ACL_RS04865

Uniprot: A9NGW4
Description: ATP synthase subunit alpha
EC number: 3.6.3.14
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000255|HAMAP-Rule:MF_01346}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. {ECO:0000255|HAMAP-Rule:MF_01346}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 170 177 ATP. {ECO:0000255|HAMAP-Rule:MF_01346}.
Site: SITE 363 363 Required for activity. {ECO:0000255|HAMAP-Rule:MF_01346}.
Gene names (primary): atpA
Gene names (synonym):
Mass: 55,493
Subunit structure [CC]: SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. {ECO:0000255|HAMAP-Rule:MF_01346}.
Gene ontology (GO): plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; plasma membrane ATP synthesis coupled proton transport [GO:0042777]
Gene ontology IDs: GO:0005524; GO:0005886; GO:0015991; GO:0042777; GO:0045261; GO:0046933; GO:0046961
Chain: CHAIN 1 501 ATP synthase subunit alpha. /FTId=PRO_0000339011.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ATPase alpha/beta chains family. {ECO:0000255|HAMAP-Rule:MF_01346}.
Protein families: ATPase alpha/beta chains family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NGW4
MEROPS:
EnsemblBacteria KO: ABX81594
UniPathway: K02111
CDD:
Gene3D: cd01132
HAMAP: 2.40.30.20;3.40.50.300
InterPro: MF_01346
PANTHER: IPR020003;IPR023366;IPR005294;IPR000793;IPR000194;IPR004100;IPR033732;IPR027417
PIRSF: PTHR15184:SF3
PRINTS:
PROSITE:
Pfam: PS00152
ProDom: PF00006;PF00306;PF02874
SMART:
SUPFAM:
TIGRFAMs: SSF47917;SSF50615;SSF52540

1007569-1009075(-)

>nucleotide sequence
TTAGATAAATCTCCTTACGTGATCTATAAATAATTCCATTAATGCCTTATCTTTAATTGC
CTTATGTTCAACAAGTTCTTTTCTAAGTTTTTTACCAGTTTCATTTAAAGATAAACCTTG
TTCGATTTCAGCCATTAAAGACCTGATTTGTTTTAGGTTTAAATCATCCATAAAGCCATT
TTCTAGTGCATAGAATGTTACAATTTGACTTGGCATATCAATGAGTTCATGAACATCTTG
TTTTAAGATTTCAACTGTCTTACGTCCACGGTCTAAACGACGCTTAGAACTTGGGTCTAA
GTCTGAACCAAATTGTGCAAAACTTTCTAACTCTCTAAAGTTAGCCAGTGAGATACGCAA
GGTTCCAGCAACTTGTTTCATCGCCTTCCACTGAGCACTACCTCCTACACGTGATACGGA
TAACCCTGCATTAATTGCAGGTCTTACCCCTTGGTAGAACAGTTTTTGTTCTAAGTATAA
TTGTCCATCTGTAATACTAATTATATTGGTTGGAATGTAGGCACTTATATCTCCTGCTTG
TGTCTCAACAATTGGTAATGCAGTAATTGAACCACCACCATGTTCCTTACTTAATTTCCC
AGCACGCTCTAAAAGTCTTGAGTGCAGATAGAAAATATCTCCAGGATATGCTTCACGTCC
ACTTGGGCGTTTCATTAATAAAGATAATTCTCTATATGCTACAGCATGTTTTGATAAATC
ATCATAAATAATTAATACATCTTTACCTTGTTCCATAAAGTACTCAGCAATCGATGAACC
TGTATATGGCGCAATGTAAAGTAATGTTGCTTCTTTAGATGCCCCAGCATTGATAATCAC
TGTATAATCCAGTGCATCTTTAATTTGTAATAATTTGACTAGATTGGCAATCGTTGAGTC
TTTTTGTCCGATAGCAACATACACACAAATAACGTTTTTACCACGTTGATTAATAATTGT
ATCTATGGCAATTGTAGATTTTCCAGTTTGTCTATCCCCAATAATTAATTCTCTTTGTCC
TTTTCCAATTGGAACAAGTGCATCAATTACTTTGATACCTGTATGAAGTGGTTCATTTAT
AAATCCACGGTGCATTAAGTCTTTTGCAGGGCGTTCAATCGGATAGTATGCATCAGCATT
AATAGTACCTTTAAGGTCCAGTGGATTGCCTAGTGGATCTACAACTCTACCAAGTAGGTC
TTCACCTACTGGTACTTCAAATATCTTTTTAGTGGCACGAACGTTATCCCCTTCTTTAAT
GAGATCAGTACGTCCAAATAAGATAATACCTACATGAAACTGTTCTAAGTTAAACACGAG
TCCTTTAACATCATGAGGTAGTTCAACAAGTTCCCCTAGAATAGCCTGGCTTAAACCATA
AACGGTTGCAATACCATCTGCTACGCTTAAAACTTTACCAATACTTTCTAGTCGGACGTC
AGCTTTATAGTCTTCAATTTGTTTTTGTATAAGTGCACCAATTTGGTCAATATCAATTTT
AGCCAT

>protein sequence
MAKIDIDQIGALIQKQIEDYKADVRLESIGKVLSVADGIATVYGLSQAILGELVELPHDV
KGLVFNLEQFHVGIILFGRTDLIKEGDNVRATKKIFEVPVGEDLLGRVVDPLGNPLDLKG
TINADAYYPIERPAKDLMHRGFINEPLHTGIKVIDALVPIGKGQRELIIGDRQTGKSTIA
IDTIINQRGKNVICVYVAIGQKDSTIANLVKLLQIKDALDYTVIINAGASKEATLLYIAP
YTGSSIAEYFMEQGKDVLIIYDDLSKHAVAYRELSLLMKRPSGREAYPGDIFYLHSRLLE
RAGKLSKEHGGGSITALPIVETQAGDISAYIPTNIISITDGQLYLEQKLFYQGVRPAINA
GLSVSRVGGSAQWKAMKQVAGTLRISLANFRELESFAQFGSDLDPSSKRRLDRGRKTVEI
LKQDVHELIDMPSQIVTFYALENGFMDDLNLKQIRSLMAEIEQGLSLNETGKKLRKELVE
HKAIKDKALMELFIDHVRRFI