ACL_RS04760

Uniprot: A9NGU2
Description: glucose-6-phosphate dehydrogenase
EC number: 1.1.1.49
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH. {ECO:0000256|HAMAP-Rule:MF_00966}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. {ECO:0000256|HAMAP-Rule:MF_00966}.
Pathway: PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. {ECO:0000256|HAMAP-Rule:MF_00966}.
Active site: ACT_SITE 233 233 Proton acceptor. {ECO:0000256|HAMAP-Rule:MF_00966}.
Binding site: BINDING 45 45 NADP. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 141 141 NADP. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 171 171 Substrate. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 175 175 Substrate. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 209 209 Substrate. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 228 228 Substrate. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 318 318 Substrate. {ECO:0000256|HAMAP-Rule:MF_00966}.; BINDING 323 323 Substrate. {ECO:0000256|HAMAP-Rule:MF_00966}.
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): zwf
Gene names (synonym):
Mass: 52,163
Subunit structure [CC]:
Gene ontology (GO): glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661]; glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098]
Gene ontology IDs: GO:0004345; GO:0006006; GO:0006098; GO:0050661
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family. {ECO:0000256|HAMAP-Rule:MF_00966}.
Protein families: Glucose-6-phosphate dehydrogenase family
Coiled coil:
Domain [FT]: DOMAIN 8 180 G6PD_N. {ECO:0000259|Pfam:PF00479}.; DOMAIN 182 430 G6PD_C. {ECO:0000259|Pfam:PF02781}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGU2
MEROPS:
EnsemblBacteria KO: ABX81572
UniPathway: K00036
CDD:
Gene3D:
HAMAP: 3.40.50.720
InterPro: MF_00966
PANTHER: IPR001282;IPR019796;IPR022675;IPR022674;IPR016040
PIRSF: PTHR23429
PRINTS: PIRSF000110
PROSITE: PR00079
Pfam: PS00069
ProDom: PF02781;PF00479
SMART:
SUPFAM:
TIGRFAMs: SSF51735

985331-986681(-)

>nucleotide sequence
TTATTTTTTATGAATATGACTCATGATATCTTTTTCATCTTCATAGACAATTACACAGTT
CGTACACTTTTTGATTTGATCGATGAAATGCCAACTTGCATCAATTTCATCCCATCTCGT
AAATAGTGTCTTATGTCCGGTAACAATATCTAAAATGAGTTTTTCATAGGCTTCTGGAAT
ATTCCCTTCAACGGATTCTGAGGTGTTAAAGGATAGTGTAACTTCTTCTAAATTTTCTTT
TAATCCAGGTTTTTTAGAGTTTATATTAAGTGCTACACCATCATTTGGTTGAATATGAAT
TGTTAGTTTATTTGGTAAAATATCTAAATGCCAGTTTTCTTGTTCATCAGTTGGGTAATA
AAGTATTTCAATATAAGATTCTTTTTTAGCCAACTTCTTACCAGTTAATATTTCAAATGG
AATACCTCTAAAACGTGGTGTATTCACATACGTTTTAAAGTAGACAAATGTTTCTGTATT
AGAGTCACTTGGAATATTTTCTTCATCCAAATAGCCCTTATATTGACCAAATACGACACT
TTCTTGATCAATTTCAAGACTTCTTAAGACTTTTACTTTTTCATCTTTAATGTAATCTGA
TTGATATTTTTTAGGTGCATCCATTGCAACTAAGGATAATATTTGTAGAAGGTGAGATTG
AACCATATCCTTTAAGGCACCAGATGTATCATAATATCCAGCTCTTGATAGGATACATTC
CTCTTCTTTTACATGGATTTTAACGGACTGAATAGATTTAGAATCCCAAGTATCTTTTAA
TATTCTATTAGCAAACCTAACAGTCATTAGATTTTGAATCATCTCTTTACCTAAGTAATG
ATCAATTCTAAATATTTGAGATTCATCAAAGTAGTTCCATAACATATCATTAACTGCCAT
TGCTGAATCTAAATCATGTCCAAATGGTTTTTCAAATACTAAGACTTGGTTTGGATTTTT
ATATTCTATCAGCTTCGATTGAGATACGTTTTTAGACACAGTTTTTAATATTTCAGGACC
TATTGCCATATAATAAATTTCTTTAGTATCTGGTTTTAACATCGGCTCAATAAATTTTTG
AAGGTTTACATAGTCTTGAGGTTCGGTGATTTGTATTTCATAATACGTTAAAATCTTATT
TAAAGTCACCATATCTAACTTTTTAGTTGTGTGCTTTTGAATGTATTCTAAATAAGCTTT
TGTATCAAAATCACGACGGCCTAGTGCAATGACTTGTAGGTTTTGTGTAATATTATTTGA
GTTATATAGTGCAGTAATTGCAGGTAATAACTTTCTTGCAGTTAAGTCACCTGTAGAACC
AAATATAACAATAATTAAGTCTTTTTTCAT

>protein sequence
MKKDLIIVIFGSTGDLTARKLLPAITALYNSNNITQNLQVIALGRRDFDTKAYLEYIQKH
TTKKLDMVTLNKILTYYEIQITEPQDYVNLQKFIEPMLKPDTKEIYYMAIGPEILKTVSK
NVSQSKLIEYKNPNQVLVFEKPFGHDLDSAMAVNDMLWNYFDESQIFRIDHYLGKEMIQN
LMTVRFANRILKDTWDSKSIQSVKIHVKEEECILSRAGYYDTSGALKDMVQSHLLQILSL
VAMDAPKKYQSDYIKDEKVKVLRSLEIDQESVVFGQYKGYLDEENIPSDSNTETFVYFKT
YVNTPRFRGIPFEILTGKKLAKKESYIEILYYPTDEQENWHLDILPNKLTIHIQPNDGVA
LNINSKKPGLKENLEEVTLSFNTSESVEGNIPEAYEKLILDIVTGHKTLFTRWDEIDASW
HFIDQIKKCTNCVIVYEDEKDIMSHIHKK