ACL_RS06470

Uniprot: A9NHS2
Description: lipoate--protein ligase A
EC number: 2.7.7.63
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Predicted
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. {ECO:0000256|SAAS:SAAS00511528}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): lplA2
Gene names (synonym):
Mass: 34,936
Subunit structure [CC]:
Gene ontology (GO): ligase activity [GO:0016874]; nucleotidyltransferase activity [GO:0016779]; protein lipoylation [GO:0009249]
Gene ontology IDs: GO:0009249; GO:0016779; GO:0016874
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Contains BPL/LPL catalytic domain. {ECO:0000256|SAAS:SAAS00514708}.
Protein families:
Coiled coil:
Domain [FT]: DOMAIN 26 210 BPL/LPL catalytic. {ECO:0000259|PROSITE:PS51733}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHS2
MEROPS:
EnsemblBacteria KO: ABX81902
UniPathway: K03800
CDD:
Gene3D:
HAMAP:
InterPro:
PANTHER: IPR004143;IPR004562
PIRSF:
PRINTS:
PROSITE:
Pfam: PS51733
ProDom: PF03099
SMART:
SUPFAM:
TIGRFAMs:

1365057-1365975(+)

>nucleotide sequence
ATGAAAACTATACATGCAATCAGTCAAGATCCTTACTTTAATTTAGCTTGGGAAGAATAT
ATATTTAAACATATCCATAAAGATGAAGACATCTTTTTGTTGTGGCAAAATGCCCCTTCT
ATCATAATTGGAAGAAATCAAAATGTATTTGAAGAAGTCTATTTAGATTATATTGTTAAA
CATCATATACCCCTGATACGTAGAAACTCAGGTGGTGGTACAGTCTATCATGATCTAGGT
AATATTAATTTTAGTTTTATGACAAGCGCTAAAGGCACAATCAATAATTATAAGTTGATG
ACAGAAAAGATCAGGGAAGCTTTAAAAAAGTTAGGTATACCAGTTGAATTTATCGAAAAG
TCAGACTTAAAAGTGAATGGTTTAAAGGTTAGTGGTAATTCTCAGTTCGTCTTTAAAGAT
AAACTACTGCATCACGGCACACTACTTTTCGACTCTAATTTAGATACACTAAATAGCGTG
ATTAAACCTAAACATGATGCAATCGATAGTATCGGTGTGAAGTCCAATCGTTCTTTAGTG
ACAAACTTAAAAGAATATACTTCCCTTTCTATTGAAGAATTTAAGGCTTATTTACTCAAA
GAAATAAGTGGTGAAAGTGAAGTATTAGAATTATCTACCAAAGATATTAAGAAAATTGAA
ATGCTTAAAGAAGAACGTTACTTATCATTTAACTGGAATTATGGACAATCTCCAAAATCC
ACAATTATTAAGTCTTTGGGGGACTACAGTATTAAATTGACTGTGAGTTTTGGTCATGTT
GAGGACTGTTTTATTATGCATGAAGGTACGGTTGCACTTTCTTTATCATCTAGTTTAGTT
GGGGAAAGACTTTTCCCAACCGACTTAAGTTTCTTAAAGAAAAAAGCACCTGAAGTATAT
CAGATGCTTTTTGAATAA

>protein sequence
MKTIHAISQDPYFNLAWEEYIFKHIHKDEDIFLLWQNAPSIIIGRNQNVFEEVYLDYIVK
HHIPLIRRNSGGGTVYHDLGNINFSFMTSAKGTINNYKLMTEKIREALKKLGIPVEFIEK
SDLKVNGLKVSGNSQFVFKDKLLHHGTLLFDSNLDTLNSVIKPKHDAIDSIGVKSNRSLV
TNLKEYTSLSIEEFKAYLLKEISGESEVLELSTKDIKKIEMLKEERYLSFNWNYGQSPKS
TIIKSLGDYSIKLTVSFGHVEDCFIMHEGTVALSLSSSLVGERLFPTDLSFLKKKAPEVY
QMLFE