ACL_RS02720

Uniprot: A9NFN0
Description: folylpolyglutamate synthase
EC number: 6.3.2.17
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): folC
Gene names (synonym):
Mass: 46,614
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326]
Gene ontology IDs: GO:0004326; GO:0005524
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the folylpolyglutamate synthase family. {ECO:0000256|PIRNR:PIRNR001563}.
Protein families: Folylpolyglutamate synthase family
Coiled coil:
Domain [FT]: DOMAIN 46 262 Mur_ligase_M. {ECO:0000259|Pfam:PF08245}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFN0
MEROPS:
EnsemblBacteria KO: ABX81160
UniPathway: K11754
CDD:
Gene3D:
HAMAP: 3.40.1190.10;3.90.190.20
InterPro:
PANTHER: IPR001645;IPR018109;IPR004101;IPR013221
PIRSF: PTHR11136
PRINTS: PIRSF001563
PROSITE:
Pfam: PS01011;PS01012
ProDom: PF08245
SMART:
SUPFAM:
TIGRFAMs: SSF53244;SSF53623

578306-579542(+)

>nucleotide sequence
ATGTTTAAACAACTTGATGAAGCAGTAAATTGGATAGAAACACAAATAAAGTTTAGACCT
AAAACAAGCCTAGATCATATGAAGGATGCCTTAAGCATCCTTCAGCTTGATTTAAGCGGT
ATCAAAAAGATTCATGTCACTGGTACAAATGGTAAGGGCTCAGTTTGTATGATGACTACT
CAAGTACTGGTTGAATCCGGTATCCGCGTAGGAACTTTCATATCACCTTATTTGGTACGC
TTTAACGAACGCATTAAACTCAATGGTAAAGATATAGAAGATAATGATTTATTGGATTCT
ATTAATAAAGTTTATGAGCTAAACAATGCATATTTTGAACATAGTGGGCTAACACTATCG
TTTTTTGAACTGATGACTCTCATGTCACTGATTTACTTTGTAGATAATAAGGTCGATGTT
ATCGTGATGGAAGTTGGTATTGGTGGTCTCTTAGATGCTACAAATATATTAAATTATGAT
GTCTCAGTCATTACCAATGTTGGAATGGATCATATGCGTCAATTAGGTAATACATTAGAA
TCGATTGCATTAAACAAACTTGGCATTTTAAAAGAAAAGGGTCACTTAATTACGAGTATC
GACAGTGGATTACATGATTTAGTTAAGGATTATGTATCAAAAATGCATTCAACACTTAAA
ATTATTCAAAAACATGATGTAACCACTATATCCGAGTTTCCTCACAAAATTGAATATAAT
CACCAAATATATAAACTATCATTGTTAGGCGAGTTTCAAAACACTAATGCAGCGCTTGTT
ATAGAAGTTATTAAATATTTATTTCCAAATATAACTGAGCAAACAATTAGTGAAGGTTTA
AGTAAAACTGAACACCCAGGACGCTTAGAAACAGTGTTGCCTGGAGTGGTTTTAGATGGT
GCCCATAATATTCATGCAATTAAGGAAGTCATTTTTTCGCTAAAATCTATTTTTAAAGTG
TATAATATACATGTACTATTCAGTGCACTATCTGATAAAGAGCCTGAAGTGATGCTAAAT
GAACTCAAAAAATATGCAACAACCATCACTTTGACTGCTTTTCCGGATGCTCGTTATAAA
AACCTAGATTTTCTTCCCTTTAACTTTGAATTGAATCCTAAAACAGCTTTAAAAAATTTA
ATCAAGAACAAAAAAGAAAATGACGTTATTTTTATAACTGGTAGTTTGCACTTTATTGGG
TATATGAAAAAGGAAATTATTCCGTACTTTAAATAA

>protein sequence
MFKQLDEAVNWIETQIKFRPKTSLDHMKDALSILQLDLSGIKKIHVTGTNGKGSVCMMTT
QVLVESGIRVGTFISPYLVRFNERIKLNGKDIEDNDLLDSINKVYELNNAYFEHSGLTLS
FFELMTLMSLIYFVDNKVDVIVMEVGIGGLLDATNILNYDVSVITNVGMDHMRQLGNTLE
SIALNKLGILKEKGHLITSIDSGLHDLVKDYVSKMHSTLKIIQKHDVTTISEFPHKIEYN
HQIYKLSLLGEFQNTNAALVIEVIKYLFPNITEQTISEGLSKTEHPGRLETVLPGVVLDG
AHNIHAIKEVIFSLKSIFKVYNIHVLFSALSDKEPEVMLNELKKYATTITLTAFPDARYK
NLDFLPFNFELNPKTALKNLIKNKKENDVIFITGSLHFIGYMKKEIIPYFK