ACL_RS04100

Uniprot: A9NGG3
Description: adenine phosphoribosyltransferase
EC number: 2.4.2.7
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. {ECO:0000255|HAMAP-Rule:MF_00004}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. {ECO:0000255|HAMAP-Rule:MF_00004}.
Pathway: PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00004}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): apt
Gene names (synonym):
Mass: 18,484
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00004}.
Gene ontology (GO): cytoplasm [GO:0005737]; adenine phosphoribosyltransferase activity [GO:0003999]; adenine salvage [GO:0006168]; AMP salvage [GO:0044209]
Gene ontology IDs: GO:0003999; GO:0005737; GO:0006168; GO:0044209
Chain: CHAIN 1 170 Adenine phosphoribosyltransferase. /FTId=PRO_0000329335.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase family. {ECO:0000255|HAMAP-Rule:MF_00004}.
Protein families: Purine/pyrimidine phosphoribosyltransferase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGG3
MEROPS:
EnsemblBacteria KO: ABX81443
UniPathway: K00759
CDD:
Gene3D: cd06223
HAMAP: 3.40.50.2020
InterPro: MF_00004
PANTHER: IPR005764;IPR000836;IPR029057
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00103
ProDom: PF00156
SMART:
SUPFAM:
TIGRFAMs: SSF53271

863601-864114(-)

>nucleotide sequence
TTAGTAGTTAATAAGTGTCTTTACATCGTAATTTTTAAGTAATTTTCTTCCTTCTAAATC
ATCCAACTCGATTAAGAACGCAAGACCTACAACAATACCACCTAATTTTTCAACCAATTC
TACTGTTGCTTGCATTGTACCACCTGTTGCCAATAAATCGTCAATAATAACAACTCTTTG
TCCAGGTTTTACTGCATCTTCATGTAAAGATAATGAGTTAGAGCCATATTCTAAATCGTA
ACTCACTGTAACTGATGCTCTAGGTAATTTACCAGGTTTTCTAACTGGTGCAAATCCAAC
ACCTAAATTAACTGCTACAGGACAACCAAAAATAAATCCTCTTGCTTCAGGACCTACGAT
TAAATCTGCTTTTTTTGATCTTGCAAACTCGGTAAATTGATCAGATGCATACTTAAATGC
TTTACCATCTAACATCAGAGGTGTAATATCTCTAAATAGGATACCTTCTTTAGGAAAATC
TTTTACTGCTGCAATATGTGCTTTTAAATCCAT

>protein sequence
MDLKAHIAAVKDFPKEGILFRDITPLMLDGKAFKYASDQFTEFARSKKADLIVGPEARGF
IFGCPVAVNLGVGFAPVRKPGKLPRASVTVSYDLEYGSNSLSLHEDAVKPGQRVVIIDDL
LATGGTMQATVELVEKLGGIVVGLAFLIELDDLEGRKLLKNYDVKTLINY