ACL_RS06665

Uniprot: A9NHV9
Description: excinuclease ABC subunit A
EC number:
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571360}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 33 40 ATP. {ECO:0000256|HAMAP-Rule:MF_00205}.; NP_BIND 638 645 ATP. {ECO:0000256|HAMAP-Rule:MF_00205}.
Site:
Gene names (primary): uvrA
Gene names (synonym):
Mass: 105,074
Subunit structure [CC]: SUBUNIT: Forms a heterotetramer with UvrB during the search for lesions. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571359}.
Gene ontology (GO): cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; zinc ion binding [GO:0008270]; nucleotide-excision repair [GO:0006289]; SOS response [GO:0009432]
Gene ontology IDs: GO:0003677; GO:0005524; GO:0005737; GO:0006289; GO:0008270; GO:0009380; GO:0009381; GO:0009432; GO:0016887
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571366}.; SIMILARITY: Contains 1 ABC transporter domain. {ECO:0000256|RuleBase:RU363033}.; SIMILARITY: Contains 2 ABC transporter domains. {ECO:0000256|HAMAP-Rule:MF_00205}.
Protein families: ABC transporter superfamily, UvrA family
Coiled coil:
Domain [FT]: DOMAIN 597 934 ABC transporter. {ECO:0000259|PROSITE:PS50893}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHV9
MEROPS:
EnsemblBacteria KO: ABX81939
UniPathway: K03701
CDD:
Gene3D:
HAMAP: 3.30.1490.20;3.40.50.300
InterPro: MF_00205
PANTHER: IPR003439;IPR017871;IPR013815;IPR027417;IPR004602
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00211;PS50893
ProDom: PF00005
SMART:
SUPFAM:
TIGRFAMs: SSF52540

1405099-1407913(-)

>nucleotide sequence
TTATAATAAATCTTTTAAATATCTTCCAGTATAACTATTCATATTTTTAGCTAACTCTTC
TGGTGTACCCATACCTACAATATAACCACCTGCTTGACCACCATCTGGACCTAAGTCGAT
AATATGGTCTGCATTCTTGATCACATCTAAGTTATGCTCTATGACAACCATAGTTGCTCC
TTGGTCTACAATTCTGTGTAATACGCTTACTAAGCGTTTTACGTCATCTGTATGTAGTCC
GGTTGTAGGTTCATCTAGAATAAATAATGTTTTAGATGTAATACGTTTATAGAGTTCTGA
TGCAAGTTTCACACGTTGTGCCTCACCACCAGATAAGGTTGGTGCGGATTGTCCTAACCT
AATGTAACCTAAACCTACATCTTGAATGGTCTTTAGTTTATCATAAATCTTAGGATGGTT
TTCAAAGAAACTTACAGCTTCATCAATTGTCATATCTAATACATCAGCAACAGACTTACC
ACGGTATTTTATTTGAAGGGTTTCATGATTATATCTTGTGCCTCCACAAACCTCACATGG
TACATAAACATCTGGTAAGAAGTGCATACTAATTTTAATCACACCATCACCGCTACAATG
TTCACAACGTCCACCACGTACGTTAAATGAAAATCTGCCCTTTTTATAACCGCGCATCTT
AGCTTCATTGGTAAGTGCGAAGACATCTCTAATGTCATCAAATACACCCGTATATGTTGC
AGGGTTACTTCTTGGGTTATAGCCGATTGGGGATTGTGATATTTCTATAATTTTATCAAT
ATAACCATAGTCTTGAATCATATCATGTCGTCCTGCTAATTCTTTAGAACGATATAATTT
TTGTCGAAGTCCTTTTAATAAAATTTCATTCACTAATGTAGACTTACCACTACCAGATAC
TCCTGTAACAAGTGTTAACTTAGATAATGGTATAGCAACCGAAATATCTTTTAGATTATT
TTCTTTAGCACCAATAATCATGATATCTTTTCCGTTACCTTTACGTCTTACCTTAGGTAC
TTCTACTTTAAGTTCACCTTTTAAATATTTACCAGTTAAACTGTTTGGATTATCCATAAC
TTCTTGTGGGGTTCCAGCAGCCATAATAAGTCCACCGTGTTCACCAGCATATGGTCCAAT
ATCGACTAAATAATCAGATTCTAACATGGTGTCATGATCGTGTTCTACAACAATTAAAGT
ATTACCAAGATCTCTCATTTTTTTAAGTGAGTTGATAAGTCTTTCATTATCTTTTTGATG
TAAACCAATACTTGGTTCATCTAAGACATATAATACACCTGAAAGTTTTGAACCAATTTG
AGTAGCTAATCGAATACGTTGTGCCTCACCACCTGAAAGGGTGGCTGCACCACGTGCTAG
ATTTAAGTAGCCTAATCCTACATCATCTAAGAAGATAAGGCGGTGACCAATTTCTTCAAG
TAATAGTTTTGAAATTTGTTGTTGTTCGTTGTTTAAATCGAGATTAAAAATTAAATCTTT
GAGTTCTTCGACTGGTTTATCCATCATTTCGCTAATATTTAATTTTTTAATCTTTACAGA
TAATGCCGCTTCATTTAAACGGTGTCCCTTACATACAGGACAAGTAGATTCAGACATAAA
GGATTCAATCCATTTACGAATCCAATCGGATGTGGTTTCAATATATCTTCTGTTTAAGTT
TTCAATAATCCCTTCAAACTTAACACGTTTTTCATGACGTCTACCGCTATTAGATACTAA
ACTAAATTCAATTTTTTCTTTTGTACCATAAAGGATAATATCTAACTTATCTTCTGGTAT
TTCTCTAATTGGTTGGTAAGGATCAATACCATAGTGTGCACACACAGTTTCAATTTCTTG
AATGTTTAAGTTATTTTCATCTGCGTGACGATAAGGAATAATACCACCATCAAGTAATCC
TTTTTCAGGATTAACAACTAATTCTTTAGCAACTTCCATTTTTAGTCCTAAACCATTACA
GTGTGGACAAGCACCAATTGGTGTATTAAATGAAAATAATCTAGGTTCTAGTTCAGGTAT
TGTAAAATCACTGCCCTCACAAAAGAAGCGCTCACTAAAATCAATTACTTCATGTTCGTT
TACGATGATTCGAGTTTTACCTTCACCAAATTTAGCAGCCATCTCCATAGCATCATATAC
TCTAGATCTAATACCTTCTTTAATGACTAATCTATCAATGACTACTGCAATATCATGAAA
TTTATTTTTATCTAATGTTTCCATCTCTTCAATTAAGTGTACTTGACCATCGACCCAAAC
ACGCGTAAAGCCTTCTTTTAACCAGCTAGCTAATTTTTCTTTATGTGTGCCTTTTTGTCT
ATTAATTGTAGGTGCTACAATAATTACCTTAGAATTTTCAGGTAGTTTTAAAACACGAAG
TGTCATTTCTTCGATGGTTTGTTTGGTTACAGGTGTATCAGATCCCGGACAATACGGAAC
CCCTACACGAGCGTATAGTAATCTAAAGTAATCATAGATCTCAGTTACCGTACCAACTGT
AGATCTTGGGTTATTAGACGTTGTTCTTTGGTCAATTGAAATACTTGGTGATAAACCTTC
TATTGAGTCAACATCCGGTTTTTCATAGTTACCTAAAAACTGTCTAGCATAACTAGATAA
CGACTCCATATAGCGTCTTTGACCTTCTTGATAGATCGTGTCAAATGCTAAACTTGACTT
ACCACTACCAGAAACACCAGTCATAACAACCAGTTTGTTTTTAGGAATATCTAAGTCTAT
ATTTTTTAAATTATTTTCTCTTGCGCCTTTAATGCGTAACCAATCATTATTCAT

