ACL_RS06720

Uniprot: A9NHX0
Description: glucose-6-phosphate isomerase
EC number: 5.3.1.9
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6-phosphate. {ECO:0000255|HAMAP-Rule:MF_00473}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|HAMAP-Rule:MF_00473}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. {ECO:0000255|HAMAP-Rule:MF_00473}.
Active site: ACT_SITE 279 279 Proton donor. {ECO:0000255|HAMAP-Rule:MF_00473}.; ACT_SITE 300 300 {ECO:0000255|HAMAP-Rule:MF_00473}.; ACT_SITE 413 413 {ECO:0000255|HAMAP-Rule:MF_00473}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): pgi
Gene names (synonym):
Mass: 47,924
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; glucose-6-phosphate isomerase activity [GO:0004347]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]
Gene ontology IDs: GO:0004347; GO:0005737; GO:0006094; GO:0006096
Chain: CHAIN 1 423 Glucose-6-phosphate isomerase. /FTId=PRO_1000081229.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the GPI family. {ECO:0000255|HAMAP-Rule:MF_00473}.
Protein families: GPI family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHX0
MEROPS:
EnsemblBacteria KO: ABX81950
UniPathway: K01810
CDD:
Gene3D:
HAMAP:
InterPro: MF_00473
PANTHER: IPR001672;IPR018189
PIRSF: PTHR11469
PRINTS:
PROSITE: PR00662
Pfam: PS00765;PS00174;PS51463
ProDom: PF00342
SMART:
SUPFAM:
TIGRFAMs:

1423471-1424743(-)

>nucleotide sequence
TCATTTTTTCCCTAATAATCTAAACATATTTTTCTTGTAAGCTTCAACACCTGGTTGGTC
AAATGGGTTTACCTCTAAAAGGTAAGCACTCATAGCACATGCAATTTCAAAGAAATATAC
TAAATAACCAAAGTGATATGCATCCATTTTATCGATCGTGATAACAATATTTGGTACGCC
GCCATCAATATGAGCTTCCTTAGTACCTAAGAATGCTTGTTCATTCACATAAGATATTTC
TTTTCCAGCAATGTAATTTAATTTATCTAAATCTTCTTCTACAAAAGGAATAGATAGTTT
ATCTGTCTTTTTAACATTTAAAACTGTTTCAAAAATGATACGATTACCATCTTGAATTTG
TTGACCTAAAGAGTGTAGGTCTGTAGTAAAGGATGCAGAGTGTACTAATAAACCTTTTCC
ACCTTTACCTTCGGATTCACCAAATAATTGTTTCCACCATTCAGCAAAAAATGCTAAACG
TGGTTCATAGTTAATTAAATACTCCACATCTTTACCAGATTGATTTAATAAAAATCTAGT
CACTGCATAAAGATATGCTTTGTTTTTCTTTAAACTTGGATCTTGAGCATCATGATATGC
ATCCTGTGCACCCTTGATCATTTTTTCAACATCTATACCTACAAAAACAAAAGGTAGTAA
ACCAACAGCGGATAATACAGAAAAACGTCCACCCACATTATCTTCAATCACAAATCTTTC
ATAACCCTCATTGATTGCTAATTGGTATAAAGAACCACGTGCCTTATCTGTTGTTGCAAA
AATTCTTTTTCTAGCTTCTTTGACACCATATTTATTTTCAATATGTGCCTTTAGTAATCT
AAATGCTACTGCTGGTTCTGTTGTTGTACCTGATTTTGAAATCACGTTAATGACATAGTT
TTTCTTGTTTAAGTATTTAAGTAAATGTTTTAAGTAATTTGCAGATAAATGATGTCCTGC
AAAAATGAGTTCTGGTTTTTGTTTTTTAAATGGTGTCTTTAAAAATTCATATCCAGCTTT
AGCGCCTAAATAAGAACCACCAATCCCAATAACAACAATCGCGTCAACATTTTTATGTTG
TTCTTTTAACTTATAAATACGATCTAATTCTTCTTTATCATACGTTAAAGGTAAATCTAA
CCATCCTAAAAAATCATTACCTAACCCAGACTTATTTTGAATGACATCATGTAATTCATT
CACTTGATCTTGTAAACTAAAAACATTCGTTTTAAGAAATTTCTTAGCATCTTTTATATC
TAATTTAATCAT

>protein sequence
MIKLDIKDAKKFLKTNVFSLQDQVNELHDVIQNKSGLGNDFLGWLDLPLTYDKEELDRIY
KLKEQHKNVDAIVVIGIGGSYLGAKAGYEFLKTPFKKQKPELIFAGHHLSANYLKHLLKY
LNKKNYVINVISKSGTTTEPAVAFRLLKAHIENKYGVKEARKRIFATTDKARGSLYQLAI
NEGYERFVIEDNVGGRFSVLSAVGLLPFVFVGIDVEKMIKGAQDAYHDAQDPSLKKNKAY
LYAVTRFLLNQSGKDVEYLINYEPRLAFFAEWWKQLFGESEGKGGKGLLVHSASFTTDLH
SLGQQIQDGNRIIFETVLNVKKTDKLSIPFVEEDLDKLNYIAGKEISYVNEQAFLGTKEA
HIDGGVPNIVITIDKMDAYHFGYLVYFFEIACAMSAYLLEVNPFDQPGVEAYKKNMFRLL
GKKW