ACL_RS05390

Uniprot: A9NH70
Description: pyruvate kinase
EC number: 2.7.1.40
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate. {ECO:0000256|RuleBase:RU000504}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. {ECO:0000256|RuleBase:RU000504}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): pyk
Gene names (synonym):
Mass: 49,287
Subunit structure [CC]:
Gene ontology (GO): kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]
Gene ontology IDs: GO:0000287; GO:0004743; GO:0016301; GO:0030955
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the pyruvate kinase family. {ECO:0000256|RuleBase:RU000504}.
Protein families: Pyruvate kinase family
Coiled coil:
Domain [FT]: DOMAIN 1 340 PK. {ECO:0000259|Pfam:PF00224}.; DOMAIN 355 423 PK_C. {ECO:0000259|Pfam:PF02887}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NH70
MEROPS:
EnsemblBacteria KO: ABX81700
UniPathway: K00873
CDD:
Gene3D:
HAMAP: 2.40.33.10;3.20.20.60;3.40.1380.20
InterPro:
PANTHER: IPR001697;IPR015813;IPR011037;IPR015794;IPR018209;IPR015793;IPR015795;IPR015806
PIRSF: PTHR11817
PRINTS:
PROSITE: PR01050
Pfam: PS00110
ProDom: PF00224;PF02887
SMART:
SUPFAM:
TIGRFAMs: SSF50800;SSF51621;SSF52935

1126357-1127710(-)

>nucleotide sequence
TTATTTGATTTCTAATAATTTAGTTGAACTATTAGTTACTTCTAATACGAAGTCACCTTC
AACCAAACCTAATTTATCTAAGAACTTAGACGCTTCATCTTTACTTAATACTGGGTATAC
ACCAAAGTGAAGTGCTAACGCTCTAGCTTCTTTAGCATTTTTTACAACAGCAATGTTAAT
TGCTTGTGTATGGTATGCTGCAAATGATTTAGCTACATCAACGCCTGTTGTAATTACAAC
ATCTACTTCATACTCTAATACTAATTTAGCTGCTGATTGAGCGATTGCATCAATATTAGA
ATCTCCCATGAAGTAACCATCTAAGAACACTTCATAGTCTAATGTTGATTCAGCTTTTGC
ATCAATACTTGCCATTTTTTTAACTGATTCAATTGGGTAATCACCAGCTGCTGATTCACC
ACTTAACATTGTTGCAGAAGTTCCTTCTCTAACTGCGTTAAATACGTCAGATACTTCAGC
TCTTGTTGGGCGTGGGTTTTTTTGCATAGATTCAAGCATTTGAGTAGCAACGATTACTAC
TTTACCTAATTCTAAACATTTGTCGATCATTTCTGATTGGTACATTGGTACTAATTCACC
TTCAACTTCGATACCTAAGTCTCCACGTGCAACCATGATACCATCAACAACATCTAAAAT
GTCATCTAGGTTATCCATACCTTCTTGGTTTTCAATTTTAGCAATAATTTGAACGTCTTT
ACCACCGTTGTTATCCAAGATATCACGAACAGCTTGAGCATCTTCGCCACGTCTTACAAA
ACTTGCAGCAACAAAGTCATAACCCATAGTTGCAGCAAATTTAATATCACTTGCATCTTT
TTCGGAAATGAAAGGCATATTTAGAACAACACCTGGAATGTTTACACCACGTCTTGATTT
TACTGTATGTGTGTTTAAAGCTTTAGTTACTAATTCATTATTTTTAGTATCTTTTTCAAT
CACTTCTAATGTTAGGTAACCATCATCAACAGAAACGAATTCTCCTACTTTCATATCGTC
AAATAAACCTGGGTATGAAACAGAGAATCTTTCTTTGTTTCCTAATACTGGTGTAAATCC
GATTCTAACGATTGAATTTTTTTGGATTTCTACTTTACCATCAAATTCGTGTGTACGAAT
TTCTGGTCCTTTAGTATCAAGTAAGTAAGCAACGTGTGTGCCTAACTCCTCGTTAATTGA
TTGAATCGTTTTTAAACGGTTCCCGTGTTCTTCATAGTCTCCGTGTGAAAAGTTAAAGCG
TGCTACGTTCATACCAGCTTTAACAAGTTGTGTCATGACTGCTTTATCTTCTGATGCAGG
TCCTAATGTACAAACAATTTTTGTTTTTCTCAT

>protein sequence
MRKTKIVCTLGPASEDKAVMTQLVKAGMNVARFNFSHGDYEEHGNRLKTIQSINEELGTH
VAYLLDTKGPEIRTHEFDGKVEIQKNSIVRIGFTPVLGNKERFSVSYPGLFDDMKVGEFV
SVDDGYLTLEVIEKDTKNNELVTKALNTHTVKSRRGVNIPGVVLNMPFISEKDASDIKFA
ATMGYDFVAASFVRRGEDAQAVRDILDNNGGKDVQIIAKIENQEGMDNLDDILDVVDGIM
VARGDLGIEVEGELVPMYQSEMIDKCLELGKVVIVATQMLESMQKNPRPTRAEVSDVFNA
VREGTSATMLSGESAAGDYPIESVKKMASIDAKAESTLDYEVFLDGYFMGDSNIDAIAQS
AAKLVLEYEVDVVITTGVDVAKSFAAYHTQAINIAVVKNAKEARALALHFGVYPVLSKDE
ASKFLDKLGLVEGDFVLEVTNSSTKLLEIK