ACL_RS04095

Uniprot: A9NGG2
Description: guanosine polyphosphate pyrophosphohydrolase
EC number: 3.1.7.2
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. {ECO:0000256|RuleBase:RU003847}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): spoT
Gene names (synonym):
Mass: 82,572
Subunit structure [CC]:
Gene ontology (GO): amino acid binding [GO:0016597]; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; guanosine tetraphosphate metabolic process [GO:0015969]
Gene ontology IDs: GO:0008893; GO:0015969; GO:0016597
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the relA/spoT family. {ECO:0000256|RuleBase:RU003847}.
Protein families: RelA/spoT family
Coiled coil:
Domain [FT]: DOMAIN 45 155 HDc. {ECO:0000259|SMART:SM00471}.; DOMAIN 238 348 RelA_SpoT. {ECO:0000259|SMART:SM00954}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGG2
MEROPS:
EnsemblBacteria KO: ABX81442
UniPathway: K00951
CDD:
Gene3D: cd01668
HAMAP: 3.10.20.30
InterPro:
PANTHER: IPR002912;IPR012675;IPR003607;IPR004811;IPR007685;IPR004095;IPR012676;IPR033655
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF13291;PF13328;PF04607;PF02824
SMART:
SUPFAM: SM00471;SM00954
TIGRFAMs: SSF81271

861407-863582(-)

>nucleotide sequence
TCATATAATTTCACGCTCTACATAATATACTTGAGGTACTTTTTGAATGTTTAGGATTAA
TAAATCAAGTTCTCTTTTTTCTTTTAAAGTCACTTTTAATTTAATAATGCTTTCAAGTTC
ATGACTAGTAATTGCAGAAACTTCAGCAATTGCTATACCACTTGAATTTGCAGTCTGAAT
AATTTCAGTTAATAAACCATTTCTCGTTGTACCTTTAATTTTGATCCAAGTTGCATATTT
TCTATTAATATTTGTACCCCAATATGCTGGAATTAATCGGTTTTTATCATATTGTTGTAA
GTTGATACAGTGTTGTGCATGGACAACAATACCGCTACCCTTTGTAACATAACCAGAGAT
AGAATCACCCGGGATTGGTGTACAACAGTTAGCAAGTTTTATTTGTGGTGTTGTTAAACC
TTCTATAATTACACCCGTATCTGATGTTGCTGTTAATTGTCTTTGTGTACGTTCTATTTG
ACGCTGAATCAATTGTTCTTTTGATATTTCAGGCATCAATTTATTAAGAACTGTTTTTGT
AGATACATTACCTTTACCAATTTCAAGGTATAAATCTTGTAAATTGGTAATGGATATTTT
CTCAAAGTTTTGACGTACCCATTCATCAGTAATTACATCTTCTTTTTTATTCATTAACAA
CTCTTTATCAAGTAGTTCTTTACCATTTGCTAATGTGTATTCATAATTACTCTTATTAAT
GAAACCTTTAATCTTATGTCTAGCATGTGCCGATTTGGCTATTTTAAGCCAATCTTCACT
TGGTCCAGATGAATTTTTGTTTGTCTTAATTGCAACAACATCACCTGTTTGAAGTTCATA
GTCTAGTGTTACAATACGGTTATTTACTGTTGCACCAACCATTTTATGACCTACATCAGT
GTGGATTTTATAAGCAAAGTCAATCGGTGTTCCACCACTAGGGATTTCAACGACTTCACC
TTTAGGTGTAAAGACATAGACGTTTGCAGAAAATATATCAGTTTTAACAGTTTCAACAAA
CTCTTCTGAGTTTTCACCTTGATCATCTTTATCCTCAGTCATACGCAATAGATCGGCATA
CCATTTAAGGCGTGACATCATTTCAAATTGTTCTTTTTCTTTGGAATAAACCTTATTTTC
TTTATATGCCCAGTGAGCAGCAATACCATCTTCAGCTACTTTATCCATCTCTTTTGTACG
TATTTGAACCTCAAATAACGTACCATCTGAATGAAGTACGGTTGTATGAAGTGATTGATA
AAGGTTTGGTTTAGGTACAGCAATATAATCTTTAAATCTTTTAGGGATTGGTGTAAAGTG
AGCATGGATAATACCTAAGGATTGGTAACATGTCTCAACTTTATCAACGATAATTCGAAC
TGCTAAAAGATCATAAATATCTTCAAAATCTCTCATATCTTTAGTCATCTTTTTATAGAT
GGAATAGATATTTTTAATTCTACCTTTAATTTCAAAATTAGTTAAATCAGATTCTTTAAA
TAATTCTTTAATGTAGTCAATGACGTTATTAATATTACTTTCACGTTCTACTTTTTTAGC
TTTGACTAAATTAGATACCTTATAGTACATCGCAGGATGTACATAACGTAATGCCCTATC
TTCTAATTCTGCTTTCCATCTAAAAAGACCGAGTCTGTGAGCAATCGGTGCATATATATC
TAAAGTTTCTTTTGAAATAGCTATTTGTCTATCCGGAGCCATAGAATCCAGTGTTCTCAT
ATTTTGAAGTCTATCCGCGATTTTTATTAAGATGACTCGGATATCTTTAGCCATAGCTAA
AAGCATTTTTTGTTGATTATCTGTTTGTAATGAATTTTTGAATTGAAGTTTACTTAACTT
AGTAACAGCATCTACTAGTGATGCAACATCTTTACCAAAGTCTTTTTCAATACCTTCAAG
TGTATAATCAGTATCTTCTACCGTATCATGTAGTAGTGCTGCTACTAATGTTTGTGGACC
AGCTTCTAGTTCTGCTAAAATTCTAGCTACTGCAGTAGGGTGGGTAATATAAGGTTCCCC
ACTCTTACGCATTTGACCTAAATGTTTCTCTTTAGCTACAATATAAGCTTTTGTGATTAA
ATTGATATTTGATTCACTTTTAATATAGTGTGAGATATCCTTGATTAATGCTTTATATAG
TGCATCGTTCATCAT

