ACL_RS02810

Uniprot: A9NFP8
Description: ATP-dependent exoDNAse (exonuclease V) subunit alpha
EC number: 3.6.4.12
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. {ECO:0000256|HAMAP-Rule:MF_01488}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-Rule:MF_01488}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 340 344 ATP. {ECO:0000256|HAMAP-Rule:MF_01488}.
Site:
Gene names (primary): recD
Gene names (synonym): recD2
Mass: 85,429
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; ATP-dependent 5'-3' DNA helicase activity [GO:0043141]; DNA binding [GO:0003677]; exonuclease activity [GO:0004527]
Gene ontology IDs: GO:0003677; GO:0004527; GO:0005524; GO:0043141
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the RecD family. RecD-like subfamily. {ECO:0000256|HAMAP-Rule:MF_01488}.
Protein families: RecD family, RecD-like subfamily
Coiled coil:
Domain [FT]: DOMAIN 329 486 AAA. {ECO:0000259|SMART:SM00382}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NFP8
MEROPS:
EnsemblBacteria KO: ABX81178
UniPathway: K03581
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_01488
PANTHER: IPR003593;IPR006345;IPR027417;IPR029493;IPR027785
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF14490;PF13538
SMART:
SUPFAM: SM00382
TIGRFAMs: SSF52540

596353-598603(+)

>nucleotide sequence
ATGGAAATTAAAGTAAGAGGATTCATCAAATCCTATGTTTTTAAAAATGAATCTAATGGC
TATACGATTGCTAAACTAGAAACCAATGATAAAGAGTTAATCTCTATTGTTGGTTATTTT
CCTTTATTAAGTGAAGAATTAGAATACGAGTTTACTGGTGAAGAGACCATACACCCTAAA
TTTGGGCGTCAACTGACAGTTAAAAGTTATGAAAGATTAGAAAACACTTCAGAATCAGGT
TTAGTCAGATACTTATCCAGTGATAATTTTTCTGGTATTGGACCGGTTACAGCTGAAAAA
ATAGTCAGTTTATTAGGCACAGATGCCATAGAAAAAATAATCACTGATGAAAATGTATTA
AGTCCAATTTTAAATCCAATCAAGCGAAATAGACTCAAAAAAGAATTAATTAGTCACCAA
GCTGAACAACGTATTTTTGTTAAACTTTTAGATTTAGGTCTAACTACCCGTATATCTGCT
AAATTGTTTAGCAATTATGGCAGTCAAACCTTAGAAAAGTTAGAAGAAGATCCTTATCGA
CTGATGTATGAAATTGATGGATTTGGGTTTATAAAATCAAGAGATATCGCTGAAAAATTT
GGTATTTCAAAAACGGATATTAGAACTTTAAAAGCTGCATTAGTTTATGCACTCATAACT
ACATCTAATAGTGAGGGTAACCTCTACTTATTTGAAGAAGAACTGATGAGTAGAGTATCT
AGAGTCATTGATGTAGATGCTGATTTTAAACCAGCGATTGATGAACTCATTAAAGAAAAT
AAATTAGTATTAGAAGATGATAAGTACTTCTTAAAACAAATCTATAGAGATGAAATTGAT
ATTGCAAAACGCATTAAAGAGTTAAAAACATATCCACTTGATCATGTGGATACTGAACTA
TTAGAGTTGATGTTATCTCAGATCTCTATACAAAAATCTATTGATTATACAGAAAAACAA
AGACAAGCTATTATTACAGCAATGCAAAATCCACTCACTGTTATTACTGGTGGACCAGGT
ACTGGTAAAACGACCTTAATTGATGGGTTCTTAGAGTTATATGCTAAATATTTTAAAATT
AACTTAAAATCTAAAGATGCAACCAATGAGATTGCACTTATGGCACCAACAGGACGTGCA
TCTAAACGTATGAGAGAATTACTTGATTTTCCTGCACGTACGATTCACTCACATTTAGGA
TTTGATTTTGATCAGTCATTTAAGTCCAATAAAGTTCAACCACTGGTTCAAAATCTTATT
ATCATCGATGAAGCATCGATGATAGATATCTACTTAATGAAAAGACTCCTAAATAGCATT
ATAGATGGTACTAGAGTCGTTATTGTGGGTGATGAAGATCAACTACCAAGTGTTGGTCCG
GGCTACGTTTTAGGTGATTTAATTAGTTCTAATGTTGTACCAGTGATAAGACTTAATGAA
ATACATAGACAAGCTAAGGATTCTCATATTGTAAAACTAGCATCCTCTATTAATAATCAA
AATTTAAGTCAAGAAGATTTAATTAGTCATAATGACGTGACCTTTTATAGTGGTACTGGT
GAAGATATTAAAAGAGTAATCATTAATCAAATTGGTGGCGCCATGAAAAAAGGCTATGAT
TTAATTAATGACATTCAAGTTTTAATACCTCAATATAAAGGTGACTTAGGTATTGATACA
ATGAACTTAGAAATACAAGCTAAGTTTAATCCAAATTATAATCAACCACCATTTATGAAG
TTTGGCGATAAAACCTACTACATAGGTGATAAAGTCATCCAACTTCAAAATGATAAAGAC
AAAGAAATCATGAATGGTGATATTGGTGTAGTTAAAGCGATACGTAAAAACGATAAAAAT
CAAAAGATTTTACAAGTAGATTTTGATGGTTTATTAGTGAATTACGATCAAAATGAACTA
GATACCTTAAACCTCGCTTATGTCATTTCAATTCATAAGTCACAAGGTTCAGAATATCAA
GTAGTTTTCCTACCGATTATTAAAAGTTATTTACATATGCTAAAAAAAGAACTTATATAT
ACCGCGATTACACGTGCAAAATCACATCTATTAGTATTAGGAGATTTAAGATTACTTCAA
TACGCATCGAATCAGTTAGTTGAAAAAAGACATACGATGCTTAAAGAACGACTTACACAT
GATGAAGTATCATTCAACTTATTTGATCAATTAAGTGAAGAAGATGATTTAGATGAAACT
AAAGATTTAAGTCCATGGGACTTTATGTAG

