ACL_RS03910

Uniprot: A9NGC3
Description: semialdehyde dehydrogenase
EC number: 1.2.1.11
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site: ACT_SITE 130 130 Acyl-thioester intermediate. {ECO:0000256|PIRSR:PIRSR000148-1}.; ACT_SITE 236 236 Proton acceptor. {ECO:0000256|PIRSR:PIRSR000148-1}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): asd
Gene names (synonym):
Mass: 36,435
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; aspartate-semialdehyde dehydrogenase activity [GO:0004073]; N-acetyl-gamma-glutamyl-phosphate reductase activity [GO:0003942]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; isoleucine biosynthetic process [GO:0009097]; lysine biosynthetic process via diaminopimelate [GO:0009089]; methionine biosynthetic process [GO:0009086]; threonine biosynthetic process [GO:0009088]
Gene ontology IDs: GO:0003942; GO:0004073; GO:0005737; GO:0009086; GO:0009088; GO:0009089; GO:0009097; GO:0050661; GO:0051287
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase family. {ECO:0000256|RuleBase:RU004041, ECO:0000256|SAAS:SAAS00558004}.
Protein families: Aspartate-semialdehyde dehydrogenase family
Coiled coil:
Domain [FT]: DOMAIN 5 121 Semialdhyde_dh. {ECO:0000259|SMART:SM00859}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGC3
MEROPS:
EnsemblBacteria KO: ABX81403
UniPathway: K00133
CDD:
Gene3D:
HAMAP: 3.40.50.720
InterPro:
PANTHER: IPR012080;IPR016040;IPR000534;IPR012280
PIRSF:
PRINTS: PIRSF000148
PROSITE:
Pfam:
ProDom: PF01118;PF02774
SMART:
SUPFAM: SM00859
TIGRFAMs: SSF51735

823606-824593(-)

>nucleotide sequence
TCATTTTATAAACTCCTTATAGATATACTCACCTATTTGTACTGCATTAAGTGCAGCACC
TTTTCTAACATTATCAGCTACTGTCCATAATAGTACTTTGTTTGGATAGTTTAAGTCTGT
TCTGATACGACCGATGTGAACTAAATTCGAGCCACTTGCATCTAAAGGTGTTGGATAATC
ATTGGATGGATATAACTTAACTTCGTCTATTTTTCCGTAAGCATTCTTTAGTTTATCCAA
GTCAATATTTTCTTTTGTGGTAGCTTTAATTTGGACACTATGTCCTACTTTTACTGGGAC
TCTGACTGTTGTTGCAGTTATGTTTATCTTTGAAGCTAATATTTTTTGAGTTTCTAAAAT
CATCTTCATTTCTTCTTTAGTATAACCATTTTCAAGAAATTGATCTATCTGAGGTATAAC
ATTATTATATATCGTTTTTGGATAAAAATTAGGTTCTAAGCCTTGTGATGTTCTCTCTAA
ATCCTCTATACCGTTAACCCCTGAACCACTGACTGCTTGATAGGTTGAATAGTCAACATC
TACTAAATTAAATAATTGATGTACTGTATGAAGTGCTACAACACTTTGTATGGTAGAGCA
ATTTGGATTTGCAACTATATAGTCACTAGATTTTAGCACATGACTATTCACCTCAGGTAC
AACTAATGGGATATGTTCTATCATGCGGTGCGCTGAGGAGTTATCTACAACATATATCTT
TTTAGAACTTGCGATTTTAGCGTATTTTAAAGCAAGGTCACTTTCTATTGCAAAAAACAC
GATATCTAAAGGATCATTAAAACTATCTTCGTTCAGTTCTTTGATAATGATAGTTTGACC
TTTAAATGCAACTTCTTTACCCTTAGAACGACTGGATGCGTATACATAAAGCGTATCTAC
CGGTAAGGATGATTGTTCAAGTATTTCTAGTAGAGTTTGACCAACCAAACCTGTAATACC
TACAATACCAACATTAACTTTTTTCAT

>protein sequence
MKKVNVGIVGITGLVGQTLLEILEQSSLPVDTLYVYASSRSKGKEVAFKGQTIIIKELNE
DSFNDPLDIVFFAIESDLALKYAKIASSKKIYVVDNSSAHRMIEHIPLVVPEVNSHVLKS
SDYIVANPNCSTIQSVVALHTVHQLFNLVDVDYSTYQAVSGSGVNGIEDLERTSQGLEPN
FYPKTIYNNVIPQIDQFLENGYTKEEMKMILETQKILASKINITATTVRVPVKVGHSVQI
KATTKENIDLDKLKNAYGKIDEVKLYPSNDYPTPLDASGSNLVHIGRIRTDLNYPNKVLL
WTVADNVRKGAALNAVQIGEYIYKEFIKW