>protein sequence
MMNDALYKALIKDISHYIKSESNINLITKAYIVAKEKHLGQMRKSGEPYITHPTAVARIL
AELEAGPQTLVAALLHDTVEDTDYTLEGIEKDFGKDVASLVDAVTKLSKLQFKNSLQTDN
QQKMLLAMAKDIRVILIKIADRLQNMRTLDSMAPDRQIAISKETLDIYAPIAHRLGLFRW
KAELEDRALRYVHPAMYYKVSNLVKAKKVERESNINNVIDYIKELFKESDLTNFEIKGRI
KNIYSIYKKMTKDMRDFEDIYDLLAVRIIVDKVETCYQSLGIIHAHFTPIPKRFKDYIAV
PKPNLYQSLHTTVLHSDGTLFEVQIRTKEMDKVAEDGIAAHWAYKENKVYSKEKEQFEMM
SRLKWYADLLRMTEDKDDQGENSEEFVETVKTDIFSANVYVFTPKGEVVEIPSGGTPIDF
AYKIHTDVGHKMVGATVNNRIVTLDYELQTGDVVAIKTNKNSSGPSEDWLKIAKSAHARH
KIKGFINKSNYEYTLANGKELLDKELLMNKKEDVITDEWVRQNFEKISITNLQDLYLEIG
KGNVSTKTVLNKLMPEISKEQLIQRQIERTQRQLTATSDTGVIIEGLTTPQIKLANCCTP
IPGDSISGYVTKGSGIVVHAQHCINLQQYDKNRLIPAYWGTNINRKYATWIKIKGTTRNG
LLTEIIQTANSSGIAIAEVSAITSHELESIIKLKVTLKEKRELDLLILNIQKVPQVYYVE
REIIW