ACL_RS04015

Uniprot: A9NGE5
Description: bifunctional riboflavin kinase/FMN adenylyltransferase
EC number: 2.7.1.26; 2.7.7.2
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + FMN = diphosphate + FAD. {ECO:0000256|PIRNR:PIRNR004491}.; CATALYTIC ACTIVITY: ATP + riboflavin = ADP + FMN. {ECO:0000256|PIRNR:PIRNR004491}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. {ECO:0000256|PIRNR:PIRNR004491}.; PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. {ECO:0000256|PIRNR:PIRNR004491}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): ribF
Gene names (synonym):
Mass: 34,403
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; riboflavin kinase activity [GO:0008531]; FAD biosynthetic process [GO:0006747]; FMN biosynthetic process [GO:0009398]; riboflavin biosynthetic process [GO:0009231]
Gene ontology IDs: GO:0003919; GO:0005524; GO:0006747; GO:0008531; GO:0009231; GO:0009398
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ribF family. {ECO:0000256|PIRNR:PIRNR004491}.
Protein families: RibF family
Coiled coil:
Domain [FT]: DOMAIN 172 296 Flavokinase. {ECO:0000259|SMART:SM00904}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGE5
MEROPS:
EnsemblBacteria KO: ABX81425
UniPathway: K11753
CDD:
Gene3D:
HAMAP: 2.40.30.30;3.40.50.620
InterPro:
PANTHER: IPR004821;IPR015864;IPR023468;IPR002606;IPR015865;IPR023465;IPR014729
PIRSF: PTHR22749
PRINTS: PIRSF004491
PROSITE:
Pfam:
ProDom: PF06574;PF01687
SMART:
SUPFAM: SM00904
TIGRFAMs: SSF82114

847018-847912(-)

>nucleotide sequence
TTATTTTTTTAATAAGTTGTAAGTTTGTTCTACATCTTTTTTGATTTGTTCTAACATCGC
TTCTACTTTATCATATTTGATTTCATCTCTTAAATAATATTCAAATGAAACAGTAATTTC
TTTTTCATATAAATTACCATCATAATCCATGATAAACACTTCTAATCTTCTTGTTGTTGA
GTAGTTGATTGTTGGGTTATGACCTAAATTGGCGCATCCTAAATAGGTTTTATCACCTAT
TTCTACTATTACAGCATATACACCTATCTTAGGTAAAAAATGATTCTTATAGTCTATATT
AGCGGTTGGATACCCTATCATTTTACCAACCTTATCACCATGAATGACCTCACCATGGAT
GCTATAACTTTTATTAAGTAGTTTTCTAGCAAGTTTCATATCACCTTGCTCGAGTAATAA
CTTAATATAGGTTGTAGAAACACGTGTATCCTTATAAAGTAAATCTTCTACAACAAGTAC
TTCAAAATGTTGTTTTAAATCATCAACACTTCCAGATCCTTTATGACCAAACTTGAAATC
ACGACCGACAACAATACGTTTGACTTGAAGTGACTTTAACCATTCTATAAATTCTAGCTT
TTCTAATTTTGAGAATGCTTTTGTAAATTCAACAACCATAAATATATCAACATGCATCAT
TTTAAGTGCACGTTCTTTATCAGATATATCCATTAGAATGGGTAGTTCTTTATTGGTAAT
TACACTCATTGGATGAGGGAAAAATGTCATGACAGCACTTTTAGTGTCACTAAATTTTTT
CACCTTTTCAATAAGATTTTGATGTCCTATATGTAGCCCATCAAAATTACCAATGGTTAA
TGTAATGGGTTCATTATTTTTTATGGATTCATATGTAGTGTGTATTGTTTTCAT

>protein sequence
MKTIHTTYESIKNNEPITLTIGNFDGLHIGHQNLIEKVKKFSDTKSAVMTFFPHPMSVIT
NKELPILMDISDKERALKMMHVDIFMVVEFTKAFSKLEKLEFIEWLKSLQVKRIVVGRDF
KFGHKGSGSVDDLKQHFEVLVVEDLLYKDTRVSTTYIKLLLEQGDMKLARKLLNKSYSIH
GEVIHGDKVGKMIGYPTANIDYKNHFLPKIGVYAVIVEIGDKTYLGCANLGHNPTINYST
TRRLEVFIMDYDGNLYEKEITVSFEYYLRDEIKYDKVEAMLEQIKKDVEQTYNLLKK