ACL_RS03860

Uniprot: A9NGB2
Description: tryptophan synthase subunit beta
EC number: 4.2.1.20
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O. {ECO:0000256|HAMAP-Rule:MF_00133, ECO:0000256|SAAS:SAAS00015899}.
Cofactor: COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000256|HAMAP-Rule:MF_00133, ECO:0000256|SAAS:SAAS00166768};
Enzyme regulation:
Function [CC]: FUNCTION: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. {ECO:0000256|HAMAP-Rule:MF_00133, ECO:0000256|SAAS:SAAS00541112}.
Pathway: PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. {ECO:0000256|HAMAP-Rule:MF_00133, ECO:0000256|SAAS:SAAS00015996}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): trpB
Gene names (synonym):
Mass: 42,603
Subunit structure [CC]: SUBUNIT: Tetramer of two alpha and two beta chains. {ECO:0000256|HAMAP-Rule:MF_00133, ECO:0000256|SAAS:SAAS00216216}.
Gene ontology (GO): tryptophan synthase activity [GO:0004834]
Gene ontology IDs: GO:0004834
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the TrpB family. {ECO:0000256|HAMAP-Rule:MF_00133, ECO:0000256|SAAS:SAAS00541094}.
Protein families: TrpB family
Coiled coil:
Domain [FT]: DOMAIN 46 372 PALP. {ECO:0000259|Pfam:PF00291}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGB2
MEROPS:
EnsemblBacteria KO: ABX81392
UniPathway: K01696
CDD:
Gene3D:
HAMAP:
InterPro: MF_00133
PANTHER: IPR006653;IPR006654;IPR023026;IPR001926
PIRSF: PTHR10314:SF3
PRINTS: PIRSF001413
PROSITE:
Pfam: PS00168
ProDom: PF00291
SMART:
SUPFAM:
TIGRFAMs: SSF53686

813254-814430(-)

>nucleotide sequence
TCAATCAACGATTTCAAAACCTCTAAACCTAGCAATATGCTTAACATCTTTATCGCCACG
ACCAGATAAGTTAACAACAATAATCTGATCCTTTGGTAAAGTTTTTGCAAGCGATATTGC
ATAGGCTAGAGCATGAGAGGATTCTATTGCAGGTATGATACCTTCTATAAGTGTTAAATA
CTCAAATGCTTGTACAGCTTCTTCATCTGTTGCACCAAAGTAAGTAACACGTTTAATTTC
ATCTAAATATGCATGTTCTGGACCAACACCAGGGTAGTCAAGTCCGGCAGAAATCGAGTA
TACTGGTGAAATTTCACCTTTATCATCCAATAAAACTTTAGTCTTCATTCCATGAATAAC
CCCAGTTTGACCAAGTGTCATCGTAGCAGCATGTAAATTTGTATCTAAACCTTTACCTAA
CGCTTCAACGCCAATAAGTTTTACAGTAGGATCCGGAATAAAATCAAAGAATGCACCAAT
TGCATTAGACCCGCCACCAACACAAGCAATGACATAATCTGGTAGTCTATTTTCTAATTT
TAGTATTTGTTCTTTAATCTCAATACCAATAACTTTTTGGAAATCACGAACCATCATCGG
ATATGGATGTGGTCCAACTGCTGAACCAATTAAGTAAAACATTGATTCATGTTCAGTACT
CCATTTTATTAAAGCACTATCAACAGCTTCTTTAAGTGTTCTTAATCCTTCTTGAACACT
AACTACAGTTGCACCTAAAAGTTGCATCTTATAAACATTAAGTGCTTGTTTTTCAACATC
TACTGCACCCATATGAATTTCACATTCTAAACCAAGTAGTGCTGCTACAGTTGCAGTGGC
TACACCATGTTGTCCAGCACCTGTTTCTGCAATCAACTTCTTTTTACCCATACGTTTAGC
AAGTAACGCTTGCCCAATGACATTATTAATTTTGTGAGAACCTGTATGATTTAAGTCTTC
ACGTTTTAAATATACTTTTGCACCACCAAGACATTCTGTTAAGCGTTTAGCAAAATACAA
ATTAGAAGGTCTACCAGCATATGTATTGAGTAAGTCTTTAAATTCTTCAATAAATGCAGG
ATCATCCTTGAATTTATTATATGCATCCTCTACTTCTTTAATTGCGGTAAGTAAGTACGG
TGGTAAGTATGCCCCACCAAATTGTCCAAATTCCAT

>protein sequence
MEFGQFGGAYLPPYLLTAIKEVEDAYNKFKDDPAFIEEFKDLLNTYAGRPSNLYFAKRLT
ECLGGAKVYLKREDLNHTGSHKINNVIGQALLAKRMGKKKLIAETGAGQHGVATATVAAL
LGLECEIHMGAVDVEKQALNVYKMQLLGATVVSVQEGLRTLKEAVDSALIKWSTEHESMF
YLIGSAVGPHPYPMMVRDFQKVIGIEIKEQILKLENRLPDYVIACVGGGSNAIGAFFDFI
PDPTVKLIGVEALGKGLDTNLHAATMTLGQTGVIHGMKTKVLLDDKGEISPVYSISAGLD
YPGVGPEHAYLDEIKRVTYFGATDEEAVQAFEYLTLIEGIIPAIESSHALAYAISLAKTL
PKDQIIVVNLSGRGDKDVKHIARFRGFEIVDW