ACL_RS06685

Uniprot: A9NHW3
Description: DNA helicase II
EC number: 3.6.4.12
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. {ECO:0000256|SAAS:SAAS00553768}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): uvrD
Gene names (synonym):
Mass: 81,502
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; DNA binding [GO:0003677]
Gene ontology IDs: GO:0003677; GO:0004003; GO:0005524
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the helicase family. UvrD subfamily. {ECO:0000256|SAAS:SAAS00597767}.; SIMILARITY: Contains uvrD-like helicase ATP-binding domain. {ECO:0000256|SAAS:SAAS00553567}.
Protein families: Helicase family, UvrD subfamily
Coiled coil:
Domain [FT]: DOMAIN 8 284 UvrD-like helicase ATP-binding. {ECO:0000259|PROSITE:PS51198}.; DOMAIN 285 560 UvrD-like helicase C-terminal. {ECO:0000259|PROSITE:PS51217}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHW3
MEROPS:
EnsemblBacteria KO: ABX81943
UniPathway: K03657
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro:
PANTHER: IPR014017;IPR000212;IPR027417;IPR014016
PIRSF: PTHR11070
PRINTS:
PROSITE:
Pfam: PS51198;PS51217
ProDom: PF00580;PF13361
SMART:
SUPFAM:
TIGRFAMs: SSF52540

1415289-1417401(-)

>nucleotide sequence
TCAGTTTTTCTTAATACTTGGATGTGACTCTAATAATTGTTTAATACCATGAGGCATACT
AAATGCGATTGTTGCAATATCTTTATCTACACTCACTACAATACCTTTACCAAATACTTG
GTGTGTGACACTATCACCAGGTTTTAGGTAGTTACTACTTGTTGATTGTTGTGGTGTGTA
GTTACCCTTTTTAGTAAAGACTTCTTGTTCAGGCATCATTTCTTTTAAGAACCTAGATGG
TCTTGGATAAATTAATGCGCCATATAATAATCTTTTCTCACTACGGGTTAAGTAAAGTCT
TTCTTTAGCTCTTGTAACACCTACATAGGCGATACGTCTTTCTTCTTCTAGTTCATTTAA
GTCCATAAAGGATTGACTTGAAGGGAAAATTTGTTCTTCCATAACCGTCATAAATACCAC
TTTAAATTCTAAGCCTTTAACTTGGTGGAAGGTTGAGAGTACTACTGCATCACTGACCTT
ATTTCTATCAAGGTCACTATAAAGTGCAATTTGATCTAAAAGCTGCATGAGCTTTTCAAG
GAAGGTTCCCTCATAATAGGCTTCAGCTTGAACAAATGGGTTCTTTAATTCTTTAATGTA
TTCAATACGTTCTTCTGAGTATTCATCTTTATCCGTTTCAAGCATTTGATTATAGCCTGT
TTTATAGGCTACATAATCCACTACTTTGCCTAACTCAGTAAAGTTTTGAAAGTCAAATTT
CATTTCTAAAATTAGGGTTTTAAACTCAAGTAGGGACTGTTTTGTTTTACCGGATATATC
AAATGAATCAATGGCATCAAACATCGACATGTTATGTTCTTTCGCATAACTTTGAAGTTT
GTTTAATGTAGTTGGTCCAATAGCTCTTCTTGGTGTATTAATAATACGCATTAAATAAAA
GTCTAAGTTAGGATCTACAACTAATCTAATGTAGGCTAGAATATCTTTAATTTCTTTTCT
TTGATAAAAAGATATACCACCATATAACACATAAGGAATATTGTATTTCATGAAGACGTC
TTCAAAACTTCTACTTAAGGCATTATTTCTATATAAAATAGCAATATCAGAATATTTATA
ACCACCATCTTTGATAAGTGTTTCAATTTCATTGGCAATCATTTGAGCTTCGTTTAAATC
GCTTTGTGCTGACCAGATAAATGGTTTTAAACCATTTCCCAAATCTGTTTCAAGTGATTT
TGAAAAGGGTCTATTTTTATTGCTAGTAATTAACTTATTAGCAAACTTTAATATTTCTTT
AGTTGATCTATAGTTTAAGTCTAGAACAATCTCTGCTTTACTACCGTCTTCATTTTTAAA
GTCATTTAAAAAGAATTTGGCATTATCATAGTTTGCACCACGAAAGGCGTAGATTGATTG
ATCAGGGTCCCCTACCACAAATAGATTTTTTTGCTTTCCCGCAAGTAGTTTCATCATTTT
ATACTGTAGATGGTCTGTATCTTGGAACTCATCGACTAAAATAAAGTTAAATTTGTTTTG
ATAGTACTCTAATATATGTTGATGTTCATCAAATAACTTATAGGTAAGTATTTGAAGATC
ATCAAAATCTAGTAAATTATTGGTGATGAGCTCATGTGTATATTTTTCTAATACCAATCT
TTCATTCGCATTATCAAAATAATCGATATTTAGATGCTTAAATAAAGATATTTTATGTCT
TATAGCGTTTGCTTTATAAGATTTAGTGTCTAGGTTTAAATCTTTAATAATCTTTCTAAC
CATCGCTTTAGCATCATCTTCATCGATGATGTTAAAGTTAACGGTATAACCCATTTTTAG
ATGTTCAATATCTCTTCTTAAGACTTTGACGCCAAACGCGTGGAATGTATATATCCATGT
ATTTGTCGCATAAGGTCCAGCCATTTCAACGATACGTTCTTTCATTTCTCTGGCTGCTTT
ATTGGTAAATGTTACCGCTAAGATACTATCTGGGGCTACGCCTAGTTCTTCAATTAAATA
TGCAATTCTAGTGGTTAGTGTTCTAGTTTTACCGGTACCGGCACCTGCAACGACAAAAAG
AGGGCCACTTATATGGGTGGCCGCCTTCTTTTGTTGTGGGTTTAATTGTTCTAACCAATT
AGTCATCTTCAT

