ACL_RS04455

Uniprot: A9NGN4
Description: transcription elongation factor GreA
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. {ECO:0000255|HAMAP-Rule:MF_00105}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): greA
Gene names (synonym):
Mass: 17,726
Subunit structure [CC]:
Gene ontology (GO): DNA binding [GO:0003677]; regulation of DNA-templated transcription, elongation [GO:0032784]; transcription, DNA-templated [GO:0006351]
Gene ontology IDs: GO:0003677; GO:0006351; GO:0032784
Chain: CHAIN 1 158 Transcription elongation factor GreA. /FTId=PRO_1000094145.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000255|HAMAP-Rule:MF_00105}.
Protein families: GreA/GreB family
Coiled coil: COILED 14 76 {ECO:0000255|HAMAP-Rule:MF_00105}.
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGN4
MEROPS:
EnsemblBacteria KO: ABX81514
UniPathway: K03624
CDD:
Gene3D:
HAMAP: 1.10.287.180;3.10.50.30
InterPro: MF_00105
PANTHER: IPR018151;IPR006359;IPR028624;IPR001437;IPR023459;IPR022691
PIRSF:
PRINTS: PIRSF006092
PROSITE:
Pfam: PS00829
ProDom: PF01272;PF03449
SMART:
SUPFAM:
TIGRFAMs: SSF46557

932603-933080(-)

>nucleotide sequence
TTAACTAATTGCTTTAATCTCTACGTTTGATTGTTTATTTGTTGCAGATTTGATTTGTAC
TAAATCTCCAACTTCTTTACCCTTGATAGCACGTCCTAATGGAGATTCGATAGAAATCTT
GAAATTCTTAGGGTCTGCTTCAATGGTTCCAACAACATGGTACTCAACATCTTTGTTCTT
TTCTACAAAGTGAAGTAATACTTTTTTACCAATATTTACAGTTGTTGAATCATCATTAGT
TCTAATTATTTTTACATTTTTTAAGATGCTTTCAATTTCAAGAATTCGTGCTTCAATTCT
AGCTTGTTCATTACGAGCTGCATCATAGTCAGCATTTTCTGATAAGTCACCTTGTTCACG
AGCTTCTTTTAAAGCCTCTAAGTTTTCAACACGTTTAACATCTTTTAAATGTGTTAATTC
ATCTTTTAGTTGATCTAAACCCGATTGGGTAAGTTCATATACTTTTTTACTTGCCAT

>protein sequence
MASKKVYELTQSGLDQLKDELTHLKDVKRVENLEALKEAREQGDLSENADYDAARNEQAR
IEARILEIESILKNVKIIRTNDDSTTVNIGKKVLLHFVEKNKDVEYHVVGTIEADPKNFK
ISIESPLGRAIKGKEVGDLVQIKSATNKQSNVEIKAIS