ACL_RS02750

Uniprot: A9NFN6
Description: HrcA family transcriptional regulator
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): hrcA
Gene names (synonym):
Mass: 38,994
Subunit structure [CC]:
Gene ontology (GO): DNA binding [GO:0003677]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]
Gene ontology IDs: GO:0003677; GO:0006351; GO:0045892
Chain: CHAIN 1 342 Heat-inducible transcription repressor HrcA. /FTId=PRO_1000075278.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-Rule:MF_00081}.
Protein families: HrcA family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFN6
MEROPS:
EnsemblBacteria KO: ABX81166
UniPathway: K03705
CDD:
Gene3D:
HAMAP: 1.10.10.10;3.30.450.40
InterPro: MF_00081
PANTHER: IPR029016;IPR002571;IPR021153;IPR011991
PIRSF:
PRINTS: PIRSF005485
PROSITE:
Pfam:
ProDom: PF01628
SMART:
SUPFAM:
TIGRFAMs: SSF46785;SSF55781

584061-585090(+)

>nucleotide sequence
ATGATATCGTCAAGACAAAAACTCATCTTAAAAGCAATCATTGATATGTATTCTGAAAAG
GGTGAACCGGTAGGTTCTAAAGCCTTAATGGCGCTTCCATACTTAAATTACTCATCAGCT
ACATTAAGATATGATATGGCAGTTTTAGAAGAACTAGGTTTTCTCGAGAAGATGCATACT
TCATCAGGTAGAGTACCTTCTGAACGTGGTTATCGTTACTATATTGAACATTTAGTGACA
AGGGATAATGATGTGACAGAAGTATTTCCTTTAATCGATGAAGTTTTTAGTAAAAAAGCA
CTTGGTCGTGAACACACGATTAAAGAAGCATTAAAGTTACTAACCGATCTTACAAGCTAC
ACAGCTGTTGCAGTAGGACCAGATATCTTACAATCTCATATTAAGCGTATTGAAATGGTA
CCACTTGGTTTAAAAGATGCAGTCATGTTAATTGTAACCGACACAGGGCACGTACAACAT
CAACAAATTCATATATCAGATGATATGAGAATGGATGATATTAAGGAAGTTATACATACA
CTGGATGACTTACTTAAGAATAGAACACTAGAAGATGCACTTAAGGTACTCAAAGAGGAA
TATGCAATTTCTGAACTGAATCAATTTATGAGCTATCAAAGTCAAATCATTGATTCATTC
ATTGAAGCATTTTCTAAATTTGCATCAGATTCCTTCTATTTAAGTGGTATGACGAATGCT
TTTGAACAACCAGAATTTAATGATGTTTCTCATATGAAACGATTTATAGATATGATGGAT
CGTCGTGAAATTGTGAAGTTGATTGGAACTGCTGAAGGCATATCAGTAAGATTTGGGTCA
GATATGGAAATCAAACCCTTAAATCAAATGACAATCATTTCTATACCTTATCAAATAGAT
TCAAAACAAAAAGGAACGATTGCACTTGTAGGACCTTCAAGAATGTCTTATCAAAAGGTA
ATCCCCTTGTTAGAGTACATTGCAGCAAATCTAGCAAAACTATATAAAGACAATAATAAG
GAGACTTAG

>protein sequence
MISSRQKLILKAIIDMYSEKGEPVGSKALMALPYLNYSSATLRYDMAVLEELGFLEKMHT
SSGRVPSERGYRYYIEHLVTRDNDVTEVFPLIDEVFSKKALGREHTIKEALKLLTDLTSY
TAVAVGPDILQSHIKRIEMVPLGLKDAVMLIVTDTGHVQHQQIHISDDMRMDDIKEVIHT
LDDLLKNRTLEDALKVLKEEYAISELNQFMSYQSQIIDSFIEAFSKFASDSFYLSGMTNA
FEQPEFNDVSHMKRFIDMMDRREIVKLIGTAEGISVRFGSDMEIKPLNQMTIISIPYQID
SKQKGTIALVGPSRMSYQKVIPLLEYIAANLAKLYKDNNKET