ACL_RS04040

Uniprot: A9NGF1
Description: RNA pseudouridine synthase
EC number: 5.4.99.-
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: RNA uridine = RNA pseudouridine. {ECO:0000256|RuleBase:RU362028}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Responsible for synthesis of pseudouridine from uracil. {ECO:0000256|RuleBase:RU362028}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rluA2
Gene names (synonym):
Mass: 33,419
Subunit structure [CC]:
Gene ontology (GO): pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; pseudouridine synthesis [GO:0001522]
Gene ontology IDs: GO:0001522; GO:0003723; GO:0009982
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the pseudouridine synthase RluA family. {ECO:0000256|RuleBase:RU362028}.
Protein families: Pseudouridine synthase RluA family
Coiled coil:
Domain [FT]: DOMAIN 11 79 S4 RNA-binding. {ECO:0000259|PROSITE:PS50889}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGF1
MEROPS:
EnsemblBacteria KO: ABX81431
UniPathway: K06180
CDD:
Gene3D:
HAMAP: 3.10.290.10
InterPro:
PANTHER: IPR020103;IPR006225;IPR006224;IPR006145;IPR002942
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01129;PS50889
ProDom: PF00849;PF01479
SMART:
SUPFAM: SM00363
TIGRFAMs: SSF55120

852428-853322(-)

>nucleotide sequence
TTAACCTAAGGTAACTAGATAACTTTCAAATTCAGGTGGTAATGGTGCTTCAAGCATCAT
TACTTTTTTTGTTATTGGATGCACAAATTCTAATCTAAATGCATGTAATAACTGACCATC
TTTTAATATTTTAGCTTTTGTACCATATAACGGATCTCCAGTAACTGGATGTTTAATATA
TGCTAAATGAACACGTATTTGATGTGTTCTACCTGTTTCTAATTTACAATGAAGTAATGT
ATGATCTCTAAATGTTCTCATCACTTCAAAGTGTGTAATTGCTGGTTTACCTGTTGCTAC
AACAGCCATTTTTGTACGAATTTTGGGATGTCTTGCAATTGGTGCATCAATCACACCTTT
ATTATGATCTAAAACACCTTCAACAAGTGCAATATATTCACGTTTGATGTCATGTGATTT
TAAATCTTGGGCTAATATTTTGTGTGCTTCGTTAGTTTTAGCAACCAATATAAGGCCTGA
TGTATCTTTATCAATGCGATGTAGGATACCTGGTCTTAAAGGGTCATCATTGTGTGTAGA
TAGTGTATCTGTGTGGTGTAACAAACCAGACACTAAGGTTGTTTCACTAAAGGTTTCAGA
AGGGTGAACCACCAATCCTTTAGGTTTATTAATAACCATAATATCATCATCTTCATAAAC
GATATTTAAATCGATATTTTTAGGTTTTAGTGGATTTGTTTCTTCTTTAGCCTCAAGGTT
TAGAGTAATTTCATCACTATTTTTCAGCTTATAACCAGCTTTAGTAGTTAAACCATTAAC
CATGACAAGACCATCTTTGATAAGTGTAGTAATTTGACTTCTATTAAGCTCAGTTGATGC
TACTAAGAAGTGGTCAAGACGACTATCTGTTTGTTCTGTAATTTTAAATTTCAT

>protein sequence
MKFKITEQTDSRLDHFLVASTELNRSQITTLIKDGLVMVNGLTTKAGYKLKNSDEITLNL
EAKEETNPLKPKNIDLNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLST
HNDDPLRPGILHRIDKDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKG
VIDAPIARHPKIRTKMAVVATGKPAITHFEVMRTFRDHTLLHCKLETGRTHQIRVHLAYI
KHPVTGDPLYGTKAKILKDGQLLHAFRLEFVHPITKKVMMLEAPLPPEFESYLVTLG