ACL_RS03385

Uniprot: A9NG16
Description: phosphopentomutase
EC number: 5.4.2.7
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate. {ECO:0000255|HAMAP-Rule:MF_00740}.; CATALYTIC ACTIVITY: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate. {ECO:0000255|HAMAP-Rule:MF_00740}.
Cofactor: COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-Rule:MF_00740}; ; Note=Binds 1 or 2 manganese ions. {ECO:0000255|HAMAP-Rule:MF_00740}
Enzyme regulation:
Function [CC]: FUNCTION: Phosphotransfer between the C1 and C5 carbon atoms of pentose. {ECO:0000255|HAMAP-Rule:MF_00740}.
Pathway: PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3. {ECO:0000255|HAMAP-Rule:MF_00740}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding: METAL 12 12 Manganese. {ECO:0000255|HAMAP-Rule:MF_00740}.; METAL 296 296 Manganese. {ECO:0000255|HAMAP-Rule:MF_00740}.; METAL 332 332 Manganese. {ECO:0000255|HAMAP-Rule:MF_00740}.; METAL 333 333 Manganese. {ECO:0000255|HAMAP-Rule:MF_00740}.; METAL 344 344 Manganese. {ECO:0000255|HAMAP-Rule:MF_00740}.
Nucleotide binding:
Site:
Gene names (primary): deoB
Gene names (synonym):
Mass: 44,505
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphopentomutase activity [GO:0008973]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; cellular metabolic compound salvage [GO:0043094]; deoxyribonucleotide catabolic process [GO:0009264]
Gene ontology IDs: GO:0000287; GO:0005737; GO:0006015; GO:0008973; GO:0009264; GO:0030145; GO:0043094
Chain: CHAIN 1 397 Phosphopentomutase. /FTId=PRO_1000133054.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the phosphopentomutase family. {ECO:0000255|HAMAP-Rule:MF_00740}.
Protein families: Phosphopentomutase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NG16
MEROPS:
EnsemblBacteria KO: ABX81296
UniPathway: K01839
CDD:
Gene3D:
HAMAP: 3.30.70.1250;3.40.720.10
InterPro: MF_00740
PANTHER: IPR017849;IPR017850;IPR010045;IPR006124;IPR024052
PIRSF:
PRINTS: PIRSF001491
PROSITE:
Pfam:
ProDom: PF01676
SMART:
SUPFAM:
TIGRFAMs: SSF143856;SSF53649

714149-715343(+)

>nucleotide sequence
ATGAGATTTAAAAGAGTATTTTTAATCGTCATGGACTCTTTAGGAGTCGGTGCATCAGAA
GATGCAAATCAATATTTTAATGAAGGGGTAGACGATACAAAAGCAAATACGTTTGGTCAT
ATTGCAGAAAGTATGGATCTTAGAATACCTAATTTAGAGAAGCTTGGTGTAGGTAATATC
ATACCTATAAAAGGTACTAAATCAGTTGAATTATCCTCATCTTATGTAACAAAAATTCGT
GAAAAATCACTAGGAAAAGATACGATGACAGGTCATTGGGAAATCATGGGCTTGTATGTT
ACAACACCATTTCAAACCTTTACAGACACTGGTTTTCCAAAAGAATTACTAGATGAATTA
GAAGAAAGAACCGGACGTAAAATCATCGGTAATATCGCAGCAAGTGGTACTGAAATATTA
AAGGATTTAGGTGAAGAACACATGAGGACTGGAGACTTAATTGTCTACACATCCGCAGAC
AGTGTACTTCAAATTGCGATGCATGAAGAGATCATTCCTATTGAAGAACAATACAGAATT
TCTGCAATTGCACGTGACATTACAATGAGACCAGACTGGAAAGTTGGACGTGTAATTACA
AGACCATTCTTAGGTACAAATAAGGACAACTTTAAGCGCACAAGTAATAGAAAAGATTAT
GCATTAAAACCAAGTGAAGAGACAACTTTAAACTTCCTAAGTGATGCTAATTATGATGTC
ATCGCACTAGGTAAAATCAATGATATTTTTGATGGTTACGGTATCAATAAATACAGTAAA
ACAGTATCGAATGATGATGGTATGAAACAGATTACAGAGTGGGCTAAAAAAGATTTTACA
GGATTATGTTTCTTAAATCTAGTAGACTTTGATGCACTCTACGGACACCGCAGAGACCCT
CATGGATATGGTAAAGCAATCATGGATATGGATAGTCAATTACCTGAATTAATGGCTAAT
TTAAATGAAGATGATTTACTCATTTTAACAGCTGATCATGGTAATGATCCAACCTATGTT
GGTACCGATCATACAAGAGAATTTGTACCAATGATAGCTTATAGCAAGTCATTTAAATCA
GGTGGTAGCCTACCAATACTTAATACATTTGCCGATTTAGGAAGTACAATTTCTGATAAC
TTTAAAGTCAAAAAAACAGAGCATGGTGACAGTTTCTTAAGTAAATTAAAATAA

>protein sequence
MRFKRVFLIVMDSLGVGASEDANQYFNEGVDDTKANTFGHIAESMDLRIPNLEKLGVGNI
IPIKGTKSVELSSSYVTKIREKSLGKDTMTGHWEIMGLYVTTPFQTFTDTGFPKELLDEL
EERTGRKIIGNIAASGTEILKDLGEEHMRTGDLIVYTSADSVLQIAMHEEIIPIEEQYRI
SAIARDITMRPDWKVGRVITRPFLGTNKDNFKRTSNRKDYALKPSEETTLNFLSDANYDV
IALGKINDIFDGYGINKYSKTVSNDDGMKQITEWAKKDFTGLCFLNLVDFDALYGHRRDP
HGYGKAIMDMDSQLPELMANLNEDDLLILTADHGNDPTYVGTDHTREFVPMIAYSKSFKS
GGSLPILNTFADLGSTISDNFKVKKTEHGDSFLSKLK