ACL_RS02785

Uniprot: A9NFP3
Description: ribosomal RNA small subunit methyltransferase H 1
EC number: 2.1.1.199
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_01007}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_01007}.
Pathway:
Active site:
Binding site: BINDING 50 50 S-adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_01007}.; BINDING 76 76 S-adenosyl-L-methionine; via amide nitrogen. {ECO:0000255|HAMAP-Rule:MF_01007}.; BINDING 97 97 S-adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_01007}.; BINDING 104 104 S-adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_01007}.
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rsmH1
Gene names (synonym): mraW1
Mass: 34,090
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]; rRNA base methylation [GO:0070475]
Gene ontology IDs: GO:0005737; GO:0070475; GO:0071424
Chain: CHAIN 1 299 Ribosomal RNA small subunit methyltransferase H 1. /FTId=PRO_0000386678.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the methyltransferase superfamily. RsmH family. {ECO:0000255|HAMAP-Rule:MF_01007}.
Protein families: Methyltransferase superfamily, RsmH family
Coiled coil:
Domain [FT]:
Motif:
Region: REGION 31 33 S-adenosyl-L-methionine binding. {ECO:0000255|HAMAP-Rule:MF_01007}.
EMBL: CP000896
ProteinModelPortal: A9NFP3
MEROPS:
EnsemblBacteria KO: ABX81173
UniPathway: K03438
CDD:
Gene3D:
HAMAP: 1.10.150.170;3.40.50.150
InterPro: MF_01007
PANTHER: IPR002903;IPR023397;IPR029063
PIRSF: PTHR11265
PRINTS: PIRSF004486
PROSITE:
Pfam:
ProDom: PF01795
SMART:
SUPFAM:
TIGRFAMs: SSF53335;SSF81799

590535-591435(+)

>nucleotide sequence
ATGAAACATATCAGTGTATTATTAAATGAATCGATAGAAGGTCTAAACATCAAACCAAAC
GGTATCTATGTAGATGCTACTTTAGGTGGTGGTGGACACTCCCTAGAAATATTAAAAAAA
CTTGATAAAGGGCACTTATATGCTTTTGATCAAGATGCTTATGCAATTGGTAGAGCAACC
GAAAGATTAAAAGACTTTAGCAATAAAACATTTATTCAATCAAATTTTTCATTTATAAAA
GAAAAATTAAATGAACTGGGCATATATCAAGTAGATGGTATTATTTTTGACCTTGGTTTA
TCCTCATTTCAAATTGATGATGAAACTAGAGGGTTTTCATATCTTAAAGACTATGATTTA
GACATGCGTATGAACAAGGATGCAACCCTAACAGCTAAAGAAATCGTAAACACTTATGAA
AGACAAAAACTAGCAGATATCTTTAGAGCTTATGGTGATGAAGAAAATGCCTGGAAAATT
GCAGGCATGATTGTAGATAGAAGACCACTAAACACAACATTAGAATTAGTTGAGATAACA
GATATTGCTAATAAAGGCATGAAAGGGCACTCTGCTAAGCGTGTTTTCCAGGCTTTGAGA
ATCGAGGTCAACAAGGAGTTAGAAGTACTTGAAAGAGCCTTGAATAGCGCCTTAGAACTC
CTTAATATCGGTGGTAGATTATCCATCATTACCTTCCAATCACTAGAAGATAAAATGGTA
AAATCTTTTTATAAAACACATAGTCAAATGGATTACCCTAAAAACATAGATATTAGAACA
TTTCCAAAGCCACCTTTAAAAATTATTACAAGAAAACCGGTACTACCTTCAGAAATAGAA
CTAGAACATAATTCTAGAAGTCGTTCTGCTAAATTAAGAATCGCTGAAAAGCAAAGCTAA

>protein sequence
MKHISVLLNESIEGLNIKPNGIYVDATLGGGGHSLEILKKLDKGHLYAFDQDAYAIGRAT
ERLKDFSNKTFIQSNFSFIKEKLNELGIYQVDGIIFDLGLSSFQIDDETRGFSYLKDYDL
DMRMNKDATLTAKEIVNTYERQKLADIFRAYGDEENAWKIAGMIVDRRPLNTTLELVEIT
DIANKGMKGHSAKRVFQALRIEVNKELEVLERALNSALELLNIGGRLSIITFQSLEDKMV
KSFYKTHSQMDYPKNIDIRTFPKPPLKIITRKPVLPSEIELEHNSRSRSAKLRIAEKQS