>protein sequence
MNNDWLRIKGARENNLKNIDLDIPKNKLVVMTGVSGSGKSSLAFDTIYQEGQRRYMESLS
SYARQFLGNYEKPDVDSIEGLSPSISIDQRTTSNNPRSTVGTVTEIYDYFRLLYARVGVP
YCPGSDTPVTKQTIEEMTLRVLKLPENSKVIIVAPTINRQKGTHKEKLASWLKEGFTRVW
VDGQVHLIEEMETLDKNKFHDIAVVIDRLVIKEGIRSRVYDAMEMAAKFGEGKTRIIVNE
HEVIDFSERFFCEGSDFTIPELEPRLFSFNTPIGACPHCNGLGLKMEVAKELVVNPEKGL
LDGGIIPYRHADENNLNIQEIETVCAHYGIDPYQPIREIPEDKLDIILYGTKEKIEFSLV
SNSGRRHEKRVKFEGIIENLNRRYIETTSDWIRKWIESFMSESTCPVCKGHRLNEAALSV
KIKKLNISEMMDKPVEELKDLIFNLDLNNEQQQISKLLLEEIGHRLIFLDDVGLGYLNLA
RGAATLSGGEAQRIRLATQIGSKLSGVLYVLDEPSIGLHQKDNERLINSLKKMRDLGNTL
IVVEHDHDTMLESDYLVDIGPYAGEHGGLIMAAGTPQEVMDNPNSLTGKYLKGELKVEVP
KVRRKGNGKDIMIIGAKENNLKDISVAIPLSKLTLVTGVSGSGKSTLVNEILLKGLRQKL
YRSKELAGRHDMIQDYGYIDKIIEISQSPIGYNPRSNPATYTGVFDDIRDVFALTNEAKM
RGYKKGRFSFNVRGGRCEHCSGDGVIKISMHFLPDVYVPCEVCGGTRYNHETLQIKYRGK
SVADVLDMTIDEAVSFFENHPKIYDKLKTIQDVGLGYIRLGQSAPTLSGGEAQRVKLASE
LYKRITSKTLFILDEPTTGLHTDDVKRLVSVLHRIVDQGATMVVIEHNLDVIKNADHIID
LGPDGGQAGGYIVGMGTPEELAKNMNSYTGRYLKDLL