ACL_RS05985

Uniprot: A9NHH8
Description: phosphoglycerate kinase
EC number: 2.7.2.3
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. {ECO:0000255|HAMAP-Rule:MF_00145}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. {ECO:0000255|HAMAP-Rule:MF_00145}.
Active site:
Binding site: BINDING 37 37 Substrate. {ECO:0000255|HAMAP-Rule:MF_00145}.; BINDING 120 120 Substrate. {ECO:0000255|HAMAP-Rule:MF_00145}.; BINDING 157 157 Substrate. {ECO:0000255|HAMAP-Rule:MF_00145}.; BINDING 208 208 ATP. {ECO:0000255|HAMAP-Rule:MF_00145}.; BINDING 296 296 ATP; via carbonyl oxygen. {ECO:0000255|HAMAP-Rule:MF_00145}.; BINDING 327 327 ATP. {ECO:0000255|HAMAP-Rule:MF_00145}.
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 355 358 ATP. {ECO:0000255|HAMAP-Rule:MF_00145}.
Site:
Gene names (primary): pgk
Gene names (synonym):
Mass: 42,767
Subunit structure [CC]: SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00145}.
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; glycolytic process [GO:0006096]
Gene ontology IDs: GO:0004618; GO:0005524; GO:0005737; GO:0006096
Chain: CHAIN 1 399 Phosphoglycerate kinase. /FTId=PRO_1000076578.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the phosphoglycerate kinase family. {ECO:0000255|HAMAP-Rule:MF_00145}.
Protein families: Phosphoglycerate kinase family
Coiled coil:
Domain [FT]:
Motif:
Region: REGION 21 23 Substrate binding. {ECO:0000255|HAMAP-Rule:MF_00145}.; REGION 60 63 Substrate binding. {ECO:0000255|HAMAP-Rule:MF_00145}.
EMBL: CP000896
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: ABX81808
UniPathway: K00927
CDD:
Gene3D: cd00318
HAMAP: 3.40.50.1260;3.40.50.1270
InterPro: MF_00145
PANTHER: IPR001576;IPR015901;IPR015824
PIRSF: PTHR11406
PRINTS: PIRSF000724
PROSITE: PR00477
Pfam:
ProDom: PF00162
SMART:
SUPFAM:
TIGRFAMs: SSF53748

1257624-1258824(-)

>nucleotide sequence
TTAGATTACATCTACCAATTCTACACCTGGTAGTACTTTACCTTCTAGATATTCTAAAGA
TGCACCACCACCGGTTGAGATGTGACTAAATTTATCTTCAAGACCAAATTTTGCAACCGC
TGCTGCAGAGTCTCCACCACCAACGATTGTAATTGCTTTACCATGTAAGTCAGCTAACGC
TTTAGTTACTTCTAATGTACCATTAGCGAATTTTTCCATTTCAAATACGCCTTGAGGTCC
ATTCCATACAACTGTTTTAGCACTTGCAATAATTTCTTTAAATCTTGCTACTGTCTTAGG
TCCAATATCTAAGCCCATTTCATCTGCTGGAATTGCATCAAATGATCTTACATTCGTTTC
AGTATCTTTATCAAATGCTTTACCTGTAACAACATCAAAACCTAATTCAATTTTACCCTT
AGATAACTCAAGTAATTCTTTAGCTAAATCTAATTTATCTAATTCTACTAAGGATTTACC
TACTTCAAAGCCTTGAGCTTTTAAGAATGTAAATGCCATACCGCCACCGATTAATACTTT
ATCAGCAACTTTTAATAAGTTTTTAATCACTTCAATTTTATCAGATACTTTAGCACCACC
TAAAATCGCAACGAATGGTCTTTCAGGATTTTCTAAAGCACCACCAATAAAGTTAATTTC
TTTTTCAAGTAATAAACCTGCAACAGAAACTTCCATATTGTTTGCAATACCAACGTTAGA
AGCATGTGCTCTATGTGCTGTACCAAATGCATCATTTACAAATACATCCCCTAATGATGC
CCAGTATTTACCTAACTCTGGATTGTTTTTAGATTCTTTGTTTCCATCTAAATCTTCAAA
GCGTGTGTTTTCAAACATTAACACATCACCTGATTTTAGATTCTTAACTGCAGCCTCTAA
AGCTTCACCTCTAGTTTCAGGAATAAATACAACAGGTCTGCCAATTAATTCTGATAATCT
AGCAGCAACTGGTTTCAGTGAGTTTGTTGCTTTATCTTCAGCTGTTTTAATACGCCCTAA
GTGTGAGAATAATATTAACTTAGCACCCTTTTCAATTGCATATTCAATTGTAGGTAAAGC
AGCTGTAATACGTGTATCATCTGAGATAGATCCGTCTTTATTCAAAGGAACATTGAAGTC
TACGCGCATTAATACACTCTTGTTTTTTAATTCGATGTCTCTAATAGTTTTTTTAGCCAT

>protein sequence
MAKKTIRDIELKNKSVLMRVDFNVPLNKDGSISDDTRITAALPTIEYAIEKGAKLILFSH
LGRIKTAEDKATNSLKPVAARLSELIGRPVVFIPETRGEALEAAVKNLKSGDVLMFENTR
FEDLDGNKESKNNPELGKYWASLGDVFVNDAFGTAHRAHASNVGIANNMEVSVAGLLLEK
EINFIGGALENPERPFVAILGGAKVSDKIEVIKNLLKVADKVLIGGGMAFTFLKAQGFEV
GKSLVELDKLDLAKELLELSKGKIELGFDVVTGKAFDKDTETNVRSFDAIPADEMGLDIG
PKTVARFKEIIASAKTVVWNGPQGVFEMEKFANGTLEVTKALADLHGKAITIVGGGDSAA
AVAKFGLEDKFSHISTGGGASLEYLEGKVLPGVELVDVI