>protein sequence
MKMTNWLEQLNPQQKKAATHISGPLFVVAGAGTGKTRTLTTRIAYLIEELGVAPDSILAV
TFTNKAAREMKERIVEMAGPYATNTWIYTFHAFGVKVLRRDIEHLKMGYTVNFNIIDEDD
AKAMVRKIIKDLNLDTKSYKANAIRHKISLFKHLNIDYFDNANERLVLEKYTHELITNNL
LDFDDLQILTYKLFDEHQHILEYYQNKFNFILVDEFQDTDHLQYKMMKLLAGKQKNLFVV
GDPDQSIYAFRGANYDNAKFFLNDFKNEDGSKAEIVLDLNYRSTKEILKFANKLITSNKN
RPFSKSLETDLGNGLKPFIWSAQSDLNEAQMIANEIETLIKDGGYKYSDIAILYRNNALS
RSFEDVFMKYNIPYVLYGGISFYQRKEIKDILAYIRLVVDPNLDFYLMRIINTPRRAIGP
TTLNKLQSYAKEHNMSMFDAIDSFDISGKTKQSLLEFKTLILEMKFDFQNFTELGKVVDY
VAYKTGYNQMLETDKDEYSEERIEYIKELKNPFVQAEAYYEGTFLEKLMQLLDQIALYSD
LDRNKVSDAVVLSTFHQVKGLEFKVVFMTVMEEQIFPSSQSFMDLNELEEERRIAYVGVT
RAKERLYLTRSEKRLLYGALIYPRPSRFLKEMMPEQEVFTKKGNYTPQQSTSSNYLKPGD
SVTHQVFGKGIVVSVDKDIATIAFSMPHGIKQLLESHPSIKKNW