ACL_RS06855

Uniprot: A9NE17
Description: ATP-dependent zinc metalloprotease FtsH
EC number: 3.4.24.-
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor: COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_01458}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01458}
Enzyme regulation:
Function [CC]: FUNCTION: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP-Rule:MF_01458}.
Pathway:
Active site: ACT_SITE 445 445 {ECO:0000255|HAMAP-Rule:MF_01458}.
Binding site:
Calcium binding:
DNA binding:
Metal binding: METAL 444 444 Zinc; catalytic. {ECO:0000255|HAMAP-Rule:MF_01458}.; METAL 448 448 Zinc; catalytic. {ECO:0000255|HAMAP-Rule:MF_01458}.; METAL 520 520 Zinc; catalytic. {ECO:0000255|HAMAP-Rule:MF_01458}.
Nucleotide binding: NP_BIND 222 229 ATP. {ECO:0000255|HAMAP-Rule:MF_01458}.
Site:
Gene names (primary): ftsH
Gene names (synonym):
Mass: 70,955
Subunit structure [CC]: SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_01458}.
Gene ontology (GO): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; protein catabolic process [GO:0030163]
Gene ontology IDs: GO:0004222; GO:0005524; GO:0005886; GO:0008270; GO:0016021; GO:0016887; GO:0030163
Chain: CHAIN 1 641 ATP-dependent zinc metalloprotease FtsH. /FTId=PRO_0000400318.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: In the central section; belongs to the AAA ATPase family. {ECO:0000255|HAMAP-Rule:MF_01458}.; SIMILARITY: In the C-terminal section; belongs to the peptidase M41 family. {ECO:0000255|HAMAP-Rule:MF_01458}.
Protein families: AAA ATPase family; Peptidase M41 family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NE17
MEROPS: M41.009
EnsemblBacteria KO: ABX81977
UniPathway: K03798
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_01458
PANTHER: IPR003593;IPR003959;IPR003960;IPR005936;IPR027417;IPR000642
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00674
ProDom: PF00004;PF01434
SMART:
SUPFAM: SM00382
TIGRFAMs: SSF52540

1447180-1449106(+)

