ACL_RS02795

Uniprot: A9NFP5
Description: nicotinate-nicotinamide nucleotide adenylyltransferase
EC number: 2.7.7.18
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+). {ECO:0000255|HAMAP-Rule:MF_00244}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). {ECO:0000255|HAMAP-Rule:MF_00244}.
Pathway: PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00244}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): nadD
Gene names (synonym):
Mass: 22,397
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; NAD biosynthetic process [GO:0009435]
Gene ontology IDs: GO:0004515; GO:0005524; GO:0009435
Chain: CHAIN 1 188 Probable nicotinate-nucleotide adenylyltransferase. /FTId=PRO_0000336674.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the NadD family. {ECO:0000255|HAMAP-Rule:MF_00244}.
Protein families: NadD family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFP5
MEROPS:
EnsemblBacteria KO: ABX81175
UniPathway: K00969
CDD:
Gene3D:
HAMAP: 3.40.50.620
InterPro: MF_00244
PANTHER: IPR004821;IPR005248;IPR014729
PIRSF: PTHR12039
PRINTS:
PROSITE:
Pfam:
ProDom: PF01467
SMART:
SUPFAM:
TIGRFAMs:

592805-593372(+)

>nucleotide sequence
ATGGTACTTGTCTATGGGGGAAGCTTTAACCCACCAACCATTGCTCATGAAGCAATTATA
CATAAATTACATGAAGAATTCAAACCTAAAAAAATCTTAATTGTCCCAACAGGCAATTAT
TTTAGTTGGAAGACGGACCTAATTGACTTCGAACATCGTTTCAAGATGGTTGAACTTATG
ACGCAACATTTAGATTATGTCGAAATCAGTAGACTAGAAAATACGAAAGCATTTTTAGGT
TCCTATCATACCTTGAATGAACTAAGTAAACGCTATGATGATTTGTATTTTGTAGTAGGT
GCAGACCATATAAAGACTTTAGATCAATGGAAAGATTATAAAAAGTTGATTGAAAACTAT
AAATTTATCTTGCTTACTAGAAATAACTATACTTTTGATGATGATTTACTCAGTAAGCTT
GGTTTAAAGTATGAAAAAATGATGTTTCAAAGTGATATAAGTAGTTCTGAAATTAGAAAA
AACTTAAATCAAAATTTAGACAAATTAAACTTAAATGTAAAAACATATATTTTAGAAAAT
AAACTCTATGAAGAGGTGAAAGTATGA

>protein sequence
MVLVYGGSFNPPTIAHEAIIHKLHEEFKPKKILIVPTGNYFSWKTDLIDFEHRFKMVELM
TQHLDYVEISRLENTKAFLGSYHTLNELSKRYDDLYFVVGADHIKTLDQWKDYKKLIENY
KFILLTRNNYTFDDDLLSKLGLKYEKMMFQSDISSSEIRKNLNQNLDKLNLNVKTYILEN
KLYEEVKVW