ACL_RS03935

Uniprot: A9NGC8
Description: guanosine monophosphate reductase
EC number: 1.7.1.7
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH. {ECO:0000256|SAAS:SAAS00043006}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. {ECO:0000256|SAAS:SAAS00551747}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): guaC
Gene names (synonym):
Mass: 36,019
Subunit structure [CC]:
Gene ontology (GO): GMP reductase complex [GO:1902560]; GMP reductase activity [GO:0003920]; purine nucleotide metabolic process [GO:0006163]
Gene ontology IDs: GO:0003920; GO:0006163; GO:1902560
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. {ECO:0000256|SAAS:SAAS00569221}.
Protein families: IMPDH/GMPR family, GuaC type 2 subfamily
Coiled coil:
Domain [FT]: DOMAIN 5 311 IMPDH. {ECO:0000259|Pfam:PF00478}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGC8
MEROPS:
EnsemblBacteria KO: ABX81408
UniPathway: K00364
CDD:
Gene3D: cd00381
HAMAP: 3.20.20.70
InterPro: MF_01511
PANTHER: IPR013785;IPR005994;IPR015875;IPR001093
PIRSF:
PRINTS: PIRSF036500
PROSITE:
Pfam: PS00487
ProDom: PF00478
SMART:
SUPFAM:
TIGRFAMs:

830828-831806(-)

>nucleotide sequence
TTAAATCCAATCTCCATTAAAAATAGAGTTTTTAACAATTACATAGTCCACTTTTGTAAT
TGCCTCAATATCTTTACCACCTGCATAGGATATAGATGATTGTAAATCTTCTGTCATTTC
TTTTAAGGTATCTTCAATTTTACCTTTGTAAGAAATTAAGATGCGCTTACCTTCAACATT
GGTCTTTTCACCCTTTTGATACTCTGATGCGGAACCAAAATATTCTTTAAGTACTTGACC
ATCTGCTTCAATTGTTTGTCCAGGTGATTCTTCATGTCCTGCAAATAAAAAGCCAATCAT
AATCATGGATGCACCAAATCTAATAGATTTTGCAATGTCACCATGGGTACGAATGCCACC
ATCTGCGATCATTGGTTTTCTAGCAACTTTACTGCAACGAGAAAGTGCTGCGAGTTGCCA
TCCACCTGTACCAAAACCGGTTTTGATTTTAGTGATACAAACCTTACCTGGACCAACCCC
TACTTTTGTAGCATCTGCGCCTGCATTTTCAAGCTCTCTTACAGCTTCAGGAGTTGCAAC
ATTACCCGCAATTAAAAATGATGTAGGTAAATGTTTTTTAATATGAGTAATCATGTCAAT
GACTAGTTGACTATGACCATGAGCTATATCTATTGTAATATAGTCAGGAACTAAATTAAG
TCTTGAAAGTTCTTCAACAAAATCATATTCTTGTGGTTTCACACCAACAGAAATTGATGT
ATATAAGTTAAGTTCTTTCATCTTTATCATAAAAGGTATACGTGATGCTTCATCAAATCG
ATGCATGATATAAAAATAATCATGACTTGCTAACCAGATTGCTAACTTTTCATCAATAAT
GGTTGCCATGTTTGCTGGAACCACCGGAAGATTAAATCTTCTAGGTCCAAATTGAACAGA
TGTATCACATTCACTTCTAGATTTTACAATACTTTTAGAAGGAATAAGTTGAATATCTTC
GTAGTCAAAAACTTTCAT

>protein sequence
MKVFDYEDIQLIPSKSIVKSRSECDTSVQFGPRRFNLPVVPANMATIIDEKLAIWLASHD
YFYIMHRFDEASRIPFMIKMKELNLYTSISVGVKPQEYDFVEELSRLNLVPDYITIDIAH
GHSQLVIDMITHIKKHLPTSFLIAGNVATPEAVRELENAGADATKVGVGPGKVCITKIKT
GFGTGGWQLAALSRCSKVARKPMIADGGIRTHGDIAKSIRFGASMIMIGFLFAGHEESPG
QTIEADGQVLKEYFGSASEYQKGEKTNVEGKRILISYKGKIEDTLKEMTEDLQSSISYAG
GKDIEAITKVDYVIVKNSIFNGDWI