ACL_RS06385

Uniprot: A9NHQ5
Description: ribonucleotide-diphosphate reductase
EC number: 1.17.4.1
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. {ECO:0000256|RuleBase:RU003410}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. {ECO:0000256|RuleBase:RU003410}.
Pathway: PATHWAY: Genetic information processing; DNA replication. {ECO:0000256|RuleBase:RU003410}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): nrdE
Gene names (synonym):
Mass: 79,987
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; DNA replication [GO:0006260]
Gene ontology IDs: GO:0004748; GO:0005524; GO:0006260
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large chain family. {ECO:0000256|RuleBase:RU003410}.
Protein families: Ribonucleoside diphosphate reductase large chain family
Coiled coil:
Domain [FT]: DOMAIN 559 581 RIBORED_LARGE. {ECO:0000259|PROSITE:PS00089}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: ABX81885
UniPathway: K00525
CDD:
Gene3D:
HAMAP:
InterPro:
PANTHER: IPR013346;IPR026459;IPR000788;IPR013509;IPR013554;IPR008926
PIRSF:
PRINTS:
PROSITE: PR01183
Pfam: PS00089
ProDom: PF02867;PF00317;PF08343
SMART:
SUPFAM:
TIGRFAMs: SSF48168

1347076-1349179(-)

>nucleotide sequence
TTAGACTGCACAAGATTCACACTCTTCAATTTTTAATTTTTGAGTACGTGTGTAGTATAG
TGTTTTGATACCTTGGTAGTGTGCATATAAGTAATATTTTTGTAGTTCTCTTGTTGTAAT
ATCAGATGTAATACATAGTTCAAATGAAATACCTTGGTCTACGTGCTTTTGTGCAGTAGC
AATCACATCAATTAAACGATATGTATCCATACGGTATGCTGTTTCATACATAAATGCTGC
CTTTTCTACTGCTGGCATAGGGTAGTATGTTTTTGAGTTACCATAAGTTCTTTCTTCTAC
TAATTGTTTAATTGGTGTAAGTGATGGTGTTGCACTCATCACATACCCAATTGAACCATT
TGGTGCAACCGCTAAGCGGTGTGAGTTATATAAACCATGTGTCATGACATCTTCTTTAAG
TTGTAGCCAATCATCATCAGTTGGTATATAAACGTTTTTAAATAGTTCCTTGACTTTGTC
TGTTTTAGGTAGTATTTGACCACGTCCATCAAAGTAAGAACCATCTGCATATTTAGACTT
TTCAAAACGGTGGAACTTTTCACCAGTTTCTTTAGCTTTTTCCATAGAGTGTACTAAAGA
ATAATAGTTTACAATATTAAAGAATACATCGATTAAATCAATATTCTCATCACTACCATA
CATAATATAGTTTTCAGCAATATAGCCGTGATGACCCATAATACCAAATCCAACAGATCT
ATTTAATCTGTTAGCTTTAGCAACAGCTGGTACGTGTTTGATATCTGTTTGATTTGAAAC
AGAGTTCATCACGTCCATTGCACCAAATACAGTTTCTTTAATGGTATTGTGTTTCATCAT
GTTACCCATATGACCACTTGCTAGGTTACACGAAATATCCATACCTATTTCATCGTTATT
TGCACCATAATCACCATAGTGTGAAGTAATCGTTGGTTGCAAGATTTCTGTACATAGGTT
TGAGAACTTCACAGGCATATCTAGTGGATTTGCCTTGTTAACGTTATCTGAAAACATAAT
ATAAGGGTAACCCGACTCACCTTGTAGTTGAGCAATCATATCTAATATTTTTCTAGGGTT
AACTTTACGTTTTCTAACCAATGGATTATCTGCTAAAATATCATACCAGTGATCCATATC
AATAGAGATATCAGCAAAGTCTTTACCGTATTGTTCAAATACGGTATGTGGGTAGAATAA
CCACATATCTTTGTTATCTCTTGCTAGTTCCATAAATTTATCAGGAATAACGACACCCAT
TGATAATGTCTTAGCACGAATATCATCATCTGCATTTAATTTCTTAGTTGCTAAGAAATC
TTCAATGTCAGCATGAAATACGTTTAAGTACACTGCACCAGCACCAGTTCTTTGGCCCAT
TTGGTCCGCGTATCTAAAGTTGTTATCTAGTAGTTTTACAACCCCTACAACACCTTTAGA
AACGTTAGGAATACCTTTAATAGCTTCACCTTTAGCGCGTAGGTTTGTCAGGTTAATACT
TACACCACCACCGACTTTAGATAACTGCATACTAAACTCAGATATTCTTGAAATATCATT
TAAAGAGTCCCCTGCTTCAAGTAAGAAACAAGATACAAACTCACCGCGTTTAGATTTACC
AGTATTAAGTAGTGTTGGTGTTGCTGGTGTAAAGTCTTGACTAATTAATAATCTAATTAA
GTTTCTTGCTTTATCAAAATCACCATTCGCGTGATATAGTGCATTCACTGCTAATCTATC
TTCATAACGTTCTAGATAGTTTTTACCCGTACGATCTTTTAAGGCATAGTCATTATAGAA
CTTAAATGCACCCATATAGGTAGGGAATCTAAATTTAGCTGCATATGCGATGTCATAGAT
AGTTTGAATTTGTTCCATCGTATATTTTGCTAAAAACTCTTTTTCATAATAGTCATTTTC
GACTAAGAACTCTAACTTTTCTTCTAATGAGTGAAAAAACTGGGTACGTTTATTCACCTC
ATTTAGAAAGTAGCTTTTAGCAGCTGCCTTATCTTTACTGATATCTTTAATCTCACCATT
TTCATCGGTGATTTGATTATTTAATACAACCCACTCAGGGATTACATCTCTTTTTTGATC
CAT

>protein sequence
MDQKRDVIPEWVVLNNQITDENGEIKDISKDKAAAKSYFLNEVNKRTQFFHSLEEKLEFL
VENDYYEKEFLAKYTMEQIQTIYDIAYAAKFRFPTYMGAFKFYNDYALKDRTGKNYLERY
EDRLAVNALYHANGDFDKARNLIRLLISQDFTPATPTLLNTGKSKRGEFVSCFLLEAGDS
LNDISRISEFSMQLSKVGGGVSINLTNLRAKGEAIKGIPNVSKGVVGVVKLLDNNFRYAD
QMGQRTGAGAVYLNVFHADIEDFLATKKLNADDDIRAKTLSMGVVIPDKFMELARDNKDM
WLFYPHTVFEQYGKDFADISIDMDHWYDILADNPLVRKRKVNPRKILDMIAQLQGESGYP
YIMFSDNVNKANPLDMPVKFSNLCTEILQPTITSHYGDYGANNDEIGMDISCNLASGHMG
NMMKHNTIKETVFGAMDVMNSVSNQTDIKHVPAVAKANRLNRSVGFGIMGHHGYIAENYI
MYGSDENIDLIDVFFNIVNYYSLVHSMEKAKETGEKFHRFEKSKYADGSYFDGRGQILPK
TDKVKELFKNVYIPTDDDWLQLKEDVMTHGLYNSHRLAVAPNGSIGYVMSATPSLTPIKQ
LVEERTYGNSKTYYPMPAVEKAAFMYETAYRMDTYRLIDVIATAQKHVDQGISFELCITS
DITTRELQKYYLYAHYQGIKTLYYTRTQKLKIEECESCAV