ACL_RS03480

Uniprot: A9NG35
Description: 2-deoxyribose-5-phosphate aldolase
EC number: 4.1.2.4
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. {ECO:0000255|HAMAP-Rule:MF_00114}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. {ECO:0000255|HAMAP-Rule:MF_00114}.
Pathway: PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. {ECO:0000255|HAMAP-Rule:MF_00114}.
Active site: ACT_SITE 151 151 Schiff-base intermediate with acetaldehyde. {ECO:0000255|HAMAP-Rule:MF_00114}.; ACT_SITE 180 180 {ECO:0000255|HAMAP-Rule:MF_00114}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): deoC
Gene names (synonym):
Mass: 23,781
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; deoxyribose-phosphate aldolase activity [GO:0004139]; carbohydrate catabolic process [GO:0016052]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]
Gene ontology IDs: GO:0004139; GO:0005737; GO:0009264; GO:0016052; GO:0046386
Chain: CHAIN 1 222 Deoxyribose-phosphate aldolase. /FTId=PRO_1000076025.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. {ECO:0000255|HAMAP-Rule:MF_00114}.
Protein families: DeoC/FbaB aldolase family, DeoC type 1 subfamily
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NG35
MEROPS:
EnsemblBacteria KO: ABX81315
UniPathway: K01619
CDD:
Gene3D: cd00959
HAMAP: 3.20.20.70
InterPro: MF_00114
PANTHER: IPR013785;IPR011343;IPR002915;IPR028581
PIRSF: PTHR10889
PRINTS: PIRSF001357
PROSITE:
Pfam:
ProDom: PF01791
SMART:
SUPFAM: SM01133
TIGRFAMs:

730616-731285(-)

>nucleotide sequence
TCAATATGTGGTGTTGCCATCACTTGTTTCTCCTTTAATTAATTTGACTCCGCTAGATGT
ACCTAAGCGGTTAGCCCCTTTTTCTATCATTAATAATGCATCTTCTTTACTGCGGATACC
GCCACTTGCTTTAATCAGTGCGTCATCTCCTACAGCTTTTTTAATCGTAACGATATCTTC
AACAGATGCACCTCTTGATGCATAACCTGTAGATGTCTTAACGAATGTAGCTCCAGCTTT
AACAGCTAGTTTTGAAACAAATGTGATTTGTTTCTTATCAAGATAAGCTGTTTCAATAAT
CACTTTAACAGTTCTACCTTGAGCAGCCTTAACAACAGCTTTGATATCCTTAGATACACG
GCTACGATCTTTAGAACGTACTGCATCCACATCAACAACCATGTCAATTTCATCCGCACC
TTGTTTAATAGCTTCTTTTGTTTCAAAAGCTTTCACTTTTGGTAAGTGTGTTCCAAAAGG
AAAACCTACAACTGTACAAACTAATACACCTGTACCTTCTAGACGAGATTTAGCGTGTGC
AACCCAGATTGGTGAGACACAAACACTTTTAAACTGATGTTCAATTGCTTCATCAATAAG
TGTATCAATATCACTTAAAGTAACGATTGGACCAAGTTTAGTATGATCAATATATGTATT
TAATTTCAT

>protein sequence
MKLNTYIDHTKLGPIVTLSDIDTLIDEAIEHQFKSVCVSPIWVAHAKSRLEGTGVLVCTV
VGFPFGTHLPKVKAFETKEAIKQGADEIDMVVDVDAVRSKDRSRVSKDIKAVVKAAQGRT
VKVIIETAYLDKKQITFVSKLAVKAGATFVKTSTGYASRGASVEDIVTIKKAVGDDALIK
ASGGIRSKEDALLMIEKGANRLGTSSGVKLIKGETSDGNTTYW