAT
ACGAATGATGAATTAGATATTCAATATAAAGATGGTACAGCCAAGGTTAAAGTATTAAGC
AAGGAAGGTAAACACATATGA

>protein sequence
MNEQKYLSVSALTEYIKVKLENDNHLKRVFLKGEISNFTHHGSGHLYFSLKDEDAAISAM
MFKTYASTLSFKPKAGDKVLVEGYISLYKARGTYSISIFSMTLDGIGELFLKYEQNRKMF
QELGYFDESLKKPIPKFPKIIAVITSETGAVIQDIKTTISRRYLLAKIELYPILVQGEGS
KDDIVKTLARVNRESQADVIILGRGGGSIEDLWSFNEAEVVVAIHQSKIPVITAIGHETD
TTLSDYVSDLRAPTPTAAAELATPNMADLIKEIKDKVQLSQYYMNERIKNYTALILNLDE
RLELASPKSKLELEHKQIDNLTSKLTYFYKSKLTDNLNQVRLLSQRLTSPDEKIERYKER
IETLTSRINLLYKKQVDLKTYEYQSSLKQLQGLDPLRIMQRGFSLTTKNQKVITSIEQIN
TNDELDIQYKDGTAKVKVLSKEGKHIW