>nucleotide sequence
ATGAATAAACAACAAAAACCTAAAAGAAGCCCGCTTCGTCCGGACTATCTTGTAATTGTA
ATTATTATACTTTTAGCAATTGGTATGTACTTCTTCTTTACAGAGATGATGGCACCAAAA
GTTAAACAGTTTGACGAATTTGAATTTATAGCAGCAATCGAATCAGGACAGATTGCAACT
GTACGAAGTGAATATGTCGGTGGAGATAACTTTAACCTATGGGAAGTTACCGGTACATTT
ACAACAGGTAACGCTCCAGAAGGTGTCGGAAGTTATGTCATTATACTTTATGGTGATAGG
TTAAACAACATCCAAGACATCATCATTACTTATAATGAGTTAAACCCAAGTACACCAATC
ACAGTATCATTTGTTCCACACGTAAGTGTTGATTTCTGGAATATTATCTCAACCCTTCTC
TTGATTGCAGCACCTATTGTTTTAGTCGTTATTATGTTTAGATCGATGAGTTCTCAATCT
AATAAAGCTCAAGATTTTACAAAAAACCGTGCCAAATTATCTCAAGGTAGAAAAGTTAAG
TTTTCTGACATTGCTGGTGCTGATGAAGAAAAAGCTGAAATGGCTGAATTAATCGACTTC
TTAAAAAATCCTAAGAAATATGCTGATATGGGTGCTCGTGTACCAAAGGGTGTCTTATTA
GTAGGTCAACCTGGTACAGGTAAAACCTTATTAGCTAAAGCAGTTGCTGGTGAAGCACAA
GTACCATTCTTCTCAATTTCAGGTTCTGATTTCGTTGAACTTTATGTTGGGGTTGGTGCA
AGCCGTGTTAGAGATTTATTTAAAGTTGCAAAACAAAGTGCACCTTGTATTATATTTATT
GATGAAATCGATGCTGTAGGTCGCCAACGTGGTGCTGGTATGGGTGGCGGAAATGATGAA
AGAGAACAAACATTAAACCAACTACTTGTTGAAATGGATGGTTTTAGTGCAAACTTAGGT
ATCATCATTATGGCTGCAACAAACAGACCAGACGTATTAGACCCTGCATTATTAAGACCA
GGCCGTTTTGATAGACAAATTACAATGCAAGTACCTGATCAAAAATCACGTGAAGAAATC
TTAAAAGTTCATGCACGTAGTAAAAAATTAGATCCTACGATTAAATTTAGTGAAGTTGCA
ATGCGTATCCCAGGATTTACTGGTGCTGATATTGAAAACTTACTAAACGAAGCAGCATTA
TTAGCAGCAAGAGAATCTAGAACAGTCATTTCAATGCAAGACATTGATGAGGCAGCTGAC
CGTGTAACTATGGGACCTGCTAAGAAATCTAGAAAATACTCACCAAATGAAAAGAAAATG
GTTGCCTACCATGAAGCCGGTCATGCGGTTATTGGATTAAAGGTTAACTTAGCTTCTACT
GTTCAAAAAGTAACAATTGTCCCACGAGGACGTGCTGGTGGTTATGCACTTTATACACCA
GTTGAAGAAAAATTCAACTATGCTAAAAGTGAGTTACTAGCAATGATTACTTCTGCCTTA
GGTGGACGTGTTGCTGAAGAAATTATGTTTGATGATGTTACAACCGGAGCATATGATGAC
TTTAAACGTGCAACCAAGTTAGCACGTAGTATGGTTACAGAATACGGTATGTCTGATCTT
GGACCTATCCAATATGAATCAGATAGTGGAAACGTCTTCTTAGGTAGAGATTACTTAAAA
GATAAAAACTTCTCTGATGCAGTTGCACTTGAAATCGATAGAGAAGTTCGTGCAATTATT
ACTGAGTGTTACGAACATGCTAGAAAAGTCATTAATGAAAATAAAAATTTACTAGATAAT
ATCGCTAAATACTTAATCGCTGTAGAAACACTTACTAAAACTGATATTGATGAAATAGCA
GCTACTGGACAACTTCAATGGTGGGATAACCGTGAAGTTGAAGAAGATTCTAAGAAAAGC
GAATAA

>protein sequence
MNKQQKPKRSPLRPDYLVIVIIILLAIGMYFFFTEMMAPKVKQFDEFEFIAAIESGQIAT
VRSEYVGGDNFNLWEVTGTFTTGNAPEGVGSYVIILYGDRLNNIQDIIITYNELNPSTPI
TVSFVPHVSVDFWNIISTLLLIAAPIVLVVIMFRSMSSQSNKAQDFTKNRAKLSQGRKVK
FSDIAGADEEKAEMAELIDFLKNPKKYADMGARVPKGVLLVGQPGTGKTLLAKAVAGEAQ
VPFFSISGSDFVELYVGVGASRVRDLFKVAKQSAPCIIFIDEIDAVGRQRGAGMGGGNDE
REQTLNQLLVEMDGFSANLGIIIMAATNRPDVLDPALLRPGRFDRQITMQVPDQKSREEI
LKVHARSKKLDPTIKFSEVAMRIPGFTGADIENLLNEAALLAARESRTVISMQDIDEAAD
RVTMGPAKKSRKYSPNEKKMVAYHEAGHAVIGLKVNLASTVQKVTIVPRGRAGGYALYTP
VEEKFNYAKSELLAMITSALGGRVAEEIMFDDVTTGAYDDFKRATKLARSMVTEYGMSDL
GPIQYESDSGNVFLGRDYLKDKNFSDAVALEIDREVRAIITECYEHARKVINENKNLLDN
IAKYLIAVETLTKTDIDEIAATGQLQWWDNREVEEDSKKSE