>protein sequence
MEIKVRGFIKSYVFKNESNGYTIAKLETNDKELISIVGYFPLLSEELEYEFTGEETIHPK
FGRQLTVKSYERLENTSESGLVRYLSSDNFSGIGPVTAEKIVSLLGTDAIEKIITDENVL
SPILNPIKRNRLKKELISHQAEQRIFVKLLDLGLTTRISAKLFSNYGSQTLEKLEEDPYR
LMYEIDGFGFIKSRDIAEKFGISKTDIRTLKAALVYALITTSNSEGNLYLFEEELMSRVS
RVIDVDADFKPAIDELIKENKLVLEDDKYFLKQIYRDEIDIAKRIKELKTYPLDHVDTEL
LELMLSQISIQKSIDYTEKQRQAIITAMQNPLTVITGGPGTGKTTLIDGFLELYAKYFKI
NLKSKDATNEIALMAPTGRASKRMRELLDFPARTIHSHLGFDFDQSFKSNKVQPLVQNLI
IIDEASMIDIYLMKRLLNSIIDGTRVVIVGDEDQLPSVGPGYVLGDLISSNVVPVIRLNE
IHRQAKDSHIVKLASSINNQNLSQEDLISHNDVTFYSGTGEDIKRVIINQIGGAMKKGYD
LINDIQVLIPQYKGDLGIDTMNLEIQAKFNPNYNQPPFMKFGDKTYYIGDKVIQLQNDKD
KEIMNGDIGVVKAIRKNDKNQKILQVDFDGLLVNYDQNELDTLNLAYVISIHKSQGSEYQ
VVFLPIIKSYLHMLKKELIYTAITRAKSHLLVLGDLRLLQYASNQLVEKRHTMLKERLTH
DEVSFNLFDQLSEEDDLDETKDLSPWDFM