ACL_RS05415

Uniprot: A9NH75
Description: alanine dehydrogenase
EC number: 1.4.1.1
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH. {ECO:0000256|PIRNR:PIRNR000183}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. {ECO:0000256|PIRNR:PIRNR000183}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): ald
Gene names (synonym):
Mass: 39,825
Subunit structure [CC]:
Gene ontology (GO): alanine dehydrogenase activity [GO:0000286]; L-alanine catabolic process [GO:0042853]
Gene ontology IDs: GO:0000286; GO:0042853
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the AlaDH/PNT family. {ECO:0000256|PIRNR:PIRNR000183}.
Protein families: AlaDH/PNT family
Coiled coil:
Domain [FT]: DOMAIN 4 136 AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.; DOMAIN 148 295 AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NH75
MEROPS:
EnsemblBacteria KO: ABX81705
UniPathway: K00259
CDD:
Gene3D:
HAMAP: 3.40.50.720
InterPro:
PANTHER: IPR008141;IPR007886;IPR007698;IPR016040
PIRSF:
PRINTS: PIRSF000183
PROSITE:
Pfam:
ProDom: PF01262;PF05222
SMART:
SUPFAM: SM01002;SM01003
TIGRFAMs: SSF51735

1133241-1134348(-)

>nucleotide sequence
TTATCTTAAGGATTCAAATGTTATAAATTCTTTATGAAAACTTTCTGCTACATCTTTTTG
AGTGATGTATCCTTTATAGGTATTGAGTCCTTCATTGATCGAAGGATTTTCTTCTACTGA
TTTTTCTAAACCCTTATTTGCAATCTCTAGTCCAAACTTTAAAGTTGCATCATTAAGTGC
AATCGTTGCTGTTCTAGGTACAATACCTGGCATGTTAGCTACACAATAATGTGTAATACC
AGAAACTTTAAAGACTGGTTCTGAGTGTGTAGTTGGTCTACTTACTTCAGTTGATCCACC
TTGATCGATTGCGATATCGACAATCACAGTACCTTTTTTCATATCTTTATAATATGCTTT
TTTAATGAGTTTTGGTGCCTTCTTACCAGGTAATAGGACACTTGAAATCACTAAATCTGC
ATCTTTTAATGAAGCAATAATATTTGCTTCATTAGATATGAGTGTTGTTAATTTAGGATA
GATTTGTTTTAAATCGTCTAATCTTTTCTCATTAATATCTAGAATCGTGACATCACTGCC
TAATCCGTAAGCATTTTGAAGTGCTGCACTACCTGCAACACCGGCACCAATAATAGTAAC
TTTTGCAGGGTTGACACCTGTTACACCAGAAATTAATAACCCATTTCCACCATTGTTTTT
ATATAAGAATCTAGCGCCTTCTAAAACAGATAGTCTACCTGCAACCTCACTCATAGGTTT
TAATAAAGGTAGCCCTGTTTCATCACGTACAGTTTCATAAGCGATGGATGATACGCGTTT
CTTTAACAATGTTTTTAATAAGGGTTCATCTGCCGCTAAGTGCAGATATGTAAATAGAAT
TTGACCGGTTCTAATGAGTGGATACTCACTACGAACTGGCTCTTTAACTTTAATAATCAT
TTTTGACTTATGCCAAACTTCTTTTGCACTGTCTATAATGACAGCGCCTCTTTTTTTATA
TGCTGCATCGCTAAACCCTGAGGTTTTGCCTGCACCACTTTCTACCAAGACTGTGTGTCC
TGCTTTTACATAAGCTCTAACAGCATCCGGTGTTAACCCAACTCTATCTTCACTCTCTTT
TACTTCTCTAACTAATCCAATAATCAT

>protein sequence
MIIGLVREVKESEDRVGLTPDAVRAYVKAGHTVLVESGAGKTSGFSDAAYKKRGAVIIDS
AKEVWHKSKMIIKVKEPVRSEYPLIRTGQILFTYLHLAADEPLLKTLLKKRVSSIAYETV
RDETGLPLLKPMSEVAGRLSVLEGARFLYKNNGGNGLLISGVTGVNPAKVTIIGAGVAGS
AALQNAYGLGSDVTILDINEKRLDDLKQIYPKLTTLISNEANIIASLKDADLVISSVLLP
GKKAPKLIKKAYYKDMKKGTVIVDIAIDQGGSTEVSRPTTHSEPVFKVSGITHYCVANMP
GIVPRTATIALNDATLKFGLEIANKGLEKSVEENPSINEGLNTYKGYITQKDVAESFHKE
FITFESLR