ACL_RS05785

Uniprot: A9NHD8
Description: ATP synthase subunit A
EC number: 3.6.3.14
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000256|HAMAP-Rule:MF_00309}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. {ECO:0000256|HAMAP-Rule:MF_00309}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 233 240 ATP. {ECO:0000256|HAMAP-Rule:MF_00309}.
Site:
Gene names (primary): ntpA2
Gene names (synonym): atpA
Mass: 65,219
Subunit structure [CC]:
Gene ontology (GO): proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; ATP hydrolysis coupled proton transport [GO:0015991]; plasma membrane ATP synthesis coupled proton transport [GO:0042777]
Gene ontology IDs: GO:0005524; GO:0015991; GO:0033178; GO:0042777; GO:0046933
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ATPase alpha/beta chains family. {ECO:0000256|HAMAP-Rule:MF_00309}.
Protein families: ATPase alpha/beta chains family
Coiled coil:
Domain [FT]: DOMAIN 10 69 ATP-synt_ab_N. {ECO:0000259|Pfam:PF02874}.; DOMAIN 85 204 ATP-synt_ab_Xtn. {ECO:0000259|Pfam:PF16886}.; DOMAIN 213 434 ATP-synt_ab. {ECO:0000259|Pfam:PF00006}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHD8
MEROPS:
EnsemblBacteria KO: ABX81768
UniPathway: K02117
CDD:
Gene3D:
HAMAP: 1.10.1140.10;3.40.50.300
InterPro: MF_00309
PANTHER: IPR031686;IPR000793;IPR000194;IPR004100;IPR024034;IPR027417;IPR022878
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF00006;PF02874;PF16886
SMART:
SUPFAM:
TIGRFAMs: SSF47917;SSF50615;SSF52540

1222496-1224242(-)

>nucleotide sequence
TTAGAAAATTGAATCAATCGTTTGATCAATTAGATGTTTTAACGTGTCAAATTGATCAGT
TGGTTCATTTCCGATTTCATATTTCATTTGAATGACTTGATCAAATATACCTGATTTTAA
GATTAGTGATAAAGCTTTACCTTTTTCAATAAATCTTAATGAACTATCATATAGGTATAA
AATGGTTTCAATCATGTTTAATTGTTTATGTAGTGGTACGAATGTATCCACTGCATTAAA
TGCATTTTGTTGGAGGAATCCAGTACGGATAACGCGTCCAATTTCAATTGTAAGTTTTTG
ATTATCTGGTAAAACATCACTACCCATTAAACTTGCAATTTCATTTAATTTATATTCTTC
AGCTAGTATACTTAAAATTCTACTTCTATATTTTAAGAATTTAGGATCAAGTGTATTGTC
ATACCAACTTGATAAATCATAAATATATTCAGAATAACTTAAGTTCCAGTTAATTGCAGC
AAAGTGTCTTTGATGCGCTAGTGATTTATCAAGTGCCCAAAATGCTCTAACAAAGCGTTT
AGTATTTTGAGTAACTGGTTCACTAAAGTCTGCTCCTTGTGGAGAAACTGCACCAATAAT
TGAAACTGATCCCGTAGATCTGTTTTGATTAATCATCATACCAGCACGTTCGTAGAATTT
AGAGATACGGCTTGGTAAGTAAGATGGATAACCTTCTTCAGCAGGAATTTCTTCAAGTCT
TGCTGAAATTTCACGAAGTGCTTCTGCCCAACGTGATGTAGAGTCGGCCATAATCGCAAC
ATGATAACCCATATCACGGTAGTATTCAGCAACCGTAAGACCAGTATAAATACTAGCTTC
TCTGGCTGCAACTGGCATGTTGGATGTGTTTGCAATTAAAATGGTTCTATCCATTAAAGT
TTGATTGGTTCTTGGATCGACTAACTTCGTAAATTCTTCCAAGACTTGTGTCATTTCATT
TCCACGTTCCCCACAACCTACATAAACGATAATGTCTGCATCAGACCATTTAGCGAGTTG
ATGTTGTAACATGGTTTTACCTGTACCAAATCCACCAGGAATTGCAGCTGTACCACCTTT
TGCAATTGGAAATAAAGTGTCAATGACACGTTGTCCAGTAATCAGTGGTGTAGATAATTC
AAGTCTTTCTGTAACAGGTCTTGCTTTTTTAATTGGCCATGTTTGGTATAGTTTTAATTC
CACATCGCCTGCTTTAGTTTCTAATACTAAAACAGTATCTTTAACTTTATACGTTCCAGA
AGGTTTCACTGATTTTGCAATACCTTCTATATGTGGTGGCACCATTAAACGATGTTCAAT
CGCACTGGTCTCTTTAATCACTGCATATACCATACCGCAACCTAAATAGTTACCTTCTTG
AACTTTAACTTCGACATCAAATGTTTGTTCAAAATCCAAACTTGGAATATTAGAACCAGC
TTTAATAAATGGACCATCAGAGTCTTTTATTTTTTGAAGTGGTCTTAAAACCCCATCAAA
AATATTACCCATTAAGCCAGGTCCAAGCATGACTGAAACAAGTTCACCTGTAGGGTAAAC
TAAGTCACCAACTTTTAAACCTTGTGTGGTTTCATAAACTTGGATAACTGTTTCAGTATC
AGAAATGGAAATGACTTCTCCAATTAATCTTTTTGGTCCAACATAGACCATTTCTAACAT
CTTAAATTCGTCTGTAGAACCTAGTTTAACAACTGGTCCGTTAATTACTTTAATTGTATT
TTTCAT

>protein sequence
MKNTIKVINGPVVKLGSTDEFKMLEMVYVGPKRLIGEVISISDTETVIQVYETTQGLKVG
DLVYPTGELVSVMLGPGLMGNIFDGVLRPLQKIKDSDGPFIKAGSNIPSLDFEQTFDVEV
KVQEGNYLGCGMVYAVIKETSAIEHRLMVPPHIEGIAKSVKPSGTYKVKDTVLVLETKAG
DVELKLYQTWPIKKARPVTERLELSTPLITGQRVIDTLFPIAKGGTAAIPGGFGTGKTML
QHQLAKWSDADIIVYVGCGERGNEMTQVLEEFTKLVDPRTNQTLMDRTILIANTSNMPVA
AREASIYTGLTVAEYYRDMGYHVAIMADSTSRWAEALREISARLEEIPAEEGYPSYLPSR
ISKFYERAGMMINQNRSTGSVSIIGAVSPQGADFSEPVTQNTKRFVRAFWALDKSLAHQR
HFAAINWNLSYSEYIYDLSSWYDNTLDPKFLKYRSRILSILAEEYKLNEIASLMGSDVLP
DNQKLTIEIGRVIRTGFLQQNAFNAVDTFVPLHKQLNMIETILYLYDSSLRFIEKGKALS
LILKSGIFDQVIQMKYEIGNEPTDQFDTLKHLIDQTIDSIF