ACL_RS02685

Uniprot: A9NFM3
Description: trigger factor
EC number: 5.2.1.8
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). {ECO:0000256|HAMAP-Rule:MF_00303}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. {ECO:0000256|HAMAP-Rule:MF_00303}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): tig
Gene names (synonym):
Mass: 48,265
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein folding [GO:0006457]; protein transport [GO:0015031]
Gene ontology IDs: GO:0003755; GO:0005737; GO:0006457; GO:0007049; GO:0015031; GO:0051301
Chain:
Signal peptide:
Domain [CC]: DOMAIN: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own. {ECO:0000256|HAMAP-Rule:MF_00303}.
Sequence similarities: SIMILARITY: Belongs to the FKBP-type PPIase family. Tig subfamily. {ECO:0000256|HAMAP-Rule:MF_00303, ECO:0000256|RuleBase:RU003914}.; SIMILARITY: Contains 1 PPIase FKBP-type domain. {ECO:0000256|HAMAP-Rule:MF_00303}.
Protein families: FKBP-type PPIase family, Tig subfamily
Coiled coil:
Domain [FT]: DOMAIN 163 248 PPIase FKBP-type. {ECO:0000259|PROSITE:PS50059}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFM3
MEROPS:
EnsemblBacteria KO: ABX81153
UniPathway: K03545
CDD:
Gene3D:
HAMAP: 1.10.3120.10;3.30.70.1050
InterPro: MF_00303
PANTHER: IPR001179;IPR005215;IPR008880;IPR008881;IPR027304
PIRSF:
PRINTS: PIRSF003095
PROSITE:
Pfam: PS50059
ProDom: PF00254;PF05698;PF05697
SMART:
SUPFAM:
TIGRFAMs: SSF102735;SSF109998

568985-570269(+)

>nucleotide sequence
ATGAAATTTGAACATATAAAAAAGAATCATGTAAAATTTACTTTTACAGTAACACCTGCA
GAATTTGAACATGCATTAGAACATGCTTTTGCACACATTAAAGATGATGTAGAAATTAAA
GGATTTAGAAAAGGTAAAGTAACTCAAAAAGTTTACGAACAAAAATTTGGTGAAACAGCA
TTATATGCAGAAGCATTAAACCACGCAATTGGTCATAAATATAATGATGCTACACTAGTA
AAAGACTTTACAATTGTTTCAGATCCAATGAATATTGATCTAGATTTCGATAAAATCTCA
AGAACAGAAGATTTTGAAGTAAGTTTTGAAGTTGCAATCAAACCTGAAGTTGAAATTGAA
AACTATAAAGGTGTTGAAGTTGCTAAAGTAGATACAGAAGTAACAGAAAAAGAAGTTGAT
GAAAACATTAACAGCCTATTAGCTCAAAATGCTATTTTAGAACCTAAAGAAGGTGCACTA
GAAAATGGCGATACAGCAATCTTTGATTTCGAAGGATTCCAAGATGGTGTTGCATTTGAA
GGTGGGAAAGCTGAAAACTTCAGTTTAGAAATCGGTAGTGGTCAATTCATTCCTGGTTTT
GAAGAAGGTATGTTAGGCTTAAAAGTTGGTGAATCACGCGATGTGGATGTTACTTTCCCT
GAACAATACCAAGCTGAAAACCTAGCAGGTAAACCGGCAGTATTTAAAGTTGTATTACAC
GAAATTAAATCTAAAAAATTAGCAGAATTAAATGATGAATGGGTTGTATCACTTAACCGT
GAAGGTATCTCAACTGTTGATCAATTAAAAGCATCAATCAAAGCAGATTTAGAAGCATCT
AAACAAGAACAAGCTAAAAGAGAATTAACTGATGCAGTTATCACTGAAGTAGTTAAATTA
GCTAAAGTTGAAGTGCCACAATCTATGTTTGATTCAGAAATCGAAAACTTCAAGAAAAAT
GTTGAAGCTCAAGCTAAACAATATCAATTAGATATGGATACATTCATCCAATTATCAGGA
TTAACTAAAGAATTATTCGAACAACAAGCTAAAGAACAAGCTGAAAAACGTGTACTTCAA
TCTCTAGTAATCGAAGCGATTGCTAAGAAAGAAAACTTCACTGCTACACCTGAAGAATTA
AGTTTGCGTTATGAAGAATTAGCAAACCATTACAAAATGGAAGTTAATGAAATTAAAAAG
TATATCTCAGATGAACTAGTAATGAATGATATCGCATTTGAAAAAGCAGTAACATTCTTA
GTAGAAAACGCAGTACAAAAATAA

>protein sequence
MKFEHIKKNHVKFTFTVTPAEFEHALEHAFAHIKDDVEIKGFRKGKVTQKVYEQKFGETA
LYAEALNHAIGHKYNDATLVKDFTIVSDPMNIDLDFDKISRTEDFEVSFEVAIKPEVEIE
NYKGVEVAKVDTEVTEKEVDENINSLLAQNAILEPKEGALENGDTAIFDFEGFQDGVAFE
GGKAENFSLEIGSGQFIPGFEEGMLGLKVGESRDVDVTFPEQYQAENLAGKPAVFKVVLH
EIKSKKLAELNDEWVVSLNREGISTVDQLKASIKADLEASKQEQAKRELTDAVITEVVKL
AKVEVPQSMFDSEIENFKKNVEAQAKQYQLDMDTFIQLSGLTKELFEQQAKEQAEKRVLQ
SLVIEAIAKKENFTATPEELSLRYEELANHYKMEVNEIKKYISDELVMNDIAFEKAVTFL
VENAVQK