ACL_RS03790

Uniprot: A9NG99
Description: diaminopimelate dehydrogenase
EC number: 1.4.1.16
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Meso-2,6-diaminoheptanedioate + H(2)O + NADP(+) = L-2-amino-6-oxoheptanedioate + NH(3) + NADPH. {ECO:0000256|PIRNR:PIRNR025648}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. {ECO:0000256|PIRNR:PIRNR025648}.
Pathway: PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1. {ECO:0000256|PIRNR:PIRNR025648}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 36,412
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR025648}.
Gene ontology (GO): diaminopimelate dehydrogenase activity [GO:0047850]; diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process via diaminopimelate [GO:0009089]
Gene ontology IDs: GO:0009089; GO:0019877; GO:0047850
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the diaminopimelate dehydrogenase family. {ECO:0000256|PIRNR:PIRNR025648}.
Protein families: Diaminopimelate dehydrogenase family
Coiled coil:
Domain [FT]: DOMAIN 5 70 F420_oxidored. {ECO:0000259|Pfam:PF03807}.; DOMAIN 123 278 DAPDH_C. {ECO:0000259|Pfam:PF16654}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NG99
MEROPS:
EnsemblBacteria KO: ABX81379
UniPathway: K03340
CDD:
Gene3D:
HAMAP: 3.40.50.720
InterPro:
PANTHER: IPR032094;IPR010190;IPR016040;IPR028939
PIRSF:
PRINTS: PIRSF025648
PROSITE:
Pfam:
ProDom: PF16654;PF03807
SMART:
SUPFAM:
TIGRFAMs: SSF51735

798885-799875(-)

>nucleotide sequence
TTAAATTAATTTCTTTCTAATTTCTTCAGCAGATAGATTTATTAAATAGGCTGGTGCAAT
ATCAGCAATTGTTTTAGCTCCACTTGCACCTTCTTTGTTTAGTCTATAAGCCGCTCTTGC
ATATGCCAGTAATACACGTGCTGTAAAATCCGGATTAGAGTCTAATTTAAGCTGGTATTG
AATCATTTGGTGATGTTCATTGTTTAAGCCTGTTTGACCGTATCTAATAACTAAGCCACC
ATGTGGTAAGCCTTGATGATTTTTTAGAAGTTCATCATGACTTATGAAATGCACTTTTGT
TTCATACGGTTCAAAATAATTAGGCATGGTCTTAATATCGTGTTCTATTTTTGTTAAGTC
TGCACCAGTTTCTGCAACAACATAACAAATTCTTTTATGCTTATCCTTTACAGATAGTGT
TGGCATGTCTCCATTTTTAACAGCATCAATTGCTGATTTAATCGGTACTGTATATTGAAC
AGCGTGTTTTACACCTGATACTCTTCTAATGGCATCTGAATGCCCTTGACTTACGCCTTC
TCCCCAAAAGGTATAGGTTTCACCAACTGGTAGTATAGCTTCAGCAAGTATTCTATTGAT
TGAAAACATACCAGGATCCCAACCACTTGCTACTACACTTAACTTTTGAGCCTTTTTAGA
TGCTTCATCCATATGGTTAAAATACTCATTTATTAAAGCATGGTTATCATATCCGTCTAC
AGTATTCATAAGACTTGCGATTAAAGGTCCTTGAACTGGTAAATCAGACATGCTACCACC
GCATAAAATAGCTACATCTATCCTATCTTTTAAGTTTTCGACTTCATCCAAATGATAAAC
TGATACACCTTTAGTCGTTGTCTCTAACGTTTTAGGATCACGTCTTGTAAATACACCAAA
CAGTTCCATATCATCACTTTGCAACAGACCAGTTTCTATGCTTTTACCAAGATTACCATA
TCCAATAATTGCAATTTTAATTTTACTCAT

>protein sequence
MSKIKIAIIGYGNLGKSIETGLLQSDDMELFGVFTRRDPKTLETTTKGVSVYHLDEVENL
KDRIDVAILCGGSMSDLPVQGPLIASLMNTVDGYDNHALINEYFNHMDEASKKAQKLSVV
ASGWDPGMFSINRILAEAILPVGETYTFWGEGVSQGHSDAIRRVSGVKHAVQYTVPIKSA
IDAVKNGDMPTLSVKDKHKRICYVVAETGADLTKIEHDIKTMPNYFEPYETKVHFISHDE
LLKNHQGLPHGGLVIRYGQTGLNNEHHQMIQYQLKLDSNPDFTARVLLAYARAAYRLNKE
GASGAKTIADIAPAYLINLSAEEIRKKLI