ACL_RS05730

Uniprot: A9NHC7
Description: deoxyuridine 5'-triphosphate nucleotidohydrolase
EC number: 3.6.1.23
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: dUTP + H(2)O = dUMP + diphosphate. {ECO:0000256|SAAS:SAAS00071029}.
Cofactor: COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|SAAS:SAAS00171379};
Enzyme regulation:
Function [CC]: FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. {ECO:0000256|SAAS:SAAS00071014}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): dut
Gene names (synonym):
Mass: 16,147
Subunit structure [CC]:
Gene ontology (GO): dUTP diphosphatase activity [GO:0004170]; metal ion binding [GO:0046872]; dUTP metabolic process [GO:0046080]
Gene ontology IDs: GO:0004170; GO:0046080; GO:0046872
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the dUTPase family. {ECO:0000256|SAAS:SAAS00563559}.
Protein families: DUTPase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHC7
MEROPS:
EnsemblBacteria KO: ABX81757
UniPathway: K01520
CDD:
Gene3D: cd07557
HAMAP: 2.70.40.10
InterPro:
PANTHER: IPR029054;IPR008180;IPR008181;IPR033704
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF00692
SMART:
SUPFAM:
TIGRFAMs: SSF51283

1214037-1214478(-)

>nucleotide sequence
TTATTGACCAGAACTACCAAACCCACCGGTACGTTCATTAGAACTCTCATCATCACTGGT
AATAAGATATTTTTGGAAAACACCTTGAGCAACACGTTCACCTTTTTGAATGATTGCATC
TTGTTGACCAAAATTGAATAATGGAATCATAATATGTCCTTCATTATTTGGGTTATTATA
ATAATCTTTATCAATAATACCAACTGCATTCGACATAATTAAACCCTTTTTAATACCTAA
TGAAGATCTCGGATAAATCATGAGTGCTTCGTTTTCTAACATATCTACTTTTAACCCGGT
ATCGATTAATTGAATCGTACCTGGTTTGATGACGTAAGCGTCTGCACTTTCAATATCATA
ACCTGCACTATATTTAGTTGCTCTTTTAGGTAGGTTAATAGATTTATCTTTAAAACCTGT
TACTACTTCAAATTTTCTCAT

>protein sequence
MRKFEVVTGFKDKSINLPKRATKYSAGYDIESADAYVIKPGTIQLIDTGLKVDMLENEAL
MIYPRSSLGIKKGLIMSNAVGIIDKDYYNNPNNEGHIMIPLFNFGQQDAIIQKGERVAQG
VFQKYLITSDDESSNERTGGFGSSGQ