ACL_RS04520

Uniprot: A9NGP8
Description: ribosomal RNA small subunit methyltransferase H 2
EC number: 2.1.1.199
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_01007}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_01007}.
Pathway:
Active site:
Binding site: BINDING 98 98 S-adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_01007}.; BINDING 131 131 S-adenosyl-L-methionine; via amide nitrogen. {ECO:0000255|HAMAP-Rule:MF_01007}.; BINDING 145 145 S-adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_01007}.; BINDING 152 152 S-adenosyl-L-methionine. {ECO:0000255|HAMAP-Rule:MF_01007}.
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rsmH2
Gene names (synonym): mraW2
Mass: 39,450
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]; rRNA base methylation [GO:0070475]
Gene ontology IDs: GO:0005737; GO:0070475; GO:0071424
Chain: CHAIN 1 344 Ribosomal RNA small subunit methyltransferase H 2. /FTId=PRO_0000386679.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the methyltransferase superfamily. RsmH family. {ECO:0000255|HAMAP-Rule:MF_01007}.
Protein families: Methyltransferase superfamily, RsmH family
Coiled coil:
Domain [FT]:
Motif:
Region: REGION 78 80 S-adenosyl-L-methionine binding. {ECO:0000255|HAMAP-Rule:MF_01007}.
EMBL: CP000896
ProteinModelPortal: A9NGP8
MEROPS:
EnsemblBacteria KO: ABX81528
UniPathway: K03438
CDD:
Gene3D:
HAMAP: 1.10.150.170;3.40.50.150
InterPro: MF_01007
PANTHER: IPR002903;IPR023397;IPR029063
PIRSF: PTHR11265
PRINTS: PIRSF004486
PROSITE:
Pfam:
ProDom: PF01795
SMART:
SUPFAM:
TIGRFAMs: SSF53335;SSF81799

945046-946081(-)

>nucleotide sequence
TTAACCTTTAATAGCAATCCTTAGTTTTGCAGATCTTGCTCTTGGATTATTAAATACTTC
TTCTTTACTTGGTAATATCGGACCTTCTGTCATACTAAATACACCATCATTTAAATATTG
TTTAAATGCCTTTTTAACTAGCCTATCCTCACCGGAGTGAAATGATAAAATAGCCACTTT
ACCACCAGGATTTAATTTACCCGGTAATTTGTCAAGCATCTCAAATAACACTTCATACTC
ACTGTTAACATCAATTCTTAATGCTTGAAAAGTTCTACTCGATGCTTTTTTTAGTTCTTC
TTCATATACTTTTTTTGACACCTTTTGTAGTGCTGATGCAATGACCTGGTGTAAATCTAA
TGTCGTTCGGATGTACCTTCCTTGTATTTTCGCTTTTGTAATTTCTTTAGCTATTTCTTT
TGCATAAATTTCATCAGCGTTTTCAATTAACATATGCTCAATTTCTATTTCACTCATCTC
AAGTAATCTTACATATGCCGGAATACCAACATTTGGATTCATTCTTAGATCTAAAGGACC
TTCTTCTCTAAATGTAAAGCCTCTATCCGGATTATCAATTTGCATAGAAGAAACACCTAA
ATCCGCCAAAATAAAATCAAAGCCTTCAGTATCAATTGCATCAAAATCCTTGAAATTTAA
TTGATGAAGCGTAAAGTTATCTTTATTAAATCCGTAACTTTCTAGTCTAGCCCTTGTTTT
TGGTAGTTCAATAGGATCTTGATCAATTCCATGTAAGTGTCCTGTGTGATTTAATTTTTT
TAAAATTTCCTTACTATGTCCACCAAATCCAGTGGTTAAGTCAATCCCTACTTGTCCTAA
TTTTATATCAAAAAAATGTAGTATTTCATCAACCATAATTGAACGATGCATACCTGCAGG
TGTATTACCCTTCTTCATAACTTTTTGAATAGTTTCTTTATACTTTTCAGGGTTTTTTTC
TTTGTATTTTTCATTATATTTTTTTGGATACAGACCACTATATCTTTTTCTTCTTACTCG
TTTATTTTCTTCCAT

>protein sequence
MEENKRVRRKRYSGLYPKKYNEKYKEKNPEKYKETIQKVMKKGNTPAGMHRSIMVDEILH
FFDIKLGQVGIDLTTGFGGHSKEILKKLNHTGHLHGIDQDPIELPKTRARLESYGFNKDN
FTLHQLNFKDFDAIDTEGFDFILADLGVSSMQIDNPDRGFTFREEGPLDLRMNPNVGIPA
YVRLLEMSEIEIEHMLIENADEIYAKEIAKEITKAKIQGRYIRTTLDLHQVIASALQKVS
KKVYEEELKKASSRTFQALRIDVNSEYEVLFEMLDKLPGKLNPGGKVAILSFHSGEDRLV
KKAFKQYLNDGVFSMTEGPILPSKEEVFNNPRARSAKLRIAIKG