ACL_RS02465

Uniprot: A9NFI0
Description: nicotinate phosphoribosyltransferase
EC number: 6.3.4.21
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. {ECO:0000256|SAAS:SAAS00075180}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. {ECO:0000256|SAAS:SAAS00564912}.
Pathway: PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. {ECO:0000256|SAAS:SAAS00075156}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): pncB
Gene names (synonym):
Mass: 54,643
Subunit structure [CC]:
Gene ontology (GO): ligase activity [GO:0016874]; nicotinate phosphoribosyltransferase activity [GO:0004516]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]; NAD biosynthetic process [GO:0009435]; nicotinate nucleotide salvage [GO:0019358]
Gene ontology IDs: GO:0004514; GO:0004516; GO:0009435; GO:0016874; GO:0019358
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the NAPRTase family. {ECO:0000256|SAAS:SAAS00564904}.
Protein families: NAPRTase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFI0
MEROPS:
EnsemblBacteria KO: ABX81110
UniPathway: K00763
CDD:
Gene3D:
HAMAP:
InterPro:
PANTHER: IPR007229;IPR006405;IPR002638
PIRSF: PTHR11098
PRINTS: PIRSF000484
PROSITE:
Pfam:
ProDom: PF04095
SMART:
SUPFAM:
TIGRFAMs: SSF51690

514789-516226(+)

>nucleotide sequence
ATGAAACGAAATTTAGCGTTATTAACAGACTTTTATGAACTGACTATGTCCAATGGATAT
TTCAAAGATAACCGCCATAATCAAGTGGCAGTATTTGATGTATTCTTTAGAAGTATTCCA
GATGATGGCGGTTATGCAATATTTGCTGGTCTAGAATCTATTATTGAATACATTAAGAAT
TTAACATTTGATAAAGAATCAATTGAATTTTTAAGAAATAAAAAAATATTTGATGAAGGT
TTTTTAACTTATTTAGAAAACTTTAAATTTACCTCTGATGTTTACGCGATCAAAGAAGGT
ACTCCAATTTTCCCTAATGAACCATTAATGGTTATTAAAGGACCTATCATTGAATGTCAA
CTCATTGAAACATTTGTACTACTTTCAATTAATCATCAATCCTTGATTGCAACAAAGGCA
TCAAGAATTGTAAGAGAAGCAAAAGGTAGACCAGTCTTTGAATTTGGTGCAAGAAGAGCA
CATTCTTATGATGCAGCAAATCTAGGTGCTAGAAGTGCATATATTAGTGGTGTTACAGGT
ACGTCAAATACCTTAGCTGACTTTATGTATGGCATTCCATCTTCTGGTACAATGGCACAT
TCCTATGTTCAAAGTTTTCCTAGTGAATATGAAGCATTTAAGAGCTATGCCCTAAATTAC
CCAGATAACTGTTTATTATTAGTAGATACCTATGATACTTTACATGAAGGTATTCCAAAT
GCTATAAGAATTCATAATGAAGTTTTAAAGCCAATGGGTAAATACTTAAAAGGTATTCGA
ATTGATTCGGGTGACTTAGCTTATTTATCTAAGAAAGTACGTGCTTTATTAGATGAAGCA
GGTCTAACTGAAACTAAGATTACTGTATCGAACTCATTGGATGAGTTTATTATCAGAGAC
TTGATCGTACATCAAGAAGCAGAAATCGATGCTTTTGGTGTCGGTGAAAGATTAATCACT
GCAAGAAGTGAGGCGGTCTTTGGTGGTGTATTTAAGTTAAGTGCAATTGAAGAAAACGGT
CAAATTGTGCCGAAAATTAAAATTTCTGATAATGTTGCAAAAACAACTATTCCAGGATTT
AAGCAACTTTATCGCTTCTATGATGAAAATGATATGGCCATAGCAGATGTCATTACACTT
CACAATGAAGAAATAGATCCATCTAAACCATATACATTATTTGATCCAAATCATCCTTGG
AAACAAAAGGTGGTAGAAAAATATAGAGTAGAAAAACTTTTAGTACCTATCTTTGAAAAA
GGTAAACTAGTTTATGAACTACCTTCAATAGAAGCAATTAGAAAACATAAAGAAATTAAT
TTTAATAAACTTTGGAAAGAAGTAATACGTTTAAAGTTTCCACATGAATACTATGTTGAT
TTATCACAAGATTTATGGGATTTACGACGAGCATTAGTAGTTAAGCATAAACATTAG

>protein sequence
MKRNLALLTDFYELTMSNGYFKDNRHNQVAVFDVFFRSIPDDGGYAIFAGLESIIEYIKN
LTFDKESIEFLRNKKIFDEGFLTYLENFKFTSDVYAIKEGTPIFPNEPLMVIKGPIIECQ
LIETFVLLSINHQSLIATKASRIVREAKGRPVFEFGARRAHSYDAANLGARSAYISGVTG
TSNTLADFMYGIPSSGTMAHSYVQSFPSEYEAFKSYALNYPDNCLLLVDTYDTLHEGIPN
AIRIHNEVLKPMGKYLKGIRIDSGDLAYLSKKVRALLDEAGLTETKITVSNSLDEFIIRD
LIVHQEAEIDAFGVGERLITARSEAVFGGVFKLSAIEENGQIVPKIKISDNVAKTTIPGF
KQLYRFYDENDMAIADVITLHNEEIDPSKPYTLFDPNHPWKQKVVEKYRVEKLLVPIFEK
GKLVYELPSIEAIRKHKEINFNKLWKEVIRLKFPHEYYVDLSQDLWDLRRALVVKHKH