ACL_RS02430

Uniprot: A9NFH4
Description: arginine--tRNA ligase
EC number: 6.1.1.19
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). {ECO:0000256|HAMAP-Rule:MF_00123}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): argS
Gene names (synonym):
Mass: 64,265
Subunit structure [CC]: SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00123}.
Gene ontology (GO): cytoplasm [GO:0005737]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; arginyl-tRNA aminoacylation [GO:0006420]
Gene ontology IDs: GO:0004814; GO:0005524; GO:0005737; GO:0006420
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO:0000256|HAMAP-Rule:MF_00123, ECO:0000256|RuleBase:RU363038}.
Protein families: Class-I aminoacyl-tRNA synthetase family
Coiled coil:
Domain [FT]: DOMAIN 10 83 Arg_tRNA_synt_N. {ECO:0000259|SMART:SM01016}.; DOMAIN 445 559 DALR_1. {ECO:0000259|SMART:SM00836}.
Motif: MOTIF 120 130 "HIGH" region. {ECO:0000256|HAMAP-Rule:MF_00123}.
Region:
EMBL: CP000896
ProteinModelPortal: A9NFH4
MEROPS:
EnsemblBacteria KO: ABX81104
UniPathway: K01887
CDD:
Gene3D:
HAMAP: 1.10.730.10;3.30.1360.70;3.40.50.620
InterPro: MF_00123
PANTHER: IPR001278;IPR005148;IPR008909;IPR014729;IPR009080
PIRSF: PTHR11956
PRINTS:
PROSITE: PR01038
Pfam:
ProDom: PF05746;PF00750
SMART:
SUPFAM: SM01016;SM00836
TIGRFAMs: SSF47323;SSF55190

508237-509908(+)

>nucleotide sequence
ATGATAGAGCAAATTAAATTAGAGCTCAGACAATTATTATTTGATCATTTAGATATAGAA
GATGTTGTATTAGAAGTACCTAAAAGGGGCGATTCTGATTTAGCAATTCCATTATTTGGA
TATCAAAAACAAATGGGTAAAAAATTACCTGAAATCTTTGACTTATTTAAAGATATATTA
ATTCAACATCGTTTAGTAGAATCTGTAGTATTTACTGCAGGGTTTTTAAACATCTATCTA
AAACGAGTGGATGTATCCAAATCTATTTTAAATTCAATACATGATGAGAAGCAATCCTTT
GGTACACAACCAAATAATAATAAAACTATTGTTATCGACTATTCCTCACCTAATATTGCT
AAAAGCTTTAGCGTTGGTCATTTACGTTCAACGGTTATCGGTAATAGTTTAAAATTAATT
TACCAAAAATTAGGTTATAACGTTGTAGGGATTAATCACCTAGGTGATTGGGGTACACAA
TTTGGATCTATGATGGTTGCATACCGTATGTGGGGCGACAAAGATAAAATTAAGGCTAAT
CCTATTGATGAGCTTCAAGCACTTTATGTGCGTTTTCACGAGGCAGCTGAAAAAGATGAA
TCATTAAAACAAAAGGCTCGCGATGCTTTCTTAAAACTAGAACAAGGGGATCCAGAATAC
ACAAAATTATGGACATATTTTAGAGAAGTATCCCTGCAAGAATTTATGACTATGTATGAT
ATTTTAGATGTTAGTTTTGATAGTTATAATGGTGAAGCATTCTATAATGATAAAATGGAT
AGAGTAGTTAAAGAATTAGAAGATAAACATTTACTCGTCGAAGATCAAGGTGCGATGGTT
GTCAAATTAGAAGATGACACACCACCTGTACTAATTAAAAGAAGTGATGGTGCAACACTA
TATACTACAAGAGATCTAGCAGCACTACTGTATAGAAATGATACATATCATTTTGATAAG
GCATTATATGTTGTTGGTAATGAACAAAAACTCCATTTTGAAAACTTGAAGAAAGTTGTC
AAAATGATGGGTTATGATTTTAATATTGAACACATTAATTTTGGCCTTGTTTTACAAGAT
GGTAAAAAGATGTCTACTAGAAAAGGTAAGACAACAAAGTTAGACTATGTGTTAAATCAA
GCCGTATTAAAAGCAAAACAAGCAATTGAAGAAAAGAATCCCAACTTAGAAAATAAAGAT
CAAGTAGCCAAAGTTGTAGGTATTGGTGCTGTTATCTTTAATGACCTTAAAAATGATAGA
ACTTTAAATATTGAATTTGATTTAGATGGTATGCTTAAGTTTGAAGGACAAACTGGGCCA
TATCTGTTATATTCTATCGTAAGAATTTTCTCTATTCTAAAATCAAATACAATAGATATT
ACTCAAGTAGACTATACACTATATCAAGATGAAATCTATTATAGTTTAATTAAAGTACTT
GATCAATTCCCAAGTGTTGTACAAAGAGCAGCAGAAAGTTATTCACCATCTACAGTAGCT
AAATATTTATTACAATTATCACAAGAATTTAATACATTTTATGCTAAAGTAAAAATTAAT
GATAGTAATGATGTTGTAAGACAAACAAATCTATTATTAGTAGAAAGTATTTTAAATATC
TTAATCGAGGGTTTAAGACTTCTAGGTATGAAACATTTAGAAGCAATGTAA

>protein sequence
MIEQIKLELRQLLFDHLDIEDVVLEVPKRGDSDLAIPLFGYQKQMGKKLPEIFDLFKDIL
IQHRLVESVVFTAGFLNIYLKRVDVSKSILNSIHDEKQSFGTQPNNNKTIVIDYSSPNIA
KSFSVGHLRSTVIGNSLKLIYQKLGYNVVGINHLGDWGTQFGSMMVAYRMWGDKDKIKAN
PIDELQALYVRFHEAAEKDESLKQKARDAFLKLEQGDPEYTKLWTYFREVSLQEFMTMYD
ILDVSFDSYNGEAFYNDKMDRVVKELEDKHLLVEDQGAMVVKLEDDTPPVLIKRSDGATL
YTTRDLAALLYRNDTYHFDKALYVVGNEQKLHFENLKKVVKMMGYDFNIEHINFGLVLQD
GKKMSTRKGKTTKLDYVLNQAVLKAKQAIEEKNPNLENKDQVAKVVGIGAVIFNDLKNDR
TLNIEFDLDGMLKFEGQTGPYLLYSIVRIFSILKSNTIDITQVDYTLYQDEIYYSLIKVL
DQFPSVVQRAAESYSPSTVAKYLLQLSQEFNTFYAKVKINDSNDVVRQTNLLLVESILNI
LIEGLRLLGMKHLEAM